Navigation Links
Better CMT outcome measurement is Wayne State University physician's goal
Date:12/7/2011

ves with vitamin C in large quantities, and researchers wanted to see if the therapy actually was safe and effective in a randomized trial.

Trials in Australia, France, Italy, England and the Netherlands concluded that ascorbic acid, given as a medication, was safe but ineffective.

"One concern with those trials was that outcome measures varied," Ramchandren said. Some researchers measured a combined outcome score called the Charcot-Marie-Tooth Neuropathy Score, which was developed by Michael Shy, M.D., WSU professor of neurology and Ramchandren's mentor for her current study. Others looked at whether the speed of nerve conduction improved.

Because financial constraints typically limit trials to one or two years, Ramchandren said, an outcome measurement is needed that could change within that time period.

"A good outcome measure will show changes in scores in a short time period so that, when used in a trial, if a drug is effective, we should see those scores improve," she said. "However, if you use an outcome measure that barely budges in a short time period, there's not much chance you will get a dramatic improvement in scores, even if you have a good medication. So, with the recent CMT trials, it may very well be that vitamin C is ineffective, but we can't say for sure when there are doubts about what we are measuring."

With this grant, she will use data from an ongoing consortium study by Shy that collects natural history data on children and adult CMT patients to see how the disease progresses over time. Shy is mentoring Ramchandren as she develops a quality-of-life instrument to measure how CMT impacts children's lives.

Using a questionnaire format, Ramchandren will try to determine what kinds of physical activities CMT restrains. Questions also will address the disease's effects on social roles, such as playing with friends and interaction with families and teachers, as well as emotional behavior, depre
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Aggression prevents the better part of valor ... in fig wasps
2. Researchers new recipe cooks up better tissue phantoms
3. Better batteries
4. Space shuttle data leads to better model for solar power production in California
5. More power to the cranberry: Study shows juice better than extracts at fighting infections
6. Children with certain dopamine system gene variants respond better to ADHD drug
7. Gene variant leads to better memory via increased brain activation
8. Better ways to predict kidney disease risk for African Americans
9. National labs leading charge on building better batteries
10. Better planning required if EU is to meet energy targets
11. Location matters: For invasive aquatic species, its better to start upstream
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... ago when the supercontinent of Pangea was starting to break ... different kinds of reptiles called phytosaurs and rauisuchids were at ... believed the two top predators didn,t interact much as the ... the land. But those ideas are changing, thanks largely to ... published online in September in the German journal ...
(Date:9/29/2014)... has significant anti-tumour activity in patients with advanced ... disease has progressed after chemotherapy, according to phase ... in Madrid, Spain. , "Reports of lung ... interest because these mutations may be associated with ... lead author Dr David Planchard, pulmonary oncologist at ...
(Date:9/29/2014)... 2014 NXT-ID, Inc. (Nasdaq: NXTD ... authentication company focused on the growing mobile commerce market, ... been named the Company,s Vice-President and Chief Financial Officer ... as Chief Financial Officer. Mr. Pereira will continue to ... a Director. Mr. Miceli, age 56, has ...
Breaking Biology News(10 mins):Tooth buried in bone shows prehistoric predators tangled across land, sea 2Promising results shown with targeted approaches in subsets of non-small cell lung cancer 2Promising results shown with targeted approaches in subsets of non-small cell lung cancer 3NXT-ID, Inc. Names Vice-President and Chief Financial Officer 2NXT-ID, Inc. Names Vice-President and Chief Financial Officer 3
... Chalmers University of Technology have built a very simple ... directions, even though the antenna is smaller than the ... online journal Nature Communications this week ... very low concentrations of gases or biomolecules. A ...
... 2011 The Translational Genomics Research Institute (TGen) is ... $3.5 million grant from Susan G. Komen for the ... form of this cancer that disproportionately affects African-Americans. ... of physicians and scientists called Promise Grants, multi-million dollar, ...
... of Utah researchers have discovered a new class of compounds ... and inhibit it from infecting cells an early step ... virus. Development and laboratory testing of the potential new ... a study set for online publication by Friday in the ...
Cached Biology News:Bimetallic nanoantenna separates colors of light 2TGen breast cancer research benefits from $3.5 million Komen award 2TGen breast cancer research benefits from $3.5 million Komen award 3Targeting HIV's sugar coating 2Targeting HIV's sugar coating 3
(Date:9/30/2014)... 2014 The custom stainless steel fabrication ... Show 2014. The Boston Area Chapter of ISPE (International ... day-long event for Wed., Oct. 1 at Gillette Stadium ... the largest in ISPE Boston’s long history, with more ... attendees expected. , HOLLOWAY AMERICA President David Simpson ...
(Date:9/30/2014)... Lyme Research Alliance (LRA), the ... at universities, today announced the awarding of seven grants ... and cure for Lyme and other tick-borne diseases. ... in its history—over 20 grant proposals—a 100 percent increase ... to receive so many solid applications from talented scientists ...
(Date:9/30/2014)... 30, 2014 SoundConnect, ... company is dedicated to supporting business communication solutions, ... Julie Power, a carrier services specialist ... solutions stays connected and productive at all times. ... movement of businesses to cloud communications services. ...
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4SoundConnect Expands Carrier Services Division 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2
... Therapeutics,Inc. (Nasdaq: IMRX ), a biopharmaceutical company ... financial,results for the first quarter ended March 31, ... Highlights:, -- Entered into agreement with Abbott ... obligation under non-recourse promissory note issued in connection ...
... Spain, May 15 Forest,Laboratories, Inc. (NYSE: ... a webcast to discuss aclidinium bromide clinical and ... Annual Congress.,The webcast, which will include a slide ... May 21, 2008 at 9:30am New York time, ...
... Care Advisory Panel reacts to CMS final rule; ... identifies challenges, recommends ... Industries, Inc. and,the International Expert Wound Care Advisory ... to Improve Pressure,Ulcer Prevention and Treatment: Implications of ...
Cached Biology Technology:ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 2ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 3ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 4ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 5ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 6ImaRx Therapeutics Reports First Quarter Ended 2008 Financial Results 7Forest Laboratories, Inc. and Laboratorios Almirall, S.A. to Host Webcast to Discuss Aclidinium Bromide Data Presentations at the American Thoracic Society Annual Congress 2International Wound Care Experts, Medline Announce Pressure Ulcer Prevention Consensus Paper 2International Wound Care Experts, Medline Announce Pressure Ulcer Prevention Consensus Paper 3
Request Info...
Request Info...
... Nebulizers are available in two product models - ... two models is that the 6000AT+ includes a ... drier aerosol for improved detection limits and reduced ... a range of elements by 10-40 times. Note ...
...
Biology Products: