Navigation Links
Beth Israel Deaconess Medical Center's Harold F. Dvorak, M.D., wins Gairdner Award
Date:3/28/2014

BOSTON Harold F. Dvorak, MD, senior investigator in the Center for Vascular Biology Research at Beth Israel Deaconess Medical Center (BIDMC) and former chairman of BIDMC's Department of Pathology, is one of eight scientists to win the 2014 Canada Gairdner Awards, which recognize some of the most significant medical discoveries from around the world. Awarded by the Gairdner Foundation, based in Canada, the awards are considered among the most prestigious international awards in medical research.

Dvorak, the Mallinckrodt Distinguished Professor of Pathology at Harvard Medical School, has been recognized for his landmark discovery of vascular endothelial growth factor (VEGF) and the development of effective anti-VEGF therapy for cancer and wet macular degeneration. VEGF is a key molecular mediator of new blood vessel formation.

The Gairdner Awards recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. This year's winners showcase a broad range of new medical discoveries related to cancer, cardiovascular disease, immunotherapy and human parasitic diseases.

"Hal Dvorak's groundbreaking discovery of the VEGF signaling protein helped form the basis for the field of angiogenesis, and led to an entirely new means of treating cancer and other diseases by starving blood supply to tumors," says BIDMC Chief Academic Officer Vikas P. Sukhatme, MD, PhD. "Hal is truly a pioneer among cancer researchers and this honor reflects a tremendous body of work that he and his colleagues have conducted over the years. The idea that cancer is a wound that does not heal, as suggested by Hal years ago, has had profound therapeutic implications that are only now starting to be truly recognized."

Dvorak's initial characterization of VEGF as a permeability enhancing factor further suggested that antibodies to it may be effective in treating states of vascular leak, including macular degeneration, which has proven to be the case. "Hal's studies also formed the framework for understanding the cause of preeclampsia, the dangerous complication of pregnancy," adds Sukhatme. "This discovery was made here at BIDMC by Ananth Karumanchi, a colleague in the Center for Vascular Biology Research for whom Hal has been an important mentor, as he has to so many young scientists. On a personal note, Hal is one of the most gracious and collaborative scientists that I have had the pleasure of meeting."

In 1983, Dvorak reported a tumor-derived protein that caused the cells lining tumor blood vessels to become hyperpermeable or "leaky" to circulating molecules. He called the protein vascular permeability factor (VPF), and subsequently demonstrated that VPF was also secreted by many normal cells and plays a key role in wound healing and chronic inflammatory diseases. As the Gairdner Foundation notes, "Dr. Dvorak's research demonstrated that most malignant tumors make VEGF, which assists the tumors to grow beyond minimal size by forming new blood vessels and connective tissue support as in wound healing."

"Dr. Dvorak's work enabled major advances in our understanding of several key physiological processes," adds BIDMC Chairman of Pathology Jeffrey Saffitz, MD, PhD. "I speak on behalf of our entire department in expressing our extreme pride in this award and in Dr. Dvorak's ongoing work in the field of angiogenesis."

A graduate of Princeton University and Harvard Medical School, Dvorak is a fellow of the American Association for the Advancement of Science and of the National Foundation for Cancer Research (NFCR). His numerous honors include the 2006 Albert Szent-Gyorgyi Prize for Progress in Cancer Research from the NFCR, the 2005 Grand Prix Lefoulon-Delalande-Institut de France Award, and the 2002 Rous-Whipple Award from the American Society of Investigative Pathology.

The Canada Gairdner Awards were created in 1959 to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. The awards will be presented at a dinner in Toronto in October 2014.


'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Related biology news :

1. Israel Prize in Medicine awarded to Hebrew University developer of Alzheimers drug
2. Finding Israels first camels
3. Malaria conference looks to Israels past for modern solutions
4. GSA Bulletin posts new studies from China, Egypt and Israel, Argentina, Mexico, California, Appalachia
5. Genetic study proves Israels wild boars originated in Europe
6. An extinct frog makes a comeback in Israel
7. Israel Prize awarded to Tel Aviv University biochemist
8. EU Commission selects Human Brain Project, with Israelis as partners
9. Undersea gas leaks off Israels coast are discovered by University of Haifa researchers
10. Israels first Green Roofs Ecology research center dedicated at University of Haifa
11. Israel to set up National Center for Mediterranean Sea Research, headed by U of Haifa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... Jan. 22, 2016 ... of the "Global Biometrics Market in ... offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ...
(Date:1/20/2016)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce the attainment of record-setting ... result of the company,s laser focus on (and growing ... it,s comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... MedNet growth achievements in 2015 include: , ...
(Date:1/15/2016)... 15, 2016 Recent publicized breaches in cyber ... new ways to ensure data security and user authentication ... and Android that ties a user,s mobile ... into a hardware authorization token. Customer service agents who ... on their KodeKey enabled device to verify their identity. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Vermillion, Inc. (NASDAQ: VRML ... today announced the formation of the Steering Committee for ... --> Pelvic masses can present physicians ... management. Once pregnancy is ruled out, pelvic masses may ... advanced endometriosis, benign ovarian tumors and gastrointestinal and urinary ...
(Date:2/11/2016)... 2016  Wellcentive today announced it has been ... -based community care organization (CCO) with more ... quality reporting and care management solutions and services. ... of quality managers, analysts and care managers while ... serving FamilyCare members. Oregon ...
(Date:2/11/2016)... 2016   BioInformant announces the February 2016 ... Products, Opportunities, Tools, and Technologies – Market Size, Segments, ... The first and only ... industry, BioInformant has more than a decade of historical ... by stem cell type. This powerful 175 page global ...
(Date:2/10/2016)... Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... announce that Mitsui & Co. Ltd., its partner in ... plant, is investing an additional CDN$25 million in the ... stake from 30% to 40%.  Mitsui will also play ... produced in Sarnia , providing dedicated ...
Breaking Biology Technology: