Navigation Links
Better viewing through fluorescent nanotubes when peering into innards of a mouse
Date:5/27/2011

Developing drugs to combat or cure human disease often involves a phase of testing with mice, so being able to peer clearly into a living mouse's innards has real value.

But with the fluorescent dyes currently used to image the interior of laboratory mice, the view becomes so murky several millimeters under the skin that researchers might have more success divining the future from the rodent's entrails than they do extracting usable data.

Now Stanford researchers have developed an improved imaging method using fluorescent carbon nanotubes that allows them to see centimeters deep into a mouse with far more clarity than conventional dyes provide. For a creature the size of a mouse, a few centimeters makes a great difference.

"We have already used similar carbon nanotubes to deliver drugs to treat cancer in laboratory testing in mice, but you would like to know where your delivery went, right?" said Hongjie Dai, a professor of chemistry. "With the fluorescent nanotubes, we can do drug delivery and imaging simultaneously in real time to evaluate the accuracy of a drug in hitting its target."

Researchers inject the single-walled carbon nanotubes into a mouse and can watch as the tubes are delivered to internal organs by the bloodstream.

The nanotubes fluoresce brightly in response to the light of a laser directed at the mouse, while a camera attuned to the nanotubes' near infrared wavelengths records the images.

By attaching the nanotubes to a medication, researchers can see how the drug is progressing through the mouse's body.

Dai is the one of the authors of a paper describing the research published online this month in Proceedings of the National Academy of Sciences.

The key to the nanotubes' usefulness is that they shine in a different portion of the near infrared spectrum than most dyes.

Biological tissues whether mouse or human naturally fluoresce at wavelengths
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Better buildings for extreme climates will be focus of researchers talk
2. Reforestation research in Latin America helps build better forests
3. Californias draft Bay Delta conservation plan incomplete; needs better integration to be more scientifically credible
4. Damaged hearts pump better when fueled with fats
5. Physical and emotional health of older couples linked for better or worse, study finds
6. Food safety in Canada is lax and needs better oversight, says CMAJ
7. People control thoughts better when they see their brain activity: UBC study
8. Science 101: Different teaching fosters better comprehension
9. A better understanding of the aging immune system
10. Getting closer to a better biocontrol for garden pests
11. In the race of life, better an adaptable tortoise than a fit hare
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Better viewing through fluorescent nanotubes when peering into innards of a mouse 
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "iPhone 5S Fingerprint ... Report" report to their offering. ... the acquisition of AuthenTec in July 2012, Apple ... 5S. It is currently the only device of ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems ... http://photos.prnewswire.com/prnh/20130307/600769 The North American ... CAGR of 3.6% from 2014 to 2019. Although the ... Canada is expected to grow ...
(Date:12/19/2014)... Calif. , Dec. 18, 2014  23andMe, Inc., ... of a study that pinpoints fine-scale differences in genetic ... States . Since immigrants first arrived ... United States has served as a meeting ... how American history and the ongoing mixing of peoples ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... of Earth observation missions expanding, it makes sense ... mission control from a combined Dedicated Control Room. ... and generating improved economic returns. , Flight control ... out of a combined Earth Observation (EO) Dedicated ...
... today announced details of a membership agreement with BioMed ... by its researchers. Pfizer,s BioMed Central membership arrangement ... for any researcher employed or funded by Pfizer when ... Central,s 190+ peer-reviewed open access journals. By funding open ...
... down on a Honduran naval boat as it criss-crossed the ... Central Americas most important seaports. Aboard the vessel, Miguel ... the distant horizon with some hint of concern on his ... the last few readings were definitely off. Miguel, along ...
Cached Biology News:ESA's Earth observation missions: Sharing teams and facilities boosts efficiency 2ESA's Earth observation missions: Sharing teams and facilities boosts efficiency 3Searching for pollution in the Caribbean 2Searching for pollution in the Caribbean 3Searching for pollution in the Caribbean 4Searching for pollution in the Caribbean 5Searching for pollution in the Caribbean 6Searching for pollution in the Caribbean 7Searching for pollution in the Caribbean 8
(Date:12/19/2014)... -- Naurex Inc., a biopharmaceutical company leveraging its unique ... central nervous system, today announced that Norbert Riedel ... at the 33 rd annual J.P. Morgan Healthcare ... p.m. PST on Tuesday, January 13, 2015, at the ... About Naurex Inc. ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 ... nation’s leading specialty pharmacies, has an expanded team ... clinical pharmacy consultants for prescriber offices in their ... , “We have a variety of Regional ... example, those specializing in hepatitis C help prescribers ...
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 iLab ... announced the appointment of Siri Bryant as the new ... new Director of Core Implementations. These two new leadership ... outstanding customer service by ensuring that iLab continues to ... “In the last four years, iLab has been deployed ...
(Date:12/19/2014)... 18, 2014 Egenix, Inc. is pleased to announce ... of the Board, to succeed Donald Fresne ; Mr. ... continue as a member of the Board.  In recognition of ... the company over almost twenty years, the Board designated Mr. ... Directors has established a Search Committee to find a suitable ...
Breaking Biology Technology:Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... businesses will receive funding for their technology development projects through ... , , BioSystem Development LLC of Middleton, will receive ... protein analysis. The company will use this award to finish ... university spin-off, we have not had the benefit of ...
... David Redick knows something about venture capital, having received ... entrepreneur. , ,Now Redick, a longtime denizen of Silicon ... the other side of the aisle with Badger ... focused on providing early stage funding and management services ...
... voted late Tuesday night to amend a bill granting ... newly created human embryonic stem cells would be denied. ... firms that do any research involving the destruction of ... cells from them after August 9, 2001. It ...
Cached Biology Technology:New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 2New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 3Bill would deny tax credits to firms creating stem-cell cultures 2
... entered the next frontier of cell-based High ... Cellomics, Inc. The drug discovery process will ... automated solutions systems and Cellomics‘ HCS technology, ... sub-cellular level. The integration of these systems ...
... The RC DC protein assay reagents package is ... of reducing agents and detergents. The RC DC ... includes reagents sufficient for 500 standard assays: 250 ... II, 250 ml alkaline copper tartrate solution, 2 ...
... is a post-translational modification that plays ... including immune regulation, inflammation, cell-to-cell adhesion, ... developed two lectin based Glycoprotein Isolation ... Germ Agglutinin (WGA), that allow isolation ...
... Trans-Blot cell and PowerPac Basic power supply are ... The Mini Trans-Blot cell accommodates two 7.5 x ... cassettes, modular electrode assembly, Bio-Ice cooling unit, buffer ... pads. The PowerPac basic power supply, 100-120 and ...
Biology Products: