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Baylor, DNAnexus, Amazon Web Services collaboration enables largest-ever cloud-based analysis of genomic data
Date:10/25/2013

search and clinical contexts, was an integral part of the project. The pipeline identifies mutations from genomic data, setting the stage for determining the significance of these mutations as a cause of serious disease.

Led by Dr. Eric Boerwinkle, professor and director of the Human Genetics Center at The University of Texas Health Science Center at Houston and associate director of the Human Genome Sequencing Center at BCM, the CHARGE project involves more than 300 researchers across five institutions around the world. The cloud-based analysis makes it possible for the large group to have access to an expansive network of data over a server that is HIPAA certified to not compromise patient privacy.

"The collaboration between the CHARGE consortium and the Human Genome Sequencing Center is leading to discovery of those genes contributing to risk of the most important diseases plaguing the U.S. population across all age groups," said Boerwinkle. "Ultimately, these discoveries forge a path toward novel therapeutics and diagnostics. The use of cloud computing and collaboration with DNAnexus is allowing us to achieve our goals faster and in a more cost-effective manner."(Boerwinkle will give an updated presentation November 15 at the Cold Spring Harbor Laboratory's Personal Genomes & Pharmacogenomics Meeting.)

"Having access to this much data was unique," said Reid. "Many institutions do not have the local compute resources and infrastructure to support large scale analysis projects like this one, so we were lucky to come together with DNAnexus and Amazon Web Services to make this project possible."

The project required approximately 2.4 million core-hours of computational time, generating 440 TB (terabytes) of results and nearly a petabyte of storage that took place over a four-week period.

By comparison, the

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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