Navigation Links
Baumann lab identifies elusive telomere RNA subunit in single cell model
Date:12/27/2007

The Stowers Institutes Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition.

Chromosomes shorten with every cell division. In stem cells and in cancer cells, this shortening is compensated by telomerase, an enzyme that adds short repeat sequences to the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most cancer cells, the enzyme is considered a promising target for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further intensified interest in understanding telomerase and its regulation.

The RNA subunit of telomerase is of particular interest as it represents one of the two core components of telomerase and provides the template for the short repeats that are added to the ends of chromosomes. The Baumann Lab is working to understand how telomerase is assembled, how it is recruited to chromosome ends, and how its activity is regulated. These efforts may shed light on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a variety of diseases including cancer and coronary heart disease.

Telomerase RNA has been studied in a variety of simple model organisms, but telomere maintenance turned out to be quite different in these species compared to human cells. Recently, the Baumann Lab used a biochemical approach to identify and clone the RNA subunit of telomerase in Schizosaccharomyces pombe, or fission yeast.

The identification of the fission yeast equivalent of the telomerase RNA gene provides us with a critical tool to study telomerase in a genetically tractable, single-cell organism with a telomere maintenance machinery that shares many features with human cells, explained Peter Baumann, Ph.D., Assistant
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Understanding hypertension in African Americans proves elusive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... in which animals can be found, concern mounts over ... increased range for a host mean new territory for ... team of UC Santa Barbara scientists, including parasitologists Ryan ... the Journal of Biogeography , Hechinger, Kuris and ... happen: Hosts may actually lose their parasites when the ...
(Date:7/9/2014)... selection for traits that are attractive to the opposite ... to mate, the tail of male peacocks being an ... Riverside have now found that sexual selection and "placentation" ... Describing the life histories of more than 150 species ... that species with placentas tend to have males that ...
(Date:7/9/2014)... crucial piece of the puzzle behind nature,s ability ... could help advance the development of artificial photosynthesis ... provided by an international collaboration of scientists led ... (Berkeley Lab) and the SLAC National Accelerator Laboratory. ... Source (LCLS), the world,s most powerful x-ray laser, ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3
... that some bird species in the desert southwest are less ... through their habitat. In fact, the Baylor researchers say that ... that is formed after a fire is positive for the ... bird species in the Chihuahuan Desert scaled Quail, Loggerhead ...
... 2011. Knowing how trees grow and how they age ... a warmer climate, for instance, and other changes. Little is ... with tree growth. "Although much research has been done on ... they increase in size," says research ecologist Frederick (Rick) Meinzer, ...
... form of malignancy in adult Caucasian populations, with more than ... Lifestyle risk factors but , The ... the aging structure of Western populations, and as a result ... sun exposure, which is a key risk factor for NMSC, ...
Cached Biology News:Study finds some desert birds less affected by wildfires and climate change 2Some cutaneous HPV types may be involved in non-melanoma skin cancer development 2
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... Media Resulted in Increased Yield and Quality of Insulin-Producing Islet ... ... BOTHELL, Wash., Oct. 24 BioLife Solutions,Inc. (OTC Bulletin Board: BLFS), ... products for,cells, tissues, and organs, today announced that MicroIslet Inc. (OTC,Bulletin ...
... CPC of America, Inc.,(OTC Bulletin Board: CPCF), ... in endovascular procedures, announced today that it has,entered ... to the,agreement, BC Tech will manufacture the MedClose(TM) ... device that may be,used with a biological sealant ...
... for Patients with Lung, ... Prostate, Liver and Pancreatic Cancer, SUNNYVALE, Calif., Oct. 24 ... the field of radiosurgery,announced today that treatments of extracranial tumors ... the fiscal year ending June 30, 2008. Specifically, during this,time, ...
Cached Biology Technology:BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes 2BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes 3BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes 4CPC of America Announces Agreement with BC Tech for Manufacture of MedClose(TM) Vascular Closure System 2CPC of America Announces Agreement with BC Tech for Manufacture of MedClose(TM) Vascular Closure System 3CyberKnife System Achieves 38 Percent Growth in Extracranial Treatments During Fiscal Year 2008 2CyberKnife System Achieves 38 Percent Growth in Extracranial Treatments During Fiscal Year 2008 3CyberKnife System Achieves 38 Percent Growth in Extracranial Treatments During Fiscal Year 2008 4
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
Biology Products: