Navigation Links
Berkeley Lab scientists help develop promising therapy for Huntington's disease
Date:11/1/2012

delays the disease's progression.

Another intriguing line of defense could be in the form of therapies that protect mitochondria from chemically reactive molecules that contain oxygen. These molecules, called reactive oxygen species, inflict oxidative damage on mitochondria that disrupts their function and leads to cell death.

But defending mitochondria from reactive oxygen species is a tall order. That's because mitochondria are both the main target of these molecules, and a cell's primary source of them. In other words, mitochondria produce the very thing that damages them.

Researchers have studied whether dietary supplements of natural antioxidants such as vitamin E and coenzyme Q can mitigate the harmful effects of reactive oxygen species on mitochondria. Natural antioxidants don't target specific tissue within the body, however. And they've been shown to yield only marginal benefits in human clinical trials.

These lackluster results have driven scientists to develop synthetic antioxidants that specifically target mitochondria. A few years ago, University of Pittsburgh chemist Peter Wipf synthesized an antioxidant called XJB-5-131 that zeroes in on bacterial membranes, which are very similar to mitochondrial membranes. He also found that this compound dramatically improves cellular survival. But its effectiveness against neurodegenerative diseases was unknown.

That's where Cynthia McMurray's lab comes in. Several years ago, her team began exploring ways to study a genetic mutation that causes Huntington's disease. They've since developed a mouse model with this mutation that enables the scientists to evaluate how the disease affects mice, which is a fairly good proxy for humans. In addition, Zhiyin Xun learned how to isolate nerve terminals and mitochondria from a mouse's brain, enabling the scientists to study the organelle's role in the disease.

The scientists first injected Huntington's mice with XJB-5-131
'/>"/>

Contact: Dan Krotz
dakrotz@lbl.gov
510-486-4019
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Berkeley Lab scientists generate electricity from viruses
2. Berkeley Lab scientists help define the healthy human microbiome
3. Waves of Berkeley Lab responders deploy omics to track Deepwater Horizon cleanup microbes
4. UC Berkeley chemists installing first carbon dioxide sensor network in Oakland
5. UC Berkeley survey shows college campuses can make good bird havens
6. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
7. Queens scientists seek vaccine for Pseudomonas infection
8. Scientists produce eye structures from human blood-derived stem cells
9. American Society of Plant Biologists honors early career women scientists
10. Brandeis scientists win prestigious prize for circadian rhythms research
11. Scientists discover new method of proton transfer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Berkeley Lab scientists help develop promising therapy for Huntington's disease
(Date:7/11/2014)... Janeiro, Brazil- In the brains of all vertebrates, ... allows an electric or chemical signal to be ... synapses, which are the most abundant type of ... formation is crucial for learning, memory, perception and ... synapses critical for brain function. For instance, ...
(Date:7/10/2014)... -- Aware, Inc. (NASDAQ: AWRE ), a leading ... June 26, 2014 that its Board of Directors had ... or approximately $40 million in total.  The Board established ... payment date of July 24, 2014.  The Company was ... ex-dividend date for this special cash dividend.  An ex-dividend ...
(Date:7/10/2014)... -- NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the ... was interviewed on July 1 st on the ... . Mr. Pereira discusses the company,s next generation smart wallet ... the Wocket™ aims to replace a traditional wallet with a ... tells Gino he has never heard of the Wocket ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4
... carried a gene that increases your risk for Alzheimer,s disease? And ... damage not when you,re old but when you,re young? ... strong genetic component to the development of late-onset Alzheimer,s. In 1993, ... a quarter of us that triples the risk for getting ...
... ARLINGTON, VA (May 3, 2011) Cancer studies from ... unveiled at the American Association of Pharmaceutical Scientists, (AAPS) ... May 16 -Wednesday, May 18 at the Hilton San ... Oral Vaccine for Cervical Cancer Cervical cancer ...
... overcome their evolutionary legacies to become much better at ... of energy that can power vehicles in the near ... solar scientists has found. A U.S. Department of ... 18 scientists to compare the efficiency of plants and ...
Cached Biology News:Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits 2Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits 3AAPS national biotechnology conference to highlight breakthrough cancer treatments 2NREL's multi-junction solar cells teach scientists how to turn plants into powerhouses 2NREL's multi-junction solar cells teach scientists how to turn plants into powerhouses 3
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... 2014 Deep Knowledge Ventures last ... on ‘Commercialising Longevity Research’ and welcomed a host ... London Bioscience Innovation Center for the event, organised ... Analytics Ltd. The meeting highlighted the need for ... for age-related disease, as well as the crucial ...
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... June 21, 2011 Ikaria, Inc., a critical care ... to address the significant needs of critically ill patients ... its Chairman and CEO, Daniel Tasse, will present at ... International Convention on Tuesday, June 28, 2011 from 2:30 ...
... 2011 Merisel, Inc. (OTC: MSEL) operating under ... , a leading provider of visual communications and brand imaging ... last night at the 9th Annual American Business Awards Ceremony, ... its commitment to delivering solid results, despite prevailing economic turbulence. ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ... targeting the extracellular matrix , today announced ... programs at the American Diabetes Association (ADA) ... 2011 at the San Diego Convention Center. ...
Cached Biology Technology:Ikaria® To Present at 2011 BIO Business Forum and International Convention 2Merisel, Inc. Wins Business Turnaround of the Year at the 2011 American Business Awards 2Merisel, Inc. Wins Business Turnaround of the Year at the 2011 American Business Awards 3Merisel, Inc. Wins Business Turnaround of the Year at the 2011 American Business Awards 4Merisel, Inc. Wins Business Turnaround of the Year at the 2011 American Business Awards 5Halozyme Therapeutics to Present Data on its Ultrafast Insulin Programs at the Upcoming American Diabetes Association 71st Scientific Sessions 2Halozyme Therapeutics to Present Data on its Ultrafast Insulin Programs at the Upcoming American Diabetes Association 71st Scientific Sessions 3
Molecular Biological Resources offers bulk quantities of existing protein products. Please see the Chimerx divisions website for existing products and contact lloconne@molbiores.com for pricing....
... scales with RS232 ports and sends that data ... type the weight into the program, BalanceTalk can ... use parser extracts required data , Add date/time ... Collect data at timed intervals , Keyboard macros ...
Peptide-affinity Purified Polyclonal Antibody to Prolactin Releasing Hormone Receptor (GPR10)...
... BalanceTalk XL provides balance data collection and automation ... Complete integration with Microsoft Excel , Pre-configured ... analyzers , New balances can be added and ... data from multiple balances into one spreadsheet ...
Biology Products: