Navigation Links
Battling brittle bones... with broccoli and spinach?
Date:12/11/2012

Troy, N.Y. A new study from engineering researchers at Rensselaer Polytechnic Institute shows, for the first time, how the little-understood protein osteocalcin plays a significant role in the strength of our bones. The findings could lead to new strategies and therapeutics for fighting osteoporosis and lowering the risk of bone fracture.

Funded by the U.S. National Institutes of Health, the study details how fractures in healthy bones begin with the creation of incredibly tiny holes, each measuring only about 500 atoms in diameter, within the bone's mineral structure. In the case of a slip, trip, or fall, the force of the impact on a bone physically deforms a pair of joined proteins, osteopontin and osteocalcin, and results in the formation of nanoscale holes. These holes, called dilatational bands, function as a natural defense mechanism, and help to prevent further damage to the surrounding bone. However, if the force of the impact is too greator if the bone is lacking osteopontin, osteocalcin, or boththe bone will crack and fracture.

The multi-university study, led by Deepak Vashishth, head of the Department of Biomedical Engineering at Rensselaer, is the first to give evidence of fracture at the level of bone's nanostructure. Partnering with Rensselaer on the study were Villanova University, the Hospital for Special Surgery in New York, and Yale University.

"This study is important because it implicates, for the first time, the role of osteocalcin in giving bone the ability to resist fracture," Vashishth said. "Since osteocalcin is always the point of fracture, we believe that strengthening it could lead to a strengthening of the overall bone."

Long known but little understood, the protein osteocalin has been produced by and present in animal bones since before the dawn of humanity. Recently, abnormalities in ostoecalcin production have been associated with type 2 diabetes as well as problems in reproductive health.
'/>"/>

Contact: Michael Mullaney
mullam@rpi.edu
518-276-6161
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Invasive brittle star species hits Atlantic Ocean
2. 5-limbed brittle stars move bilaterally, like people
3. The power of broccoli, in a capsule
4. Safer spinach? Scientists technique dramatically reduces E. coli numbers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Battling brittle bones... with broccoli and spinach?
(Date:10/16/2014)... Cancer constantly wages war on the human body. ... a stalemate. In pancreatic cancer, this stalemate—known as ... becoming aggressively malignant, a phenomena that is poorly ... in the laboratory of Salvatore Torquato, a Professor ... the conditions surrounding tumor dormancy and the switch ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
(Date:10/16/2014)... (October 16, 2014) – Post-menopausal women experienced improvements ... hormone levels or genital bleeding, after 12 weeks ... investigational fermented soy germ-based nutritional supplement previously shown ... a new peer-reviewed pilot study reported in a ... annual scientific meeting. , "These data documented ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... humans to plants to the lowliest bacterium use molecules ... an organism,s development, and still others are used to ... California Institute of Technology have now found a rare ... Caenorhabditis elegans that serves a dual purpose, working ...
... L-1 Identity,Solutions, Inc., (NYSE: ID ), ... hold a supplemental conference call for Q&A with ... ended June 30,2008 financial results at 2:00 p.m. ... the initial 11:00 a.m. (ET) call,today were unable ...
... healthy, nutritious plant. The research paper, published with ... Carolina, appeared in the early online edition of the ... week of July 21. "There,s a lot of attention ... principal investigator on the study and one of the authors ...
Cached Biology News:Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes 2Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes 3L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today 2Dartmouth researchers identify an important gene for a healthy, nutritious plant 2
(Date:10/25/2014)... A new way to produce engineered skin not ... grafting technologies, it also speeds up the healing process, ... the October issue of STEM CELLS Translational Medicine, could ... result from severe burns and chronic wounds. , A ... These wounds heal by contraction, with epithelization (the process ...
(Date:10/25/2014)... LONDON , October 24, 2014 ... CytRx Corporation (NASDAQ: CYTR ), Vertex Pharmaceuticals ... (NASDAQ: ALXN ), Peregrine Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... on Thursday, October 23, 2014, ended on a positive ...
(Date:10/22/2014)... and BOSTON , Oct. 22, ... a leading global specialty pharmaceutical company, and Rhythm, a ... an exclusive option to acquire Rhythm,s wholly owned subsidiary, ... peptide ghrelin agonist, for the treatment of diabetic gastroparesis ... has completed a successful Phase 2 trial of relamorelin ...
(Date:10/22/2014)... WriteResult, LLC – a premier ... working with a team of researchers from Yale University’s ... Farming Collaborative to provide electronic questionnaire data collection through ... which started in May, aims to evaluate the impact ... exposure to and participation in urban agriculture to impact ...
Breaking Biology Technology:New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... is next weekend's BarCamp Madison , but his long-view ... state's first national technology unconference. , ,Wisconsin has the honor ... 23-26 on the Jefferson County fairgrounds. , ,Rheingans, director of ... to draw 5,000 technologists to the 90-acre site, which is ...
... and the Vancouver Island Health Authority (VIHA) ... authority would purchase 48 new ultrasound systems. , ,The ... new clinical workflow and administrative processes. , ,Jac ... result in more precise diagnosis and faster exams, and reduce ...
... of articles on developing start-up companies in the technology or ... , , Madison, Wis. - Your ... workers. As discussed in the previous article, you generally must ... and Medicare taxes, and unemployment taxes on wages ...
Cached Biology Technology:Wisconsin to host technology BarCamp USA 2Wisconsin to host technology BarCamp USA 3Early Stage 7, Part I: Just what is an employee? 2Early Stage 7, Part I: Just what is an employee? 3Early Stage 7, Part I: Just what is an employee? 4Early Stage 7, Part I: Just what is an employee? 5