Navigation Links
Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
Date:4/10/2012

BEER-SHEVA, ISRAEL, April 10, 2012 BGN Technologies, the technology transfer company for Ben-Gurion University of the Negev (BGU), has signed a licensing agreement for its V-Smart drug delivery technology with Lauren Sciences LLC, a privately held biotechnology company in New York.

Lauren Sciences will develop the technology as a platform for treating a variety of diseases that affect the central nervous system (CNS), including Parkinson's, Alzheimer's, Amyotrophic Lateral Sclerosis (ALS), as well as brain malignancies.

V-Smart technology is based on nanovesicles made of proprietary building blocks that provide high stability, large encapsulation capacity, targeting to specific cells and tissues, a controlled release mechanism, and passage through biological barriers, including the blood brain barrier (BBB). The V-SmartTM technology pinpoints where the drug will be released in the brain, increasing efficacy and reducing adverse effects.

It was developed by BGU researchers Dr. Sarina Grinberg of the Department of Chemistry, Dr. Charles Linder of the Department of Biotechnology and Department of Clinical Biochemistry Prof. Eliahu Heldman, who also serves as Lauren Science's chief scientific officer. Lauren Sciences will continue to conduct development activities at BGU.

"Our pre-clinical studies demonstrate that novel, nano-sized V-Smart vesicles encapsulate small molecules, peptides, proteins and nucleic acids, cross the BBB and release their encapsulated contents in the brain," said Prof. Heldman. "Our goal is to target, protect and restore dopaminergic neurons (nerve cells) in the brain that deteriorate during the course of Parkinson's disease. The success of this project should improve Parkinson's patients' lives."

The BBB is permeable for small molecules; however, an active drug delivery transport system is required for other substances. There is currently an unmet need and a great medical challenge for a safe, effective and reliable drug delivery transport system to deliver viable chemotherapeutic agents to the brain of patients with brain cancer or other CNS related clinical states.

The V-Smart platform is protected by several worldwide patents filed by BGN Technologies. Lauren Sciences was recently awarded a grant from the Michael J. Fox Foundation to develop a V-Smart therapeutic for Parkinson's disease.


'/>"/>

Contact: Andrew Lavin
andrewlavin@alavin.com
516-944-4486
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Related biology news :

1. Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia
2. Ben-Gurion University of the Negev to host
3. Ben-Gurion University of the Negev researchers develop new reversible, green window technology
4. Ben-Gurion University engineers develop technique to help combat nuclear proliferation
5. Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience
6. Ben-Gurion University research and technology used in new solar energy farm
7. Ben-Gurion U. researchers reveal connection between cancer and human evolution
8. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
9. Ben-Gurion U. developing new computer techniques to analyze historic Hebrew and Arabic documents
10. Ben-Gurion University of the Negev technology being developed for use in Jordan desalination plant
11. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/11/2020)... SEABROOK, N.H. (PRWEB) , ... June 09, 2020 , ... ... integrator of custom industrial automation and IT solutions for the life sciences industry, is ... President of Business Development working out of the company’s Seabrook, New Hampshire office. ...
(Date:6/5/2020)... ... 04, 2020 , ... Greffex, a pioneering vaccine and gene therapy company based ... understands the need for a global perspective to make an impact in a post ... will serve as an independent, director of the company. , “The Greffex board is ...
(Date:5/28/2020)... ... May 27, 2020 , ... CrucialTrak, a global designer and manufacturer ... Critical Environments Group (CEG) to market and sell its complete line of biometric ... IT environment infrastructure optimization solutions . , Brett Mason, CrucialTrak’s Director of ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a ... 2020, despite many obstacles created as a result of COVID-19. As a provider ... partnered medical practices and medical manufacturers by expanding access to device offerings, technology ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/23/2020)... Fla. (PRWEB) , ... June 23, 2020 , ... ... enabled solutions in complex indoor environments, announced today that Derek Fournier has been ... role of Chairman of the Board, effective immediately. , “DeCurtis Corporation has ...
(Date:6/19/2020)... , ... June 18, 2020 , ... The Vitaspace ... goal is to join forces to radically prolong life and find a way (medicine ... aging period. This project was supported by various scientists from all over the world, ...
Breaking Biology Technology: