Navigation Links
Ben-Gurion University Alzheimer's researcher demonstrates specific immune response to vaccine
Date:9/21/2009

BEER-SHEVA, September, 21 2009 A researcher who is working on a vaccine for Alzheimer's disease (AD) has demonstrated that it is possible to test and measure specific immune responses in mice carrying human genes and to anticipate the immune response in Alzheimer's patients. This continuing research at Ben-Gurion University of the Negev could one day lead to specific Alzheimer's vaccines that reduce plaque, neuronal damage and inflammation associated with the disease.

Amyloid beta-peptide accumulates in the brain of AD patients where it appears to promote neuronal damage. In the new article published in the Journal of Immunology, BGU researcher Dr. Alon Monsonego determined that introducing A-beta into the brain triggers a natural immune response which can be detected in humans.

Importantly, the research team showed that the specificity and magnitude of this body response to A-beta depends on certain key genes of the immune system, which are highly polymorphic in the population (this means that except for identical twins, almost each of us has a different combination of genes termed "HLA alleles").

Furthermore, this research took an unusual approach combining humans and humanized mouse models. "We began with characterizing the genes in humans in a collaboration with the laboratories of Dr. Weiner and Dr. Selkoe at Harvard, then did the same study in mice using a mouse model of multiple sclerosis witht the laboratory of Dr. Altmann- Imperial College School of Medicine, UK," Monsonego explains. "We then generated a humanized mouse model of AD, with a specific gene that was present in approximately 30 percent of our study group (HLA DR15 allele). Conceivably, those people that have this gene could receive the same vaccine which will teach a person's immune system to better fight the disease."

Monsonego continues, "As in other mouse models of the disease, we show that with aging A-beta aggregates accumulate in bra
'/>"/>

Contact: Andrew Lavin
alc@alavin.com
516-353-2505
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ben-Gurion University of the Negev technology being developed for use in Jordan desalination plant
2. Ben-Gurion U. developing new computer techniques to analyze historic Hebrew and Arabic documents
3. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
4. Ben-Gurion U. researchers reveal connection between cancer and human evolution
5. Ben-Gurion University research and technology used in new solar energy farm
6. Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience
7. Ben-Gurion University engineers develop technique to help combat nuclear proliferation
8. Ben-Gurion University of the Negev researchers develop new reversible, green window technology
9. Ben-Gurion University of the Negev to host
10. Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia
11. Environmental peace treaty between Israel and Palestinians unveiled at Ben-Gurion University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
(Date:11/10/2014)... began appearing on U.S. store shelves in early 2010, ... since. The small packets can be tossed into a ... liquid or powder. The convenience, though, has come with ... researchers at Nationwide Children,s Hospital found that from 2012 ... 17,230 children younger than 6 years of age swallowing, ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
... suggests that a blood clot-dissolving medication that is administered ... may help to reduce the risk of amputation following ... issue of Archives of Surgery, one of the JAMA/Archives ... for the past 25 years, according to background information ...
... nanoparticle made in a laboratory at the University of ... device for treating glaucoma, an eye disease that can ... “The nanoparticle can safely get past the blood-brain barrier ... said Sudipta Seal, an engineering professor with appointments in ...
... of infections and other diseases of the brain is ... from reaching the brain. Grantees of the National Institute ... Institutes of Health, have now shown that a short ... strip of therapeutic material into the brain via intravenous ...
Cached Biology News:Clot-dissolving agent may be beneficial in treatment of severe frostbite 2UCF nanoparticle offers promise for treating glaucoma 2Blood-brain barrier breached by new therapeutic strategy 2
(Date:11/24/2014)... One of the most extensive, widely cited digital ... now available to high school and junior college students and ... international society for optics and photonics , announced today that ... Library available to high schools for free and two-year ... to all areas of life in today’s world,” said SPIE ...
(Date:11/24/2014)... The new video, “ Save Time ... how to reduce the number of instruments on ... design can be complicated, requiring multiple chemical measurements ... and deposition. Dedicated single and dual channel transmitters ... space. Additionally, installing and maintaining each transmitter, its ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Apiscent ... supplier of fine chemical ingredients to the global ... launch of its new website, Apiscent.com. , The ... Apiscent Labs, clean design, easy navigation, rotating images ... Apiscent Labs stand out. , The ...
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
Breaking Biology Technology:SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2
... introduced the world to tiny robots demonstrating soccer ... competition designed to advance microroboticsthe field devoted to ... dimensions are measured in micrometers (millionths of a ... Technology (NIST), in collaboration with IEEE, is inviting ...
... While other states jockeyed for position on Business ... its ranking as best in the Midwest and No. ... bioscience industry . , (Logo: ... bioscience ranking is in part due to updated estimates ...
... A faster tool for cell programming and a new way ... prizes of the 2009 Collegiate Inventors Competition, a program of ... Fund, the non-profit foundation of the global health care company ... Harris Wang, who invented a new way of cell ...
Cached Biology Technology:Is your microrobot up for the (NIST) challenge? 2Ohio Bioscience Industry Leads Midwest, Among Best in Nation as Investment Destination 2Winners Announced in 2009 Collegiate Inventors Competition(R) 2Winners Announced in 2009 Collegiate Inventors Competition(R) 3Winners Announced in 2009 Collegiate Inventors Competition(R) 4Winners Announced in 2009 Collegiate Inventors Competition(R) 5Winners Announced in 2009 Collegiate Inventors Competition(R) 6Winners Announced in 2009 Collegiate Inventors Competition(R) 7
Request Info...
Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, Serine Protease Regulators...
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble...
... Since the Flp-In System creates ... produce equivalent levels of the protein ... demonstrated in Figure 3. In this ... transferase (CAT) was subcloned into pcDNA5/FRT ...
Biology Products: