Navigation Links
Beehive extract shows potential as prostate cancer treatment
Date:5/3/2012

d have taken hundreds of Westerns, hundreds of technicians, and a very large amount of money for antibodies."

The micro-western array results allowed researchers to quickly build a new model of CAPE's cellular effects, significantly expanding on previous work that studied the compound's mechanisms. Treatment with CAPE at the concentrations that arrested cancer cell growth suppressed the activity of proteins in the p70S6 kinase and Akt pathways, which are important sensors of sufficient nutrition that can trigger cell proliferation.

"It appears that CAPE basically stops the ability of prostate cancer cells to sense that there's nutrition available," Jones said. "They stop all of the molecular signatures that would suggest that nutrition exists, and the cells no longer have that proliferative response to nutrition."

The ability of CAPE to freeze cancer cell proliferation could make it a promising co-treatment alongside chemotherapies intended to kill tumor cells. Jones cautioned that clinical trials would be necessary before CAPE could be proven effective and safe for this purpose in humans. But the CAPE experiments offer a precedent to unlock the biological mechanisms of other natural remedies as well, perhaps allowing these compounds to cross over to the clinic.

"A typical problem in bringing some of these herbal remedies into the clinic is that nobody knows how they act, nobody knows the mechanism, and therefore researchers are typically very hesitant to add them to any pharmaceutical treatment strategy," Jones said. "Now we'll actually be able to systematically demonstrate the parts of cell physiology that are affected by these compounds."


'/>"/>

Contact: Rob Mitchum
robert.mitchum@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. 2 books explore the history and delights of honey, bees and beehives
2. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
3. Pomegranate extract stimulates uterine contractions
4. Papaya extract thwarts growth of cancer cells in lab tests
5. Seaweed extract may hold promise for non-Hodgkins lymphoma treatment
6. Chokeberry extract found to regulate weight gain, blood glucose, and inflammation in rats
7. Researchers study cinnamon extracts
8. Microchip patented which separates and extracts tumor cells in the blood
9. Extracting cellular engines may aid in understanding mitochondrial diseases
10. Green chemistry extraction method developed for hot capsicum fruit
11. Dietary yeast extracts tested as alternative to antibiotics in poultry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... Efficient and Sustainable Global Logistics Operations) is aiming to ... efficiency of intermodal loading systems and the boosting of ... European organisations with experience in the logistics sector and ... 17,000,000 and a duration of three and a half ... the semantic components and ontologies shared by the users, ...
(Date:5/17/2013)... Societies for Experimental Biology (FASEB) released a new ... trends highlighting the devastating impact of sequestration on the ... follows a May 15th Senate Appropriations Committee hearing featuring ... the $1.6 billion cut the agency sustained in FY ... on the scientific community." , According to data ...
(Date:5/16/2013)... Bethesda, MD (May 17, 2013) Illustrating a ... the American Gastroenterological Association (AGA) Research Foundation ... Future Student Research Fellowship Award recipients. Supported by ... Kidney Diseases (NIDDK), this new award helps underrepresented ... digestive disease and nutrition research. , "By establishing ...
Breaking Biology News(10 mins):New logistics services that will cut energy consumption and CO2 emissions 2Underrepresented minority students receive fellowships in digestive disease and nutrition research 2
... MAOne of the big, unsolved problems in explaining how ... could the basic biochemicalssuch as amino acids and nucleotideshave ... to carry out their formation? In a paper ... Bulletin, scientists propose that a third type of ...
... This release is available in Spanish . ... of fungi on peanuts, can be used on corn as ... (USDA) scientists who helped develop it. After extensive ... the U.S. Environmental Protection Agency (EPA) for use on corn, ...
... Researchers at Yale School of Medicine have developed a ... of eventually treating people with the disorder. Hemophilia A, a ... by a variety of mutations in the factor VIII gene. ... the study aimed to provide a better understanding of hemophilia ...
Cached Biology News:Transition metal catalysts could be key to origin of life, scientists report 2Transition metal catalysts could be key to origin of life, scientists report 3Yale develops new animal model for hemophilia A 2
(Date:5/17/2013)... Calif. , May 17, 2013  Cellular ... has achieved 50% enrollment of the total projected ... evaluate the safety and preliminary efficacy of the ... therapy for Knee Osteoarthritis (KOA). To date the ... reported. The Phase I open label ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 Men’s skin is ... La-roche Posay ) and has been known to react ... some men may be far from puberty, other acne causing ... pores, causing breakouts, and threatening skin with unsightly acne scars. ... from Men’s Health on how to reduce and ...
(Date:5/17/2013)... 2013 IAC Industries wants to share with ... laboratory needing to set up and furnish a research lab ... facility within a year’s time. How does a company make ... is temporary? What is efficient and cost-effective? , The ... IAC Industries. The planners at DisperSol determined that the concept ...
(Date:5/16/2013)... 2013 Oven Industries, Inc. has been ... and temperature sensors since 1964. Expertly designed, the ... control system applications. As one of the ... generic, control loop feedback system, which helps minimize errors. ... adjust a systematic process, using a control element, like ...
Breaking Biology Technology:Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis 2Adult Acne Treatment, Probiotic Action Shares New Insight on Why Men’s Skin Scars from Acne and How to Prevent It 2New Downloadable Success Story: “How To Outfit a Dynamic Lab in Flux” 2New PID Temperature Controllers Announced by Oven Industries Inc. 2
... , , , , , from rat lung, recombinant, , , ... , Catalog Number, Pack Size, ... 2000 units, , , 3335402, ... , , , , , , Package Inserts/Product , Instructions, ...
... carry-over prevention Cat. No. 1 585 541 , (1 Kit = 50 reactions) , ... , , The PCR Core Kit PLUS supplies all basic reagents to perform ... and appropriate primers. The kit contains: , , ... Taq DNA Polymerase , PCR Nucleotide MixPLUS , ...
... Polymerase for two-step RT-PCR amplification of up to 4 kb targets , ... , , , , , ... C. therm. Polymerase provided by Roche Applied Science is the recombinant , ... hydrogenoformans, expressed in E. coli. The recombinant enzyme lacks the , ...
Cached Biology Technology:PCR Core KitPLUS 2C. therm. Polymerase for Reverse Transcription in Two-Step RT-PCR 2
RABBIT ANTI NEOPTERIN...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
... Dog Serum-Mixed Breed • Dog serum is collected ... one year of age Available Anticoagulants: ... (Na) N-06: K2EDTA N-08: ... N-03: Alsevers N-05: ACD ...
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
Biology Products: