Navigation Links
Battling diabetes with beta cells
Date:9/2/2008

Affecting eight percent of America's population, diabetes can lead to blindness, kidney failure, strokes and heart disease. Thanks to Tel Aviv University researchers, a new cure based on advances in cell therapy may be within reach.

Prof. Shimon Efrat from TAU's Sackler Faculty of Medicine, whose research group is among world leaders in beta cell expansion, has developed a way to cultivate cells derived from insulin-producing beta cells from human tissue in the laboratory. It may be possible to implant these new healthy cells into patients with type 1 diabetes.

If successful, this method, which artificially replicates the insulin cells people need, could ensure that fewer people will die while waiting for a life-saving pancreas and kidney. Prof. Efrat's research paves the way for new and alternative forms of treatment in cases in which organ transplantation is not an option. And one day, the procedure may be as simple as a blood transfusion.

The Multiplication Effect

Type 1 diabetes, the most severe form of the condition, emerges as a chronic condition in childhood or early adulthood, when the body's immune system stops working properly and destroys the beta cells in the pancreas. Beta cells are needed to produce insulin, and a shortage of insulin inhibits the breakdown of food into energy. By the time a diagnosis is made, most beta cells are destroyed beyond repair. Injections of insulin can ease the symptoms, but some sufferers from the disease eventually require extreme measures, such as organ transplants, to stay alive.

"The shortage of organ donors makes the development of new cell sources for cell therapy critical," says Prof. Efrat. "Using beta cell expansion, we are able to grow a massive reserve of healthy cells that may be made to produce enough insulin to restore the function of the destroyed cells."

In contrast to previous research, which failed to multiply mouse beta cells in culture, Prof. Efrat's work has increased the number of human beta cells successfully. "In theory, cells from one donor can be multiplied thousands of times," says Prof. Efrat, explaining that the next hurdle will be to "convince" these beta cells to produce insulin in the human body. Another major hurdle he faces is to get a body's immune system to accept these new cells when transplanted. Human clinical trials, Prof. Efrat cautions, may not begin for another five years or more.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related biology news :

1. Battling virus disease of watermelon with bottlegourds
2. New research suggests diabetes transmitted from parents to children
3. Compound that helps rice grow reduces nerve, vascular damage from diabetes
4. Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
5. Moores UCSD Cancer Center study links vitamin D, type 1 diabetes
6. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
7. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
8. People with diabetes may have all natural citrus supplement
9. Stem cell breakthrough offers diabetes hope
10. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
11. Major collaboration uncovers surprising new genetic clues to diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Battling diabetes with beta cells
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: