Navigation Links
Beyond the little blue pill: scientists develop compound that may treat priapism

Bethesda, MD -- It's not the little blue pill famous for helping men get big results, but for those who need it, the outcome might be even more significant. A new research report published online in The FASEB Journal, offers hope to men who experience priapism. This condition, which is often seen in men with sickle cell disease, causes erections lasting so long that they cause permanent damage to the penis. Specifically, a compound, called "C6'" offered mice -- with and without sickle cell disease -- relief by normalizing nitric oxide levels in penile blood. In addition to helping men with priapism, this action of this compound also provides insight for future research related to vascular and circulatory disorders such as hypertension.

"This study has implications for quality of life by suggesting the possible role of a drug therapy for controlled, physiologic release of nitric oxide that may treat conditions of altered nitric oxide signaling or function," said Gwen Lagoda, M.S., a researcher involved in the work from the Department of Urology at Johns Hopkins Medical Institutions, in Baltimore, Maryland. "Its application may extend beyond erection disorders and include other health conditions involving abnormal circulation and blood flow."

Scientists analyzed two groups of experimental mice. The first group had both endothelial and neuronal nitric oxide synthase knocked out. The second group of mice had sickle cell disease. In both groups of mice, nitric oxide signaling was known to be abnormal and resulted in abnormal erections. When these mice were given C6' treatment, their molecular abnormalities were reduced and erectile functioning returned to levels similar to normal mice.

"Thanks to massive advertising, when people think of 'E.D.,' they often think of an inability to achieve or maintain an erection," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "What they don't realize is that there can be other problems as well. Priapism is a dangerous and painful form of erectile dysfunction that is overlooked. Hopefully this compound will be just as effective in people as it was in mice."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Beyond the microscope: Identifying specific cancers using molecular analysis
2. Beyond base pairs: Mapping the functional genome
3. Beyond the Genome
4. Greater effort needed to move local, fresh foods beyond privileged consumers
5. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
6. FASEB SRC announces conference: Renal Hemodynamics: Integrating with the Nephron & Beyond
7. Variations of a single gene can lead to too much or too little growth, study shows
8. Chemical fingerprinting tracks the travels of little brown bats
9. NTU researchers study little mighty creature for scientific breakthrough
10. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
11. Cell therapy a little more concrete thanks to VIB research
Post Your Comments:
(Date:11/17/2015)... 17, 2015 Paris from ... --> Paris from 17 th until ... biometrics innovation leader, has invented the first combined scanner in ... same scanning surface. Until now two different scanners were required: ... can capture both on the same surface. This innovation ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
(Date:11/10/2015)... , Nov. 10, 2015 ... behavioral biometrics that helps to identify and verify ... Signature is considered as the secure and accurate ... identification of a particular individual because each individual,s ... accurate results especially when dynamic signature of an ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... November 30, 2015 , ... Global Stem Cells Group ... of a new closed system for isolating adipose-derived stem cells. The announcement starts a ... of adipose tissue. SVF is a component of the lipoaspirate obtained from liposuction of ...
(Date:11/30/2015)... Partnership includes an MPP ... u niversity , s Solid Drug Nanoparticle (SDN) Technology ... - up through cost cuts of ... where licensees based anywhere in the world will have the right to make, use ... , where licensees based anywhere in the world will have the right to ...
(Date:11/30/2015)... Atlanta, GA (PRWEB) , ... November 30, 2015 ... ... announced a new globally touring exhibition Jurassic World: The Exhibition, opening in March ... Exhibition will embark on a worldwide tour including several North American tour dates. ...
(Date:11/30/2015)... Colo. , Nov. 30, 2015  Aytu BioScience, ... on urological and related conditions, will present at two ... at, an interactive real-time virtual conference, to be ... Event Investor Conference, to be held December 2 nd ... Los Angeles and streamed live via webcast. ...
Breaking Biology Technology: