Navigation Links
Better preparedness against Tamiflu-resistant influenza viruses
Date:12/9/2013

Swedish researchers in Ume and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious consequences in the event of an influenza pandemic. With more than 14 million SEK from the Swedish Research Councils Formas and VR, the research team will now continue their studies with a focus on alternative antiviral drugs.

Influenza is a viral respiratory infection that spreads rapidly and cause widespread epidemics. A severe influenza pandemic is a major health problem and treatment with antiviral medications is a central part of the preparedness plan. Tamiflu is the most widely used drug.

Hanna Sderstrm, environmental chemist and researcher at Ume University and Josef Jrhult, infectious disease physician and researcher at Uppsala University, together with Bjrn Olsen, professor at Uppsala University and Shaman Muradrasoli, researchers at SLU, Uppsala, have with a multidisciplinary approach followed what happens if Tamiflu comes out in nature.

"Our results show that Tamiflu's active metabolite, secreted by human urine, is not removed in traditional wastewater treatment plants. We have been able to trace Tamiflu in river water in Japan during the flu season 2007/ 08 as well as in Europe during the influenza pandemic 2009. Japan is the country that uses most antiviral drugs in the world during seasonal flu," says Hanna Sderstrm.

Based on the fact that dabbling ducks are the natural host for influenza viruses and that they often swim near the treatment plants, the researchers have examined whether influenza viruses in ducks exposed to Tamiflu via their bath and drinking water develops resistance.

"When ducks swim in water with environmentally relevant concentrations their influenza virus develop resistance. If a resistant influenza virus is spread to humans and causes a pandemic, this is a serious threat to public health since it takes many months to produce vaccine. We are therefore referred to the use of antiviral drugs during a pandemics first wave," says Josef Jrhult.

Today, Relenza is the drug that constitutes the first hand option when Tamiflu has no effect. It is therefore very likely that Relenza, and new antiviral drugs that are not yet out on the Swedish market, will be used more if the Tamiflu resistance increase.

With the money that the research group will receive they want to be one step ahead and develop a national knowledge center on effects of antiviral drug in the environment and the risk of development of resistant viruses.

"It is particularly important to examine the risk of resistance development before the drug is used more extensively so that we can adjust the prescription and implementation of a sound preparedness planning for future pandemics," says Josef Jrhult.

Another part of the research focuses on better waste water treatment. Ozone treatment has proven to be an effective method for treating waste water containing Tamiflu and the researchers will investigate whether the method can work for other antiviral drugs as well.


'/>"/>

Contact: Hanna Söderström
hanna.soderstrom@chem.umu.se
46-702-200-994
Umea University
Source:Eurekalert  

Related biology news :

1. More logging, deforestation may better serve climate in some areas
2. Fruit flies with better sex lives live longer
3. New clues to memory formation may help better treat dementia
4. NREL test helps make moisture barriers better
5. 5 tips for a better Thanksgiving: A new video by the American Chemical Society
6. Antibiotic resistance is a international issue that better education can address
7. Better batteries through biology?
8. Cancer cant hide; better heart shocks; mechanical leeches
9. Single-cell genome sequencing gets better
10. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
11. Crafting a better enzyme cocktail to turn plants into fuel faster
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Better preparedness against Tamiflu-resistant influenza viruses
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... firm Parks Associates announced today that Tom Kerber , ... Meeting , October 11 in Scottsdale, Arizona . Kerber ... smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon ... awards honoring scientists who have made outstanding contributions to analytical chemistry ... Pittcon 2018, the world’s leading conference and exposition for laboratory science, which will ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... Phoenix, Arizona (PRWEB) , ... ... ... than 15 years’ experience providing advanced instruments and applications consulting for microscopy ... the in-house expertise in application consulting, Nanoscience Analytical offers a broad range ...
Breaking Biology Technology: