Navigation Links
Better approach to treating deadly melanoma identified by scientists
Date:12/19/2012

Scientists at The University of Manchester have identified a protein that appears to hold the key to creating more effective drug treatments for melanoma, one of the deadliest cancers.

Researchers funded by Cancer Research UK have been looking at why new drugs called "MEK inhibitors", which are currently being tested in clinical trials, aren't as effective at killing cancer cells as they should be.

They discovered that MITF - a protein that helps cells to produce pigment but also helps melanoma cells to grow and survive - is able to provide cancer cells with a resistance to MEK inhibitors.

Dr Claudia Wellbrock and her team at the Wellcome Trust Centre for Cell-Matrix Research compared human melanoma cells that respond to the drug to cells that don't. They discovered that the cells that didn't respond to the drug contained higher levels of the protein SMURF2.

The researchers reduced the level of SMURF2 in the melanoma cancer cells and then treated the tumour with the MEK inhibitor. They found a 100 fold increase in the sensitivity of the cells to the drug. It appears that removing SMURF2 radically decreases the level of MITF in melanoma cells, making the MEK inhibitor a lot more powerful.

Using mice with tumours the team found that over a three week period there was a substantial decrease in tumour growth when the removal of SMURF2 was used in combination with MEK inhibitors.

Dr Wellbrock says: "Much of cancer research is now focussed on finding new drug combinations. It's recognised that cancers frequently find new ways to combat even the most novel and highly efficient drug treatments, so we are now focussing on targeting the mechanisms that allow the cancer cells to overcome the drug effects. We're very excited about the potential for this new approach that has proved to be so effective in our experiments."

One of the drawbacks of the MEK inhibitor drug is that it targets all cells. MEK (MAP/ERK
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. New methods for better purification of wastewater
2. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
3. UNH researchers find African farmers need better climate change data to improve farming practices
4. Giant squids giant eyes: The better to see hungry whales with
5. Improved loblolly pines better for the environment, study finds
6. Fish larvae find the reef by orienting: The earlier the better
7. Intensive kidney dialysis indicates better survival rates than conventional dialysis
8. Modern hybrid corn makes better use of nitrogen, study shows
9. Bigger gorillas better at attracting mates and raising young
10. Better housing conditions for zebrafish could improve research results
11. Better plants for biofuels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... -- Leading Biometric companies aim to provide consumers ... transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... ), Google Inc. (NASDAQ: GOOG ), Microsoft Corporation ... EBAY ) and MasterCard Inc. (NYSE: MA) NXT-ID, ... authentication company focused on the growing mobile commerce is pleased ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... And to survive, such marine predators need to sustain the right ... a new study by researchers from the University of British Columbia ... the online journal PLOS ONE , the study is the ... on the quality of their diets and this plays an important ...
... researchers, led by Dr. Frdric Charron, recently uncovered a ... discovery was made in collaboration with Dr. Alyson Fournier,s ... the prestigious scientific journal Neuron , this breakthrough ... repair and regenerate nerve cells following injuries to the ...
... are capped at their ends with special DNA structures ... act as a protective sheath. Telomeres are maintained through ... proteins. Researchers at The Wistar Institute have defined the ... Understanding how telomeres keep chromosomes and by ...
Cached Biology News:A step forward in regenerating and repairing damaged nerve cells 2It takes two to tangle: Wistar scientists further unravel telomere biology 2
(Date:11/27/2014)... , November 27, 2014 ... the management of tooth decay, today announces that ... its Calcivis® Caries Activity Imaging System. ... sophisticated medical device and consumable combination designed to ... (tooth decay). It involves a unique, proprietary bioluminescence ...
(Date:11/26/2014)... 2014 Deep Research Report on ... in-depth research report on the Ammonium Bifluoride market, ... classification, application, and industry chain structure as well ... market analysis, including China’s domestic market as well ... China, Japan etc. regions) industry analysis covering macroeconomic ...
(Date:11/26/2014)... and PHILADELPHIA , Nov. ... most demanding and unforgiving environments. Human exploration of space ... performance to ensure mission safety and success, and prevent ... performance for mission success, little is known about how ... of cognition are primarily affected. Now, Penn ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 PMG Research, ... Board. PMG Research is a network of sites that provide ... to over 2 million patient lives through its partnerships with ... comprised of 11 hub site locations in the Southeastern United ... first term of the board will be held ...
Breaking Biology Technology:Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3
... 1:30 p.m. Eastern Time Today, GAITHERSBURG, Md., March ... financial results and corporate progress for,the full year ended ... we have further demonstrated that Iomai,s,vaccine and immunostimulant patches ... president and chief executive officer,of Iomai. "This lays the ...
... HILLS, Mass., March 6 Joseph F. Finn, ... of ActivBiotics, announced,today that the Office of Orphan ... has granted Orphan Drug Designation for M40403 for ... oral mucositis (OM),in cancer patients., The development ...
... EntreMed, Inc.,(Nasdaq: ENMD ), a clinical-stage pharmaceutical ... inflammatory diseases, today,reported results for the three months ... http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ), For fiscal year ... 2006. For the year ended December 31, 2007, ...
Cached Biology Technology:Iomai Announces Year-End 2007 Financial Results and Business Progress 2Iomai Announces Year-End 2007 Financial Results and Business Progress 3Iomai Announces Year-End 2007 Financial Results and Business Progress 4Iomai Announces Year-End 2007 Financial Results and Business Progress 5Iomai Announces Year-End 2007 Financial Results and Business Progress 6ActivBiotics Receives FDA Orphan Drug Designation for Superoxide Dismutase Mimetic, M40403, in Oral Mucositis of Cancer 2ActivBiotics Receives FDA Orphan Drug Designation for Superoxide Dismutase Mimetic, M40403, in Oral Mucositis of Cancer 3EntreMed Reports Fourth Quarter and Year-End 2007 Financial Results 2EntreMed Reports Fourth Quarter and Year-End 2007 Financial Results 3EntreMed Reports Fourth Quarter and Year-End 2007 Financial Results 4EntreMed Reports Fourth Quarter and Year-End 2007 Financial Results 5
Rabbit polyclonal to 13,14 dihydro 15 keto Prostaglandin E2 ( Abpromise for all tested applications)....
Arginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors....
... WinList come straight from the folks who ... automatic region positioning, N-Stat regions, and presentation-quality ... thoughtful conversations, and careful design. Of course, ... are still there, too. WinList leads the ...
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Biology Products: