Navigation Links
Beer's bitter compounds could help brew new medicines
Date:1/29/2013

Researchers employing a century-old observational technique have determined the precise configuration of humulones, substances derived from hops that give beer its distinctive flavor.

That might not sound like a big deal to the average brewmaster, but the findings overturn results reported in scientific literature in the last 40 years and could lead to new pharmaceuticals to treat diabetes, some types of cancer and other maladies.

"Now that we have the right results, what happens to the bitter hops in the beer-brewing process makes a lot more sense," said Werner Kaminsky, a University of Washington research associate professor of chemistry.

Kaminsky is the lead author of a paper describing the findings, published this month in the journal Angewandte Chemie International Edition.

There is documentation that beer and its bittering acids, in moderation, have beneficial effects on diabetes, some forms of cancer, inflammation and perhaps even weight loss.

Kaminsky used a process called X-ray crystallography to figure out the exact structure of those acids, humulone molecules and some of their derivatives, produced from hops in the brewing process. That structure is important to researchers looking for ways to incorporate those substances, and their health effects, into new pharmaceuticals.

Humulone molecules are rearranged during the brewing process to contain a ring with five carbon atoms instead of six. At the end of the process two side groups are formed that can be configured in four different ways both groups can be above the ring or below, or they can be on opposite sides.

Which of the forms the molecule takes determines its "handedness," Kaminsky said, and that is important for understanding how a particular humulone will react with another substance. If they are paired correctly, they will fit together like a nut and bolt.

If paired incorrectly, they might not fit to
'/>"/>

Contact: Vince Stricherz
vinces@uw.edu
206-543-2580
University of Washington
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bitter tastes quickly turn milk chocolate fans sour
2. Hearty organisms discovered in bitter-cold Antarctic brine
3. Biosensor illuminates compounds to aid fight against TB
4. New screening technique yields elusive compounds to block immune-regulating enzyme
5. Sulphur and iron compounds common in old shipwrecks
6. Heparin-like compounds inhibit breast cancer metastasis to bone
7. Nuisance seaweed found to produce compounds with biomedical potential
8. New drug-screening method yields long-sought anti-HIV compounds
9. Nonstoichiometric Compounds V - An ECI Conference Series
10. Poisoning from industrial compounds can cause similar effects to ALS
11. University of Albertas designer compounds inhibit prion infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Beer's bitter compounds could help brew new medicines
(Date:10/14/2014)... millions of years since T. rex took ... University scientists is breathing life back into dinosaurs using ... The research has important implications for how dinosaurs used ... the sense of smell and cool their brains. ... doctoral student Jason Bourke, lead author of the new ...
(Date:10/14/2014)... a new kind of stem cell that can become either ... vessels, according to a study published today in the journal ... cell type contradicts current theory on how organs arise from ... origins of, and future treatment for, liver cancer., Thanks to ... complex being made up of more than 200 cell types. ...
(Date:10/14/2014)... led by researchers at the University of Massachusetts ... Miller School of Medicine (UMMSM) have identified what ... (manic depressive) disorder, a breakthrough that could lead ... as well as depression and other related mood ... week in Nature Molecular Psychiatry , show ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... which could offer hope for sufferers of Alzheimer's disease, is ... Engineering Centre (MEC). , Alzheimer's disease is the most common ... cases of dementia. Dementia affects one person in 20 over ... the age of 80. , Certain species of daffodil, which ...
... future drug designAs part of a $4.88 million grant ... the University of Rochester Medical Center will join a ... of a living cell. By wiring diagram, researchers mean ... and their function, but also of the interplay between ...
... at The University of Texas at Austin protects and ... and other more expensive antibodies. , The high-affinity antibody, ... its deadly toxins in animal tests. If future tests ... late-stage anthrax infection, even for an anthrax strain that ...
Cached Biology News:New study to explore cellular circuitry 2New study to explore cellular circuitry 3New antibody shows promise as cure for anthrax 2New antibody shows promise as cure for anthrax 3
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
(Date:10/20/2014)... , A major pan-European survey into the ... care has revealed changing trends in many important GI ... of healthcare services across the continent. The results of ... (UEG), have been announced today and led to calls ... of GI disorders across Europe ...
(Date:10/20/2014)... Earle Martin , Chief ... that Ellen Teplitzky, an experienced attorney specializing in ... industry, has joined the firm as Director of ... practice. NDA Partners provides legal services, including ... to top law firms and their clients in ...
(Date:10/19/2014)... Oct. 19, 2014 NextCODE Health, which enables clinicians ... in real time, today announced the launch of its new ... , at the American Society of Human Genetics (ASHG) annual ... more, sign up and apply for free beta access, visit ... and benefits can be viewed here . ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... are Urged to Vote their YELLOW proxy, FOR the ... Independent Directors to the Biovail Board,TORONTO, May 15 /PRNewswire/ ... Biovail Corporation (NYSE: BVF ) (TSX:BVF) continues to ... this dispute Mr. Melnyk. , The requisition was simply ...
... May 15 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, today reported financial and operational ... the first quarter of 2009, PharmAthene recognized revenues of ... period of 2008. Revenues for the most recent ...
... CITY, Shandong, China, May 15 /PRNewswire-Asia-FirstCall/ -- China,Biologic ... or the,Company,), one of the leading plasma-based pharmaceutical ... announced that the Company,s,management will present at the ... in New York, NY on May 18, 2009 ...
Cached Biology Technology:The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 2The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 3The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 4The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 5The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 6The Concerned Shareholders of Biovail Say Biovail Has Misled Shareholders 7PharmAthene Reports First Quarter 2009 Financial and Operational Results 2PharmAthene Reports First Quarter 2009 Financial and Operational Results 3PharmAthene Reports First Quarter 2009 Financial and Operational Results 4PharmAthene Reports First Quarter 2009 Financial and Operational Results 5PharmAthene Reports First Quarter 2009 Financial and Operational Results 6PharmAthene Reports First Quarter 2009 Financial and Operational Results 7China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 2China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 3China Biologic Products to Present at CCG IR's China Rising Conference and Oppenheimer's China Dragon Call Conference in New York 4
...
... Signet offers the most comprehensive, cost-effective ... We have incorporated unprecedented quality into ... This includes proven detection chemistries and ... the TechMate protocol. It also includes ...
... Resistant (X/R) Red System consists of ... Activator and X/R Red Buffer. The ... phosphatase to produce red staining that ... Contains:, , Buffer, 100 mL , ...
Human Cell Line Slides...
Biology Products: