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Better blood transfusions for preterm babies
Date:11/26/2012

Results of new research from the University of Adelaide are a promising step forward in helping to improve the quality of life-saving blood transfusions for preterm babies, by reducing the likelihood of adverse inflammatory responses to the blood.

Blood transfusions are among the most common medical procedures experienced by preterm babies, who are often anemic and suffer blood loss.

Researchers from the University of Adelaide's Robinson Institute studied 28 preterm babies (at 28 weeks' gestation or less) who were given packed red blood cell transfusions. The results of this study are now published in the journal Pediatric Research.

"Blood transfusions are a safe and life-saving medical procedure - they are an important part of modern-day medical care," says the lead author, Dr Michael Stark from the University of Adelaide's Robinson Institute.

"It has been suggested that blood transfusions themselves may be associated with medical complications that are unrelated to the reason for which the transfusion is given, and we don't really know why that is.

"These associations include bronchopulmonary dysplasia and necrotizing entercolitis, inflammatory conditions that affect the lungs and gut of very preterm babies."

The researchers have found a potential mechanism associated with the inflammatory response in the body.

"Within two to four hours of preterm babies receiving a blood transfusion, we have seen elevated levels of cytokines and chemokines - signaling cells - that stimulate inflammatory responses in the body," Dr Stark says.

"We believe that the bioactive components of packed red blood cell transfusions are initiating or amplifying these inflammatory
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Contact: Michael Stark
michael.stark@adelaide.edu.au
61-883-131-325
University of Adelaide
Source:Eurekalert

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