Navigation Links
Be happy: Your genes may thank you for it
Date:7/29/2013

A good state of mind that is, your happiness affects your genes, scientists say. In the first study of its kind, researchers from UCLA's Cousins Center for Psychoneuroimmunology and the University of North Carolina examined how positive psychology impacts human gene expression.

What they found is that different types of happiness have surprisingly different effects on the human genome.

People who have high levels of what is known as eudaimonic well-being the kind of happiness that comes from having a deep sense of purpose and meaning in life (think Mother Teresa) showed very favorable gene-expression profiles in their immune cells. They had low levels of inflammatory gene expression and strong expression of antiviral and antibody genes.

However, people who had relatively high levels of hedonic well-being the type of happiness that comes from consummatory self-gratification (think most celebrities) actually showed just the opposite. They had an adverse expression profile involving high inflammation and low antiviral and antibody gene expression.

The report appears in the current online edition of the journal Proceedings of the National Academy of Sciences.

For the last 10 years, Steven Cole, a UCLA professor of medicine and a member of the UCLA Cousins Center, and his colleagues, including first author Barbara L. Fredrickson at the University of North Carolina, have been examining how the human genome responds to stress, misery, fear and all kinds of negative psychology.

In this study, though, the researchers asked how the human genome might respond to positive psychology. Is it just the opposite of stress and misery, or does positive well-being activate a different kind of gene expression program?

The researchers examined the biological implications of both hedonic and eudaimonic well-being through the lens of the human genome, a system of some 21,000 genes that has evolved fundamentally to help humans survive and be well.

Previous studies had found that circulating immune cells show a systematic shift in baseline gene-expression profiles during extended periods of stress, threat or uncertainty. Known as conserved transcriptional response to adversity, or CTRA, this shift is characterized by an increased expression of genes involved in inflammation and a decreased expression of genes involved in antiviral responses.

This response, Cole noted, likely evolved to help the immune system counter the changing patterns of microbial threat that were ancestrally associated with changing socio-environmental conditions; these threats included bacterial infection from wounds caused by social conflict and an increased risk of viral infection associated with social contact.

"But in contemporary society and our very different environment, chronic activation by social or symbolic threats can promote inflammation and cause cardiovascular, neurodegenerative and other diseases and can impair resistance to viral infections," said Cole, the senior author of the research.

In the present study, the researchers drew blood samples from 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounding negative psychological and behavioral factors. The team used the CTRA gene-expression profile to map the potentially distinct biological effects of hedonic and eudaimonic well-being.

And while those with eudaimonic well-being showed favorable gene-expression profiles in their immune cells and those with hedonic well-being showed an adverse gene-expression profile, "people with high levels of hedonic well-being didn't feel any worse than those with high levels of eudaimonic well-being," Cole said. "Both seemed to have the same high levels of positive emotion. However, their genomes were responding very differently even though their emotional states were similarly positive.

"What this study tells us is that doing good and feeling good have very different effects on the human genome, even though they generate similar levels of positive emotion," he said. "Apparently, the human genome is much more sensitive to different ways of achieving happiness than are conscious minds."


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related biology news :

1. Controlling genes with light
2. Susceptibility genes for cerebral infarction or hemorrhage in the Han in Hunan, China
3. Cigarette smoke impacts genes linked to health of heart and lungs
4. Insecticide causes changes in honeybee genes, research finds
5. Symptoms of Prader-Willi syndrome associated with interference in circadian, metabolic genes
6. Its all in the genes -- including the tracking device
7. The genomes 3-D structure shapes how genes are expressed
8. 4 genes indentified that influence levels of bad cholesterol
9. Study: MicroRNA cooperation mutes breast cancer oncogenes
10. AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
11. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016  The American College of ... Trade Show Executive Magazine as one of the fastest-growing ... May 25-27 at the Bellagio in Las Vegas ... the highest percentage of growth in each of the following ... exhibiting companies and number of attendees. The 2015 ACMG Annual ...
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: