Navigation Links
Beyond the little blue pill: scientists develop compound that may treat priapism
Date:9/30/2013

Bethesda, MD -- It's not the little blue pill famous for helping men get big results, but for those who need it, the outcome might be even more significant. A new research report published online in The FASEB Journal, offers hope to men who experience priapism. This condition, which is often seen in men with sickle cell disease, causes erections lasting so long that they cause permanent damage to the penis. Specifically, a compound, called "C6'" offered mice -- with and without sickle cell disease -- relief by normalizing nitric oxide levels in penile blood. In addition to helping men with priapism, this action of this compound also provides insight for future research related to vascular and circulatory disorders such as hypertension.

"This study has implications for quality of life by suggesting the possible role of a drug therapy for controlled, physiologic release of nitric oxide that may treat conditions of altered nitric oxide signaling or function," said Gwen Lagoda, M.S., a researcher involved in the work from the Department of Urology at Johns Hopkins Medical Institutions, in Baltimore, Maryland. "Its application may extend beyond erection disorders and include other health conditions involving abnormal circulation and blood flow."

Scientists analyzed two groups of experimental mice. The first group had both endothelial and neuronal nitric oxide synthase knocked out. The second group of mice had sickle cell disease. In both groups of mice, nitric oxide signaling was known to be abnormal and resulted in abnormal erections. When these mice were given C6' treatment, their molecular abnormalities were reduced and erectile functioning returned to levels similar to normal mice.

"Thanks to massive advertising, when people think of 'E.D.,' they often think of an inability to achieve or maintain an erection," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "What they don't realize is that there can be other problems as well. Priapism is a dangerous and painful form of erectile dysfunction that is overlooked. Hopefully this compound will be just as effective in people as it was in mice."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Beyond the microscope: Identifying specific cancers using molecular analysis
2. Beyond base pairs: Mapping the functional genome
3. Beyond the Genome
4. Greater effort needed to move local, fresh foods beyond privileged consumers
5. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
6. FASEB SRC announces conference: Renal Hemodynamics: Integrating with the Nephron & Beyond
7. Variations of a single gene can lead to too much or too little growth, study shows
8. Chemical fingerprinting tracks the travels of little brown bats
9. NTU researchers study little mighty creature for scientific breakthrough
10. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
11. Cell therapy a little more concrete thanks to VIB research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the world-leading ... and publication industries, will provide the data management solution ... (NPSC). ... Phenotypic analysis measures the ... organisms, allowing comparisons between states such as health and ...
(Date:1/21/2016)... --> ... report "Emotion Detection and Recognition Market by Technology (Bio-Sensors, NLP, ... Voice Recognition and Others), Services, Application Areas, End ... published by MarketsandMarkets, the global Emotion Detection and ... Billion by 2020, at a CAGR of 31.9%, ...
(Date:1/20/2016)... SAN JOSE, Calif. , Jan. 20, 2016 ... leading developer of human interface solutions, today announced ... touch controller solution for wearables and small screen ... appliances such as printers. Supporting round and rectangular ... the S1423 offers excellent performance with moisture on ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... 2016  Matchbook, Inc., a company specializing in ... companies, announced today the appointment of Jim ... brings nearly 25 years of experience in supply ... nearly two decades in executive level roles as ... Genzyme and, most recently headed global logistics and ...
(Date:2/10/2016)... ... February 10, 2016 , ... LATHAM, NEW YORK... ... SPIE Photonics West conference in San Francisco’s Moscone Center from February 16-18, ... same venue. , These latest InGaAs PIN diode standard packages feature a TO-46 ...
(Date:2/10/2016)... Boston, MA (PRWEB) , ... February 10, 2016 ... ... system is now available on Microsoft Azure. On Azure, Arvados provides capabilities for ... “We saw clear demand for Microsoft Azure from major institutions collecting and analyzing ...
(Date:2/10/2016)... ... February 09, 2016 , ... Creation Technologies, leading global ... Highest Overall Customer Rating Award from Circuits Assembly , today announced its milestone ... USA, Canada, Mexico and China. , The EMS provider, known in the EMS ...
Breaking Biology Technology: