Navigation Links
Barrow scientists uncover clues on inflammation in central nervous system
Date:10/21/2010

(PHOENIX, AZ) -- Scientists at Barrow Neurological Institute have recently made discoveries about a type of cell that may limit inflammation in the central nervous system (CNS) a finding that could have important implications in the treatment of brain disorders such as multiple sclerosis. The research, led by Barrow's Fu-Dong Shi, MD, PhD, was published in the August 2010 issue of The Journal of Experimental Medicine, and simultaneously highlighted in Nature.

Dr. Shi directs the Neuroimmunology Laboratory and Flow Cytometry Core Facility at Barrow. One of his research interests is natural killer (NK) cells, a type of immune cell that destroys tissue that has been infected by pathogens and malignant cells. While recent research has shed more light on the role of NK cells in other parts of the body, Dr. Shi's research is unveiling important discoveries about how NK cells work in the CNS.

In multiple sclerosis, the body's immune system attacks myelin, a protective sheath surrounding nerve cells in the brain and spinal cord. By studying a pre-clinical model of multiple sclerosis, the Barrow research revealed that enriching an affected area with NK cells improved disease symptoms, while blocking NK cells to the CNS made symptoms worse. The research indicates that NK cells especially those that originate in the CNS, as opposed to NK cells from peripheral organs play a critical role in controlling the magnitude of CNS inflammation and immune response.

"These studies provide novel insight into the biology of NK cells and might lead to the design of NK cell-based approaches for intervention in inflammatory and autoimmune disorders of the central nervous system," says Dr. Shi. "Our findings have important implications for understanding the efficacy of some drugs currently used in CNS diseases such as multiple sclerosis."


'/>"/>

Contact: Lynne Reaves
lynne.reaves@chw.edu
602-406-4734
St. Joseph's Hospital and Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. Barrow scientist leads insula research
2. Barrow scientist receives $450K MDA grant
3. New era of pain drugs advanced by Barrow researcher
4. Barrow researcher finds natural hydrogel helps heal spinal cord
5. Barrow scientist awarded $400,000 grant to study cell associated with intuition and autism
6. Barrow scientists solve 200-year-old scientific debate involving visual illusions
7. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
8. Frontal lobe of the brain is key to automatic responses to various stimuli, say scientists
9. Illinois scientists promote soy by currying favor with Indian taste buds
10. NIH-funded scientists sequence genomes of lyme disease bacteria
11. Scientists closer to grasping how the brains hearing center spurs responses to sound
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract ... to improve patient outcomes and quality of life, will now be offering its ... attributed to new regulatory requirements for all new drug products, including the finalization ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., a ... Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas ... practices and how Proscia improves lab economics and realizes an increase in diagnostic ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
Breaking Biology Technology: