Navigation Links
Better ways to predict kidney disease risk for African Americans
Date:10/13/2011

may be used to determine people's risk for kidney failure," said Dr. Gharavi.

Jeffrey Kopp, MD (National Institutes of Health) and his team studied 271 African American cases of FSGS and HIVAN, 168 European American cases, and 939 healthy individuals. African Americans with variants in both copies of the APOL1 gene had a greatly increased risk of developing FSGS and HIVAN. Approximately 13% of African Americans (more than 3.5 million individuals) carry two APOL1 gene variants, and these individuals have a 4% risk during their lifetime of developing FSGS; those with untreated HIV have a 50% risk during their lifetime of developing HIVAN. "We also found that APOL1-associated FSGS tended to arise at an earlier age and to progress to kidney failure more rapidly than non-APOL1-associated FSGS," said Dr. Kopp.

Martin Pollak, MD (Beth Israel Deaconess Medical Center) and his group looked to see if APOL1 gene variants confer risks for other types of kidney disease among 2,867 African Americans. Nondiabetic individuals with two APOL1 gene variants had a four-fold increased risk of developing chronic kidney disease over nondiabetics without the gene variants. (No increased risk occurred among diabetics.) "Our research shows that APOL1 variants explain the difference between the high rate of kidney disease in African Americans compared with European Americans," said Dr. Pollak.

Dr. Pollak also collaborated with Ravi Thadani, MD (Massachusetts General Hospital) and others to examine whether African Americans with APOL1 gene variants need dialysis to treat kidney failure at a younger age than those without the variants. Among 407 African Americans with kidney failure, individuals with two gene variants started dialysis at an average age of 49.0 years, compared with 55.9 years for those with one gene variant and 61.8 years for those with no variants. "We may be able to predict when Blacks with kidney disease will experience kidney failure well before it
'/>"/>

Contact: Adrienne Lea
alea@asn-online.org
American Society of Nephrology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. National labs leading charge on building better batteries
2. Better planning required if EU is to meet energy targets
3. Location matters: For invasive aquatic species, its better to start upstream
4. Texas AgriLife Research scientists making better melons
5. Medical homes linked to better health, school performance
6. New cellular surprise may help scientists better understand human mitochondrial diseases
7. International pharmacogenomics conference to focus on better drug treatment based on genetics
8. Dual-action protein developed at Stanford better restricts blood vessel formation
9. What parasites eat is the key to better drug design
10. U of M researchers use improved imaging technique; discover a better approach to diagnosing epilepsy
11. Cold electrons to aid better design of drugs and materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... Sweden , April 2, 2015 ... its touch fingerprint sensor FPC1025 from the distributor World ... will commence during Q2 2015 although the major part ... The sensors will be used by smartphone manufacturers in ... 110 MSEK is included in the communicated revenue guidance ...
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
(Date:3/26/2015)... March 26, 2015 The Granite ... recreation and athletic club, today announced it has implemented ... freedom of movement for members and staff, while restricting ... comprehensive process, we selected FST,s IMID Access system because ... for our members and staff, in addition to unparalleled ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... Chicago, November 23, 2010 Results of the world,s first ... or PrEP, were released online in the New England ... iPrEx, indicated an estimated 43.8% reduction of new HIV infections ... HIV, compared to those who took a placebo pill. ...
... how biological clocks adjust to having less sunlight in the winter ... shift work. Scientists studying the daily activity cycle in plants ... process that enables the plant,s genes to respond to the times ... of daylight in between. This system helps the plant to ...
... better tool to study how cells adhere to each other. ... stick together. Different kinds of cells have different kinds of ... focus on tens of thousands of them at a time ... but not on a single molecule. Sivasankar, an Iowa State ...
Cached Biology News:AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 2AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 3AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 4Iowa State, Ames Lab researcher develops new way to study single biological molecules 2Iowa State, Ames Lab researcher develops new way to study single biological molecules 3
(Date:5/5/2015)... CA (PRWEB) May 05, 2015 Franz ... technology, today announced that its flagship product, AllegroGraph, has ... Graph Database Market Update report. AllegroGraph is ... leveraging the W3C industry standards. Graph databases are skyrocketing in ... years, according to a recent DBMS ranking by ...
(Date:5/5/2015)... , May 5, 2015 CytomX, a ... cancer, today announced that Sean McCarthy , D. ... Suisse Antibody Day in New York ... Dr. McCarthy will present an overview of CytomX,s Probody ... drug conjugate programs. About CytomX Therapeutics ...
(Date:5/5/2015)... Hills, MI (PRWEB) May 05, 2015 ... premier Parker Hannifin distributor, announces the launch of ... provide fleet operators with a convenient way to ... maintenance products . , The new ... to 100,000 vehicles with direct access to high ...
(Date:5/5/2015)... Synedgen Inc. is pleased to announce the ... , Dr. Nguyen brings to Synedgen critical regulatory expertise ... as it moves forward in the FDA regulatory processes ... years. Dr. Nguyen will lead the management of nonclinical ... that must be completed in order to initiate human ...
Breaking Biology Technology:Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3Exotic Automation & Supply Launches Ecommerce Website 2Synedgen Announces the Appointment of Regulatory Affairs Manager 2
... UPPSALA, Sweden and WILMINGTON, Mass., Aug. 31 Nico,Pijls, ... present the,benefits of measuring coronary pressure, or Fractional Flow ... a workshop at the European,Society of Cardiology (ESC) Congress ... Radi Medical Systems, will take place at,12:45 p.m. CEST ...
... Calif., Aug. 30 Cepheid (Nasdaq:,CPHD) will present ... at the Four Seasons Hotel, Boston, September 5 ... and Senior Vice President, Finance and,Chief Financial Officer, ... ET on,September 7. The webcast, along with ...
... 30 Verenium,Corporation (Nasdaq: VRNM ), a leading ... development of high-performance specialty,enzymes, announced today that Carlos A. ... presenting at the Cowen and Company Clean,Energy Conference. The ... Thursday, September 6, 2007 and will take place at ...
Cached Biology Technology:Interventional Cardiologists Nico Pijls, Bernard De Bruyne to Discuss Benefits of Measuring Coronary Pressure in Improving Multivessel PCI at ESC Congress 2007 2Cepheid to Present at Thomas Weisel Partners Healthcare Conference 2Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference 2Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference 3
...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
6-keto Prostaglandin F1α EIA Antiserum 6-keto-PGF1alpha EIAs prostaglandins antisera enzyme immunoassays reagents 6-keto-PGF1.alpha....
Ephrin A4...
Biology Products: