Navigation Links
Beyond the little blue pill: scientists develop compound that may treat priapism
Date:9/30/2013

Bethesda, MD -- It's not the little blue pill famous for helping men get big results, but for those who need it, the outcome might be even more significant. A new research report published online in The FASEB Journal, offers hope to men who experience priapism. This condition, which is often seen in men with sickle cell disease, causes erections lasting so long that they cause permanent damage to the penis. Specifically, a compound, called "C6'" offered mice -- with and without sickle cell disease -- relief by normalizing nitric oxide levels in penile blood. In addition to helping men with priapism, this action of this compound also provides insight for future research related to vascular and circulatory disorders such as hypertension.

"This study has implications for quality of life by suggesting the possible role of a drug therapy for controlled, physiologic release of nitric oxide that may treat conditions of altered nitric oxide signaling or function," said Gwen Lagoda, M.S., a researcher involved in the work from the Department of Urology at Johns Hopkins Medical Institutions, in Baltimore, Maryland. "Its application may extend beyond erection disorders and include other health conditions involving abnormal circulation and blood flow."

Scientists analyzed two groups of experimental mice. The first group had both endothelial and neuronal nitric oxide synthase knocked out. The second group of mice had sickle cell disease. In both groups of mice, nitric oxide signaling was known to be abnormal and resulted in abnormal erections. When these mice were given C6' treatment, their molecular abnormalities were reduced and erectile functioning returned to levels similar to normal mice.

"Thanks to massive advertising, when people think of 'E.D.,' they often think of an inability to achieve or maintain an erection," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "What they don't realize is that there can be other problems as well. Priapism is a dangerous and painful form of erectile dysfunction that is overlooked. Hopefully this compound will be just as effective in people as it was in mice."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Beyond the microscope: Identifying specific cancers using molecular analysis
2. Beyond base pairs: Mapping the functional genome
3. Beyond the Genome
4. Greater effort needed to move local, fresh foods beyond privileged consumers
5. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
6. FASEB SRC announces conference: Renal Hemodynamics: Integrating with the Nephron & Beyond
7. Variations of a single gene can lead to too much or too little growth, study shows
8. Chemical fingerprinting tracks the travels of little brown bats
9. NTU researchers study little mighty creature for scientific breakthrough
10. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
11. Cell therapy a little more concrete thanks to VIB research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... , ... May 16, 2017 ... ... the general availability of its new ProxiMeta™ Hi-C metagenomic deconvolution service. ProxiMeta ... affordably—without culturing or high-molecular-weight DNA extraction—speeding research insights at lower cost. , ...
(Date:5/16/2017)... 16, 2017 Telehealth has long been ... something that has been kept completely separate from ... according to   Logicalis Healthcare Solutions , the ... solutions and managed services provider ( www.us.logicalis.com ), ... – interrelationship between telehealth, imaging, and EHR optimization ...
(Date:5/15/2017)... PA (PRWEB) , ... May 15, 2017 , ... ... insights in a presentation of “The Key Role of Specifications in Process Validation,” at ... of Philadelphia . The event will bring together leaders from the pharmaceutical and biotech ...
(Date:5/15/2017)... ... May 15, 2017 , ... Continuing to ... skincare brand has today launched its first-ever cross-medium campaign, #StandFirm, with high-visibility social ... digital and social media channels, emphasizing Algenist’s stance on individuality and disruption: ...
Breaking Biology Technology: