Navigation Links
Between B cells and T cells
Date:7/23/2013

Mature cells develop through a number of immature stages. During this process, they must remember the specialization they are committed to. For immune system B cells, Rudolf Grosschedl of the Max Planck Institute of Immunobiology and Epigenetics and his team have discovered that the transcription factor EBF1 is crucial for B cells to remember who they are. When the researchers switched off the transcription factor, the cells lost their previous identity and developed into T cells. Unlike most other cell types, B cells have a characteristic footprint in their genetic makeup and this allowed the researchers to identify the origin of each individual cell.

During the transition from stem cells to becoming a functional part of the immune system, cells must undergo a number of specialization stages where they have the opportunity to decide between pathways leading to the various cell types found in the blood. It is also important that once they have chosen a specialization, they remain committed to it.

Immune system B and T cells come from the same stem cell. Rudolf Grosschedl and his colleagues were able to prove as early as 1995 that the transcription factor EBF1 is active only in some of these cells and this induces their development into B cells. Until now, however, it was unclear whether EBF1 also played a part in constantly reminding the B cells of their identity.

B cells usually die when EBF1 is switched off. In collaboration with researchers from the University of Freiburg, the Max Planck researchers collected mouse B cells at a late stage of their development and transferred them to mice lacking an immune system. They then switched off the EBF1 gene in the transplanted B cells. After three months, they checked whether immune cells were still present in the mice. "We thought that the chance of this transfer enabling the cells to remain alive was slim, so we were very pleased that it worked," says Robert Nechanitzky, a doctoral stu
'/>"/>

Contact: Dr. Rudolf Grosschedl
grosschedl@immunbio.mpg.de
49-761-510-8711
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
2. Drawing connections between food webs
3. Geographic information systems demonstrate links between health and location
4. Biosignatures distinguish between tuberculosis and sarcoidosis
5. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
6. Link between vitamin C and twins can increase seed production in crops
7. Study provides first evidence of coevolution between invasive, native species
8. How sweet it is: Tomato researchers discover link between ripening, color and taste
9. Highlighting molecular clues to the link between childhood maltreatment and later suicide
10. Differences between human twins at birth highlight importance of intrauterine environment
11. Caltech researchers find evidence of link between immune irregularities and autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014---A team of researchers from The Chinese University of ... gene of wild soybean linked to salt tolerance, with ... saline soil. This study published online in Nature ... genomic information for crop improvement. , Soybean is an ... human selection, cultivated soybeans have less genetic diversities than ...
(Date:7/11/2014)... animals often develop relationships with other group members to ... wild chacma baboons the strategy for grooming activities shows ... just published in the scientific journal Biology Letters ... baboons is not practiced without ulterior motives. To be ... the individual, while grooming another individual can provide access ...
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... at the Stanford University School of Medicine have taken ... cells that could eventually be transplanted into living organisms. ... surgical resident Oscar Abilez, MD, and colleagues have successfully ... building blocks of blood vessels, after placing them in ...
... over a decade, the technique of distraction has been ... to reduce pain associated with certain medical procedures. The ... there is an important psychological element in the perception ... the harmful stimulus affecting the perception of the pain. ...
... of York have made a huge leap forward in the ... the Department of Biology has made a significant advance in ... biological warfare. , Bacteria like E. coli frequently try to ... called colicins, which are potent toxins. , The research ...
Cached Biology News:Stanford doctors advance in bid to turn mice stem cells into blood vessels 2Stanford doctors advance in bid to turn mice stem cells into blood vessels 3Virtual realities against pain 2
(Date:7/10/2014)... Deep Knowledge Ventures last week ... ‘Commercialising Longevity Research’ and welcomed a host of ... Bioscience Innovation Center for the event, organised by ... Ltd. The meeting highlighted the need for both ... age-related disease, as well as the crucial role ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... July 10, 2014 On July ... Medvedev , presented Russia,s first ... . The Company is developing a unique project called ... BIOCAD develops a number of innovative drugs based on ... The ceremony took place at the International Exhibition "Innoprom ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... , , ... issue of the journal,Diabetic Hypoglycemia ( http://www.hypodiab.com ) reviews ... Professor Vincent Marks , a leading ... criminal behavior, discusses how,hypoglycemia-related neuroglycopenia can cause behavioral changes, which ...
... ... the company as a regulatory consultant after retiring from Eli Lilly & Co. ... science and human pharmaceutical products, including director of regulatory affairs and clinical research. ... US regulatory submissions. , ...
... ... ... 2010 -- Agriculture is a game-changer that addresses multiple global issues – hunger, poverty, ... CEO Ellen Kullman told attendees of the 40th World Economic Forum Annual ...
Cached Biology Technology:Hypoglycemia - A Role in Criminal Behavior and a Consideration for Custodial Care 2Hypoglycemia - A Role in Criminal Behavior and a Consideration for Custodial Care 3Michael Langley, DVM, MBA, RAC Joins the Anson Group as a Regulatory Consultant 2DuPont Chair and CEO: Agriculture is Key to Global Economic Growth, Sustainability and Security 2