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Beneficial bacteria may help ward off infection
Date:7/20/2012

vival and this effect increased when L. reuteri were producing reuterin.

Another interesting detail uncovered in the study is that the effects of reuterin on Salmonella's infectious capacity are increased in the presence of host cells, suggesting that some type of synergistic protection occurs during epithelial infection, potentially involving the combined activity of reuterin and host cell gene-related responses.

Prolonged exposure (of 24 hours or more) to the reuterin-containing supernatant solutions caused a loss of viability in host cells, though shorter exposure times did not appear to adversely affect them. Importantly, the introduction of L. reuteri strains in vivo have been safely carried out in infants and even immuno-compromised adults, indicating that other cell types, host factors or the complex gut microbiota in vivo could counteract the observed cytotoxic effects of reuterin in vitro.

While the authors stress that much work remains, particularly in terms of understanding reuterin's role in the context of a complex gut microbiome, the results are encouraging and suggest a new avenue for fighting Salmonella infection, through the process of glycerol conversion to reuterin by L. reuteri.


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Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert  

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