Navigation Links
Between B cells and T cells
Date:7/23/2013

dent and first author of the study. The researchers did indeed find immune cells, but the B cells had forgotten their previous identity. In their place were T cells and natural killer cells, which normally would not be found in these animals.

To find out whether the T and natural killer cells actually had come from the transplanted B cells, the researchers looked for the specific genetic footprint of B cells. Unlike most other cells in the body, B cells change their DNA sequence during their development. To produce antibodies, they bring together several gene segments by cutting and joining their DNA to create a sequence able to code for a functional antibody. The researchers found precisely this typical genetic footprint of B cells in both T cells and natural killer cells. They concluded that after the transcription factor EBF1 had been switched off, the transplanted B cells had forgotten their specialization and had turned into alternate cell types. Until now, it was only known that the absence of the transcription factor Pax5 had such an effect. "We believe that the two proteins regulate different aspects of cell type specification. EBF1 primarily represses genes that would initiate an alternative program of development in the B cells, while Pax5 ensures that they no longer react to signals that would enable them to select a different specialization," says Grosschedl.

The Freiburg-based researchers now want to understand the exact molecular interactions in the cells and better define the network of factors involved. In the long term, they hope this knowledge will allow cells to be reprogrammed, for example in the case of a pathological loss of a cell type.


'/>"/>

Contact: Dr. Rudolf Grosschedl
grosschedl@immunbio.mpg.de
49-761-510-8711
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
2. Drawing connections between food webs
3. Geographic information systems demonstrate links between health and location
4. Biosignatures distinguish between tuberculosis and sarcoidosis
5. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
6. Link between vitamin C and twins can increase seed production in crops
7. Study provides first evidence of coevolution between invasive, native species
8. How sweet it is: Tomato researchers discover link between ripening, color and taste
9. Highlighting molecular clues to the link between childhood maltreatment and later suicide
10. Differences between human twins at birth highlight importance of intrauterine environment
11. Caltech researchers find evidence of link between immune irregularities and autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... India , August 26, 2015 ... Three, Four, and Five Factor), Application (Travel & Immigration, ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... Billion by 2020, growing at a CAGR of 17.7% ... Tables and 82 F igures spread through 169 ...
(Date:8/24/2015)...  Based on its recent analysis of the biometric products ... Biometrics Company of the Year Award. DERMALOG is the leading ... Africa . It has particularly gained prominence ... one of the largest biometric mass applications in the world, ... Bank of Nigeria with its biometric ...
(Date:8/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... Alliance and the EMV Migration Forum.  ... Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. direct ... promoting adoption of smart card technology. To ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4
... The National Science Foundation (NSF) has awarded a three-year ... processes used to make custom DNA molecules with the ... led by Jean Peccoud, Associate Professor at the Virginia ... Associate Professors in the Grado Department of Industrial and ...
... path of destruction, an international research team has created ... protein nanocrystals. Using the Linac Coherence Light Source (LCLS), ... Laboratory in Menlo Park, Calif., the scientists fired femtosecond ... a stream of tumbling molecules, obliterating them as they ...
... OH. July 26, 2012 Congenital hypothyroidism is thyroid ... lead to neurocognitive impairments in infants and children. ... iodine daily during pregnancy for normal fetal thyroid hormone ... considers 1,100 g to be the safe upper limit ...
Cached Biology News:National Science Foundation awards $1 million to improve the efficiency of DNA fabrication 2Speed and power of X-ray laser helps unlock molecular mysteries 2New study associates excess maternal iodine supplementation with congenital hypothyroidism 2
(Date:9/2/2015)... , Sep. 02, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... to their offering. This report follows ... characteristic that can be objectively measured and evaluated ... processes as well as pharmacological responses to a ...
(Date:9/2/2015)... 2015 Research ... the addition of Jain PharmaBiotech,s new report ... to their offering. The ... fluorescence in situ hybridization (FISH), comparative genomic ... includes application of nanobiotechnology, microarrays, real-time polymerase ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... of botanical and plant-derived compounds. BCC Research reveals in its new report ... because this market defines the category and generates the most market demand. ...
(Date:9/2/2015)... Australian prostate cancer technology company Minomic International Ltd has ... science that uses its patented antibody. The ... cancer diagnostic test known as MiCheck® next year, was ... peer-reviewed Australian Museum Eureka Science Prize for Excellence ... is awarded for ground breaking research that has only ...
Breaking Biology Technology:Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3
... N.Y., April 6, 2011 Health Care Compliance ... Health System of Detroit, MI., has selected the ... with the conflict of interest disclosure process. COI-SMART ... than 20,000 employees. (Logo: http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO) ...
... Fla., April 5, 2011 Embryo Donation International ... donation facilities in the United States, officially opened today ... the globe desiring to build a family.     ... dedicated mission is to reduce the number of ...
... BALTIMORE, April 5, 2011 Champions Oncology, Inc. (OTC: CSBR) ... it has completed the private placement of 12.5 million shares ... share, resulting in gross proceeds to the company of $9.4 ... used to invest in: Sales resources dedicated ...
Cached Biology Technology:Conflict of Interest Management System Selected by Henry Ford Health System 2A New Company Is Born - Embryo Donation International 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 3
... APAgene kits are designed to rapidly and ... our patented APA Technology. APAgene provides hassle-free, ... price. All necessary ingredients are provided in ... be used for gap filling, localized cloning ...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
... is designed to deparaffinize and perform Heat ... paraffin-embedded tissue sections mounted on glass microscope ... paraffin at the high temperature used in ... of the paraffin by detergent. Formaldehyde fixation ...
... to deparaffinize and perform Heat Induced Antigen ... sections mounted on glass microscope slides. Deparffinization ... the high temperature used in HIER (over ... paraffin by detergent. Formaldehyde fixation impairs or ...
Biology Products: