Navigation Links
Berkeley Lab researchers illuminate laminin's role in cancer formation
Date:3/7/2011

Laminin, long thought to be only a structural support protein in the microenvironment of breast and other epithelial tissues, is "famous" for its cross-like shape.

However, laminin is far more than just a support player with a "pretty face." Two studies led by one of the world's foremost breast cancer scientists have shown how laminin plays a central role in the development of breast cancer, the second most common cancer and second leading cause of cancer death among women in the United States. In one study it was shown how laminin influences the genetic information inside a cell's nucleus. In the other study it was shown how destruction of laminin can play a detrimental role in the early stages of tumor development.

Mina Bissell holds the title of "Distinguished Scientist" with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab). She herself is famous for having discovered the critical role in breast cancer development played by the extracellular matrix (ECM), the network of fibrous and globular proteins surrounding a breast cell. Her "dynamic reciprocity" theory holds that the fate of cells whether they stay healthy or become cancerous hinges on the chemical signals exchanged between the ECM and a cell's nucleus. In these latest studies, Bissell and her collaborators focused on laminin and its connections with two other proteins actin, a cytoplasmic protein that has been linked to nuclear activities; and MMP9, an enzyme that is secreted outside the cells and is known to break down ECM constituents.

Laminin and Cell Quiescence

"Quiescence" is the process by which a biological cell stops growing or dividing. This is the opposite of a cancerous state, in which cell growth and division is often unchecked. Signals from laminin-111, an ECM protein that helps the cell and its ECM stick together, have been linked to cell quiescence but the mechanism was unknown. Bissell and postdocto
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Berkeley Lab to build DOE advanced biofuels user facility
2. Berkeley scientists find new way to get physical in the fight against cancer
3. Berkeley Lab researchers participate in Homeland Security study of subway airflow
4. Berkeley Lab lends expertise to India to promote energy efficiency
5. Nanyang Technological University and University of California, Berkeley pursue research alliance
6. Researchers discover new shapes of microcompartments
7. Researchers find possible new treatment strategies for pancreatic cancer
8. Scripps oceanography researchers discover arctic blooms occurring earlier
9. Nature study: Jefferson researchers unravel proteins elusive role in embryo and disease development
10. York U researchers uncovering how ovarian cancer resists chemotherapy
11. Researchers predict age of T cells to improve cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Berkeley Lab researchers illuminate laminin's role in cancer formation
(Date:6/16/2015)... 2015 /CNW Telbec/ - handyem Inc. and FlowMetric ... incorporation of handyem,s HPC-150 portable flow cytometer within ... This unprecedented model of mobile laboratory platform is ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue ...
(Date:6/15/2015)... According to a new market research report ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... Natural Language Processing Market is expected to grow to ... forecast period 2015-2020. Browse 65 market ...   through 155 P ages and in-depth TOC ...
(Date:6/11/2015)... Daon, a global leader in mobile ... Mobile Authentication Platform v4.0 has been FIDO Certified™.  ... industry consortium launched in 2013 to revolutionize online ... In order to receive certification, a company,s products ... tests that measure compliance and ensure interoperability among ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... that the Human Genome Project missed 99 percent of the ... genes belonging to the vast communities of bacteria that normally ... grant from the W.M. Keck Foundation to researchers at the ... a study to develop new approaches for isolating, sequencing and ...
... from the Departments,of Chemical and Environmental Engineering, Mechanical ... to discover a way to,utilize Quantum Dot ... of a protein at the growing,pollen tube tip. ... another,protein (chemocyanin) in guiding sperm-laden pollen tubes to ...
... ago, Massachusetts General Hospital (MGH) researchers discovered that ... stem cells that could regenerate the insulin-producing islets ... finding, members of the,same team now report that ... believed to be present only during the embryonic,development ...
Cached Biology News:W.M. Keck Foundation funds study of friendly microbes 2W.M. Keck Foundation funds study of friendly microbes 3Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants 2Spleen may be source of versatile stem cells 2Spleen may be source of versatile stem cells 3
(Date:7/2/2015)... Calif. (PRWEB) , ... July 02, 2015 , ... Sleepless ... improve an individual’s quality of sleep, launched its Indiegogo campaign on June 23. Sound ... Luzi's voice command technology makes it effortless to use, while the integration of the ...
(Date:7/1/2015)... PARIS , July 1, 2015 ... key developer of biotech crops, today announce a ... generations of insect control traits. "Growers ... the realities of advancing insect resistance. We are ... insect control technology with Genective,s capability in developing ...
(Date:7/1/2015)... India , July 1, 2015  Strand Life ... generation sequencing technology to empower cancer care, today announced ... chief executive officer. In his expanded role as now ... strategy, business expansion and worldwide operations effective immediately.  Dr. ... chairman and CEO since its founding in 2000, will ...
(Date:7/1/2015)... CHANDLER, Ariz. , July 1, 2015 ... announced it has earned three Gold, three Silver, and ... Business Awards gala held in Chicago ... recognized as the premier business awards program in the ... and recognizes our company,s strength in developing leaders, cultivating ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3AgBiome and Genective collaborate to create novel insect-resistant crops 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3
... DALLAS, Sept. 18 More than 60 physicians credentialed,to ... Hospital of,Dallas were honored by D Magazine at its ... is one of the premier specialty surgical,hospitals in the ... so many of,our physicians again included in this prestigious ...
... Bioreactor (S.U.B.) To Its Portfolio Of Assets ... ... Laureate Pharma, Inc., a,full-service biopharmaceutical development and protein production company,today announced that ... Acquisition of a 250L and a,1000L S.U.B. will give Laureate greater flexibility ...
... will use their extensive field sales expertise and established relationships ... engineered ceramic manufacturing design, development and testing expertise. , ... ... -- JD Technologies, LLC, an effective field sales company and ...
Cached Biology Technology:Annual List of 'Best Doctors in Dallas' Showcases Texas Institute for Surgery Physicians 2Laureate Pharma to Add More Manufacturing Capacity 2JD Technologies, LLC Selected by FCT Ingenieurkeramik GmbH to Represent Their High Performance Ceramic Expertise In the United States 2JD Technologies, LLC Selected by FCT Ingenieurkeramik GmbH to Represent Their High Performance Ceramic Expertise In the United States 3
... As research demands continue to grow, the ... spectral information has become necessary, especially when ... colors. The innovative C1si Confocal Microscope System ... and spectral capability not available in conventional ...
... is described by end-users to be "a ... fundamentals of light microscopy and electronic imaging. ... it does not require much space and ... lab environment. The DM-BA300 combines Motic's own ...
... Drive for individual and parallel agitation control ... of DASGIP vessels, featuring range of stirring ... to 16 overhead drives can be operated ... fedbatch-pro® and cellferm-pro® for microbiology and cell ...
... Science LAS-3000 imaging system combines new ... user interface, providing significantly improved system ... modularities. The system is especially dedicated ... standard system for Western blotting applications.,Fuiji's ...
Biology Products: