Navigation Links
Berkeley scientists find new way to get physical in the fight against cancer
Date:3/11/2010

h a combination of Total Internal Reflection Fluorescence (TIRF), reflection interference and epifluorescence imaging techniques.

"Without the barriers, the clusters of EphA2/ephrin-A1 signaling complexes were transported to the center of the cellsupported membrane junction, but with the barriers in place, there was an accumulation of clusters at the barrier boundaries," Groves says. "This resulted in a spatial reorganization that altered the cell's biochemical behavior."

Quantitative analysis of these changes to the spatial organization of the EphA2/ephrin-A1 signaling complexes across the library of breast cancer cell lines revealed a strong correlation with the potential for metastasis. Since the patterned metal lines in the silica substrate are analogous to the stiffness, texture and other elastic and mechanical properties of tissue, as well as to internal structures within the cell membrane, the results of this study point to intriguing new possibilities for breast and other cancer therapies.

"It's possible that the force-sensing process itself could provide a target for therapeutic intervention," says Groves. "We're also excited about finding targets for which there may be drugs that have already been developed but are now being used to treat diseases other than cancer. Given the sensitivity to mechanical forces displayed by the EphA2/ephrin-A1 signaling complexes, it is possible these existing drugs could be redirected to the treatment of cancer."


'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Berkeley Lab researchers participate in Homeland Security study of subway airflow
2. Berkeley Lab lends expertise to India to promote energy efficiency
3. Nanyang Technological University and University of California, Berkeley pursue research alliance
4. UC Berkeley virologist named Keck Distinguished Young Scholar
5. Berkeley researchers identify photosynthetic dimmer switch
6. Way to go: MBL scientists identify driving forces in human cell division
7. A convincing mimic: Scientists report octopus imitating flounder in the Atlantic
8. Scientists locate apparent hydrothermal vents off Antarctica
9. MMS and NOAA scientists study prey of Gulf of Mexico sperm whales
10. Scientists find community involvement, not only enforcement, drives success of marine reserves
11. Scientists identify age-associated defects in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Berkeley scientists find new way to get physical in the fight against cancer
(Date:9/19/2014)... professor will study the unique bioelectric signaling system of ... people,s health. The OU researcher is working to ... produce the signals used to map the world around ... rate of 500-600 discharges a second throughout their lives. ... are extreme, but necessary for survival. , "There is ...
(Date:9/19/2014)... legume plants regulate their symbiotic relationship with soil ... through the plant structure from leaves into the ... in the roots. This collaborative study was conducted ... Biology, the Graduate University for Advanced Studies (SOKENDAI), ... in Japan. , Legumes, an important plant ...
(Date:9/18/2014)... ANTONIO, September 18, 2014 New research into the ... causes a severe hemorrhagic disease in humans similar to ... essential for CCHFV infection. This discovery has the potential ... the pathogen. , The research, reported in ... Pathogens and conducted by scientists at the Texas ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Research milestone in CCHF virus could help identify new treatments 2
... engineers have proposed a new environmentally friendly process for ... - potentially available from agricultural and forest waste, providing ... transportation sector." , The new approach modifies conventional methods ... from a "carbon-free" energy source, such as solar or ...
... study in PLoS Medicine has shown that children who ... children, and who have antigens (protein fragments from the ... infectious virus in their blood. Margaret Conner and colleagues ... obtained from hospitalized children with gastroenteritis and compared them ...
... transcendent entity answer prayer? , The answer, according to ... March journal Research on Social Work Practice, is “yes.?David ... the College of Human Services at Arizona State University, ... the effects of intercessory prayer ?or prayer that is ...
Cached Biology News:New biofuels process promises to meet all US transportation needs 2New biofuels process promises to meet all US transportation needs 3New biofuels process promises to meet all US transportation needs 4Does God answer prayer? ASU research says 'yes' 2
(Date:9/19/2014)... 2014 Biotech companies make announcements ... drug systems and advanced Laboratory Instrumentation. Companies in focus ... BDX ), Thermo Fisher Scientific Inc. (NYSE: ... RGDO ), Sangamo Biosciences Inc. (NASDAQ: ... Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" or the "Company") ...
(Date:9/19/2014)... -- Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology ... to manufacture proteins including biosimilar therapeutics, today announced that ... Annual NewsMakers in the Biotech Industry conference in ... chief executive officer of Pfenex, will provide an overview ... Friday, September 26, 2014 at 10:00 a.m. EDT/7:00 a.m. ...
(Date:9/19/2014)... September 19, 2014 Barnhardt Manufacturing ... Label for its Organic Cotton . The USDA ... of renewable biobased ingredients meets or exceeds levels set ... composed in whole or in significant part of agricultural, ... allow our Organic cotton to be immediately identified as ...
(Date:9/19/2014)... Dublin ... announced the addition of the  "Micro Market Monitor ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... fastest-growing segments in the chromatography market. The market ... expected to reach $2.0 billion by 2019, at ...
Breaking Biology Technology:Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Pfenex to Present at Upcoming Industry Conference on September 26 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2
... NEOG ) has expanded its line of ... quickest test available for tetracycline residues,in milk. The ... treat,bovine mastitis, and includes tetracycline, chlortetracycline, and,oxytetracycline., ... the company,s widely used BetaStar(R) test for the ...
... Philadelphia Area -, PHILADELPHIA, Feb. 13 ... announced today the appointment of Chris Tihansky as,its ... Paris-based Mauna,Kea Technologies and develops and markets Cellvizio(R), ... care by eliminating the,need for unnecessary biopsies and ...
... Advance Nanotech, Inc.,(OTC Bulletin Board: AVNA), a leader in ... special meeting of shareholders held at,Company headquarters in New ... increase the authorized number of shares of Capital stock ... shares,present at the meeting were voted in favor of ...
Cached Biology Technology:Neogen Launches Quickest Test Available for Tetracyclines in Milk 2Chris Tihansky Appointed President of In Vivo Cellular Imaging Leader Cellvizio Inc. 2Advance Nanotech Announces Shareholder Proxy Vote Results 2Advance Nanotech Announces Shareholder Proxy Vote Results 3
...
...
MultiWash III w/ 12-portStandard Manifold...
... Sepharose High Performance, 5 ml. The ... in HiTrap Streptavidin columns for fast, ... packing into Tricorn 5/50 GL, XK ... scale purifications are required.Extremely useful for ...
Biology Products: