Navigation Links
Baumann lab identifies elusive telomere RNA subunit in single cell model
Date:12/27/2007

The Stowers Institutes Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition.

Chromosomes shorten with every cell division. In stem cells and in cancer cells, this shortening is compensated by telomerase, an enzyme that adds short repeat sequences to the ends of chromosomes to replenish lost DNA. As telomerase is required for the continued growth of most cancer cells, the enzyme is considered a promising target for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further intensified interest in understanding telomerase and its regulation.

The RNA subunit of telomerase is of particular interest as it represents one of the two core components of telomerase and provides the template for the short repeats that are added to the ends of chromosomes. The Baumann Lab is working to understand how telomerase is assembled, how it is recruited to chromosome ends, and how its activity is regulated. These efforts may shed light on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a variety of diseases including cancer and coronary heart disease.

Telomerase RNA has been studied in a variety of simple model organisms, but telomere maintenance turned out to be quite different in these species compared to human cells. Recently, the Baumann Lab used a biochemical approach to identify and clone the RNA subunit of telomerase in Schizosaccharomyces pombe, or fission yeast.

The identification of the fission yeast equivalent of the telomerase RNA gene provides us with a critical tool to study telomerase in a genetically tractable, single-cell organism with a telomere maintenance machinery that shares many features with human cells, explained Peter Baumann, Ph.D., Assistant Investigator and senior author on the paper. We and others had been studying telomerase activity, recruitment, and regulation for several years but the fact that the RNA subunit was unknown in our fission yeast model system severely limited our ability to make progress.

Now that the missing component of the model system has been identified, the Baumann Labs structural and functional studies are expected to progress rapidly. The lab is now turning its attention to how and where telomerase is assembled from its components in the cell and what processing it must undergo to become active.


'/>"/>
Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Understanding hypertension in African Americans proves elusive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... 2017 , ... When James Sherley, was notified earlier this year that his company Asymmetrex ... 2017 by The Silicon Review , he was not surprised as others might be. ... but this recognition by Silicon Valley was particularly meaningful. Our selection by ...
(Date:5/16/2017)... ... 16, 2017 , ... Cynvenio Biosystems, Inc. a ... Cancer blood test. Leveraging a highly-sensitive next-generation sequencing panel of 11 genes known ... and accurately identify tumor-related genetic mutations that can be treated with targeted therapies. ...
(Date:5/15/2017)... (PRWEB) , ... May 15, 2017 , ... Tunnell ... in a presentation of “The Key Role of Specifications in Process Validation,” at the ... Philadelphia . The event will bring together leaders from the pharmaceutical and biotech industries ...
(Date:5/15/2017)... , May 15, 2017  IBM (NYSE: IBM ... can stretch double-stranded DNA molecules with the potential ... This technology complements the IBM Research,s ... such as exosomes and which may also contain ... uses an array of diamond shaped micropillars 1 ...
Breaking Biology Technology: