Navigation Links
Better CMT outcome measurement is Wayne State University physician's goal
Date:12/7/2011

A Wayne State University physician is seeking a better way to determine the effectiveness of treatments for Charcot-Marie-Tooth disease (CMT), or inherited sensory-motor neuropathy, a disease that afflicts one in 2,500 people.

Sindhu Ramchandren, M.D., assistant professor of neurology in WSU's School of Medicine, believes the current lack of effective treatments for CMT may be because researchers are measuring the wrong outcomes. With a four-year, $661,000 Mentored Career Development Award from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, she is working to develop an outcome measurement that accurately reflects CMT progression in children.

CMT refers to a heterozygous group of diseases caused by mutations in more than 50 genes. One of the most common genetic nerve diseases, it affects more than 120,000 Americans and causes progressive muscle weakness, painful foot deformities and walking difficulty.

As the disease progresses, weakness and muscle atrophy occur in the hands, resulting in difficulty with fine motor skills. Symptoms vary from patient to patient, with pain ranging from mild to severe. Some rely on foot or leg braces or other orthopedic devices to maintain mobility.

The identification of disease-causing genes has made the development of rational therapy a possibility in CMT. However, the lack of outcome measures to assess treatment effects in clinical trials is currently limiting therapeutic advances for CMT.

One of the most recent trials spanned several countries and involved ascorbic acid, or vitamin C, after animal models showed dramatic improvement in functioning.

"That gave a lot of hope to a lot of people," Ramchandren said.

One criticism of that group of trials is that they were rushed and used different outcome measures, but she said the rush was necessary because of the concern that CMT patients might medicate themsel
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Aggression prevents the better part of valor ... in fig wasps
2. Researchers new recipe cooks up better tissue phantoms
3. Better batteries
4. Space shuttle data leads to better model for solar power production in California
5. More power to the cranberry: Study shows juice better than extracts at fighting infections
6. Children with certain dopamine system gene variants respond better to ADHD drug
7. Gene variant leads to better memory via increased brain activation
8. Better ways to predict kidney disease risk for African Americans
9. National labs leading charge on building better batteries
10. Better planning required if EU is to meet energy targets
11. Location matters: For invasive aquatic species, its better to start upstream
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2015)... BELLEVUE, Wash. , Aug. 25, 2015 /PRNewswire/ ... announced today it will unveil its "Guardian S" snake ... the National Tactical Officers Association Conference on August 30 ... S is the first-ever commercially available energetically autonomous snake ... and in-field trials and is protected by more than ...
(Date:8/20/2015)... ., Aug. 20, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... it has joined The Smart Card Alliance and the ... Card Alliance and the Smart Card Alliance Latin America ... to industry peers and thought leaders promoting adoption of ...
(Date:8/12/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is proud to announce that ... eClinical technology platform, has led the way to significant ... of 2015.   Q2 2015 and Q1 2015 were, ... contract value sold in the company,s 15 year history.  ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4MedNet Solutions Experiences Explosive Corporate Growth 2
... which become accustomed to ignoring genetically engineered chemical alarms ... become easy prey for ladybugs. That,s good news for ... for Plant Research and Cornell University. ( Proceedings of ... The study, "Alarm pheromone habituation in Myzus persicae ...
... Research is continually emerging on the impacts ... ecosystems and communities. Ecological scientists will discuss widespread ... plants in the wild to the implications of ... exploring society,s reactive mode toward environmental disasters in ...
... cell division, microtubules emanating from each of the spindle ... Scientists at the European Molecular Biology Laboratory (EMBL) in ... the extent of this overlap. In a study published ... reconstruct such anti-parallel microtubule overlaps in vitro, and identify ...
Cached Biology News:Apathetic aphids with attitude become easier prey for ladybugs 2Scientists find new evidence of genetically modified plants in the wild 2Scientists find new evidence of genetically modified plants in the wild 3Scientists find new evidence of genetically modified plants in the wild 4Constant overlap 2
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
(Date:8/26/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended June 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... to our Oral Amp B program, rapidly advancing ... Andrew Rae , President & CEO of ...
(Date:8/26/2015)... MIAMI , Aug. 26, 2015  The ... at the University of Miami Miller School of ... its clinical trial to test for the first ... was successfully completed.  This FDA approved Phase I/II ... islet transplantation and is an important first step ...
(Date:8/26/2015)... 26, 2015 Israel Proves Its Place in ... st place  Wayerz comes in 5 th ... by venture capital fund JVP, with Chinese consulting firm ... China , Israel , ... Impressive achievement for the Israeli representatives in the final round ...
Breaking Biology Technology:Marken Ensures Safe Transportation Of Select Agents And Toxins 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6
... havoc on bacteria as well as humans and, just like ... Professor John van der Oost, at the Society for General ... system" could be used to keep industrial microbes at peak ... Wageningen University in the Netherlands have spent the last three ...
... ... minutes post-dose using electronic patient diary data , ... PITTSBURGH, PA (Vocus) March 31, 2010 -- invivodata, ... global clinical research, today announced that its DiaryPRO® field-based ePRO solution captured ...
... system senses and tracks down infection in the body by ... cells manipulate their movement in response to external signals could ... but also how cancer cells spread through the body and ... Society for General Microbiology,s spring meeting in Edinburgh, Dr Holger ...
Cached Biology Technology:invivodata Delivers Critical Symptom Relief Data in INSYS Therapeutics' Breakthrough Cancer Pain Trial 2invivodata Delivers Critical Symptom Relief Data in INSYS Therapeutics' Breakthrough Cancer Pain Trial 3How immune cells 'sniff out' bacteria 2
ATGL Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Human sIL-2R/CD25 ELI-PAIR Kit...
Rabbit polyclonal to Factor IX ( Abpromise for all tested applications). entrezGeneID: 2158 SwissProtID: P00740...
Rabbit polyclonal to Phosphothreonine-Proline / Phosphoserine-Proline ( Abpromise for all tested applications)....
Biology Products: