Navigation Links
Better ways to predict kidney disease risk for African Americans
Date:10/13/2011

occurs," said Dr. Thadani. These results suggest that patients with two variants may benefit from early therapies to protect their kidneys.

John Sedor, MD (Case Western Reserve University) and his collaborators examined individuals' kidney tissues and found that the protein created by the APOL1 gene resides in different regions of the kidney in patients with FSGS or HIVAN compared to individuals without kidney disease. "Its appearance in the walls of small arteries in the kidney that occurs only in disease suggests that blood vessels may have an underappreciated role in the development and progression of these diseases," said Dr. Sedor.

People inherit two copies of the APOL1 gene -- one from each parent. If they inherit only one copy with a variant, they are resistant to infections caused by a parasite endemic to Africa. For this reason, the variants are common in individuals with African ancestry. Unfortunately, if both copies of the APOL1 gene contain a variant, an individual has an increased risk of kidney failure.

The studies' results provide new information about kidney disease and point to the dangers that African Americans with APOL1 gene variants may face if steps are not taken to protect their kidneys. Early screening and treatment could potentially safeguard against kidney failure and early death for millions of individuals.


'/>"/>
Contact: Adrienne Lea
alea@asn-online.org
American Society of Nephrology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. National labs leading charge on building better batteries
2. Better planning required if EU is to meet energy targets
3. Location matters: For invasive aquatic species, its better to start upstream
4. Texas AgriLife Research scientists making better melons
5. Medical homes linked to better health, school performance
6. New cellular surprise may help scientists better understand human mitochondrial diseases
7. International pharmacogenomics conference to focus on better drug treatment based on genetics
8. Dual-action protein developed at Stanford better restricts blood vessel formation
9. What parasites eat is the key to better drug design
10. U of M researchers use improved imaging technique; discover a better approach to diagnosing epilepsy
11. Cold electrons to aid better design of drugs and materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 8, 2014 Fingerprint Cards, ... design win (DW). An Asian OEM has selected FPC1021 for ... start in August 2014.   FPC is proud ... has a planned date for start of mass production in ... of SEK 5M, for delivery in the first half of ...
(Date:7/10/2014)... the large, mainly tropical flowering plant family Melastomataceae (Meadow Beauty ... rely on bees for their pollination. Only about 100 are ... flowers of Axinaea appear in clusters of few ... different species are pink, yellow, orange or red. The stamens ... of their bulbous appendages. The pollination mechanism of Axinaea ...
(Date:7/10/2014)... your popcorn or soap might not be ape friendly, and ... an analysis in the Cell Press journal Current Biology ... oil has already led to the conversion of Southeast Asian ... particular. If guidelines are not put in place very soon, ... Asia into Africa will be bad news for great apes ...
Breaking Biology News(10 mins):FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Novel type of bird pollination mechanism discovered in South America 2Hunger for vegetable oil means trouble for Africa's great apes 2
... than a dozen countries joined together to sequence the tomato ... The Tomato Genomics Consortium directed the research effort, which ... Foundation and the USDA,s Agriculture Research Services. The OU ... Emeritus in the College of Arts and Sciences, was one ...
... 2012) -- A detailed analysis of more than 4 ... help electricity producers slash as much as 30 percent ... dioxide from power plant emissions. The research by ... Lawrence Berkeley National Laboratory (LBNL) and the Electric Power ...
... Madrid, May, 31st, 2012.- Madrid will become ... during the Biomedical Innovation Conference 2012, focused on ... Madrid-MIT M+Vision Consortium. This new organization has been ... and the regional Government of the Comunidad de ...
Cached Biology News:New materials could slash energy costs for CO2 capture 2New materials could slash energy costs for CO2 capture 3MADRID-MIT M+Vision Consortium hosts Biomedical Innovation Conference 2012 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... According to the International Atomic Energy Agency (IAEA) ... terrorists acquiring sufficient quantities of plutonium or highly ... explosive device. The IAEA also notes that most ... quantities, which can be challenging to detect with ... study appearing this week in the Journal ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... ... ... , ... ...
... ... preemergence herbicide gives corn and soybean growers the opportunity to produce higher yields and ... plants have less pressure and improved yield potential. , ... Philadelphia, PA (PRWEB) March 9, 2010 -- As ...
... ... ... ... ...
Cached Biology Technology:Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 2Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 3Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 4Netsmart Technologies Selected by Douglas Gardens Community Mental Health to Provide Behavioral Health Software Solution 5Preemergence Herbicides from FMC Boost Early Season Plant Health in Corn and Soybeans and Help Optimize Yields for 2010 2Preemergence Herbicides from FMC Boost Early Season Plant Health in Corn and Soybeans and Help Optimize Yields for 2010 3SPO Medical Secures Agreement in Sleep Apnea Market 2SPO Medical Secures Agreement in Sleep Apnea Market 3SPO Medical Secures Agreement in Sleep Apnea Market 4SPO Medical Secures Agreement in Sleep Apnea Market 5SPO Medical Secures Agreement in Sleep Apnea Market 6
MOUSE ANTI RAT RT1Ac Immunogen: PHA activated rat lymphocytes...
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
Biology Products: