Navigation Links
Bat plant could give some cancers a devil of a time
Date:11/22/2011

In a new study published this month in the Journal of the American Chemical Society, researchers with The University of Texas Health Science Center at San Antonio have pinpointed the cancer-fighting potential in the bat plant, or Tacca chantrieri.

Susan Mooberry, Ph.D., leader of the Experimental Development Therapeutics Program at the Cancer Therapy & Research Center and a professor of pharmacology at the UT Health Science Center, has been working to isolate substances in the plant, looking for a plant-derived cancer drug with the potential of Taxol.

Taxol, the first microtubule stabilizer derived from the Yew family, has been an effective chemotherapy drug, but patients eventually develop problems with resistance over time and toxicity at higher doses. Researchers have long been seeking alternatives.

"We've been working with these for years with some good results, but never with the potency of Taxol," said Dr. Mooberry, lead author of the study. "Now we have that potency, and we also show for the first time the taccalonolides' cellular binding site."

Microtubules are structures in the cells that act as conveyer belts. They help maintain cell shape and help guide chromosones in cell division to ensure that every new cell, including every new cancer cell, gets a full complement of genetic material. When microtubules are stabilized -- essentially held still so they can't do their jobs -- this disrupts numerous cellular processes, and the cell can die.

The taccalonolides stabilize microtubules in cancer cells, but they do not attack healthy cells, Dr. Mooberry said. "We've run normal prostate cells and normal breast cells through these tests, and they don't die. The taccalonolides selectively kill cancer cells."

Until now, how they did this was unknown. The isolation of these highly potent taccalonolides for the first time by Dr. Mooberry's team shows how they interact directly with microtubules.


'/>"/>
Contact: Elizabeth Allen
allenea@uthscsa.edu
210-450-2020
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related biology news :

1. Formula discovered for longer plant life
2. Commercial aquatic plants offer cost-effective method for treating wastewater
3. Structures of important plant viruses determined
4. Research about plant viruses could lead to new ways to improve crop yields
5. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
6. Reproducing early and often is the key to rapid evolution in plants
7. MSU scientists find new gene that helps plants beat the heat
8. Diversity of plant-eating fishes may be key to recovery of coral reefs
9. Researchers design artificial cells that could power medical implants
10. Plant-eating predator to fight superweed is not magic bullet
11. When under attack, plants can signal microbial friends for help
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 14, 2016 "Increase in ... biometrics market" The mobile biometrics market is expected to ... 49.33 billion by 2022, at a CAGR of 29.3% ... factors such as the growing demand for smart devices, ... transactions. "Software component is expected to grow ...
(Date:12/8/2016)... Dec. 8, 2016  Singulex, Inc., the leader in ... entered into a license and supply agreement with Thermo ... agreement provides Singulex access to Thermo Scientific BRAHMS PCT ... is used to diagnose systemic bacterial infection and ... to aid in assessing the risk of critically ...
(Date:12/7/2016)... , Dec. 7, 2016   Avanade ... successful Formula One teams in history, exploit biometric data ... stop performance and maintain the competitive edge against their ... 2016. Avanade has worked with Williams ... range of biometric data (heart rate, breathing rate, temperature ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... January 20, 2017 Stock-Callers.com explores ... have influenced the most recent performances of select equities. ... RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... TBPH ), and Sage Therapeutics Inc. (NASDAQ: ... Grand View Research, global Biotech market size is expected to reach $604.40 ...
(Date:1/20/2017)... 2017 http://www.Financialbuzz.com - ... leading causes of death worldwide. There were 8.2 million ... cancer related deaths increased gradually over time, the death ... of various cancers continues to drive demand of biological ... Global Market Insights, Inc. cancer biological therapy market size was ...
(Date:1/19/2017)... 2017 Research and Markets has announced the ... Cancer Type, Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" ... ... market is projected to reach $15,737 million by 2022 from $6,521 ... 2022. Omic technologies segment accounted for more than ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
Breaking Biology Technology: