Navigation Links
Barrow scientists identify new stem cell activity in human brain
Date:9/28/2011

Researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center have identified a new pathway of stem cell activity in the brain that represents potential targets of brain injuries affecting newborns. The recent study, which raises new questions of how the brain evolves, is published in the current issue of Nature, one of the world's most cited scientific journals.

Nader Sanai, MD, director of Barrow's Brain Tumor Research Center, led this study, which is the first developmental study of human neural stem cells in a region of the brain called the subventricular zone, the tissue structure in which brain stem cells reside. Also participating in the study were researchers from University of California San Francisco and the University of Valencia in Spain.

The findings revealed that there is a pathway of young migrating neurons targeting the prefrontal cortex of the human brain in the first few months of life. After the first year of life, the subventricular zone of the brain slows down, tapering production of new brain cells by the time a child is 18-months and then to nearly zero by age two. This revelation settles conflicting prior reports that suggested that human neural stem cell cells remain highly active into adulthood.

"In the first few months of life, we identified streams of newly-generated cells from the subventricular portion of the brain moving toward the frontal cortex," says Dr. Sanai. "The existence of this new pathway, which has no known counterpart in all other studied vertebrates, raises questions about the mechanics of how the human brain develops and has evolved."

Researchers believe this study holds important implications for the understanding of neonatal brain diseases that can cause death or devastating, life-long brain damage. These conditions include germinal matrix hemorrhages, the most common type of brain hemorrhage that occurs in infants; and perinatal hypoxic ischaemic injuries, exposure to low oxygen and decreased blood flow that can lead to diseases such as cerebral palsy and seizure disorders.

"The first year of human life has a window of vulnerability, as well as tremendous opportunity, for the brain," says Dr. Sanai. "It's a period of incredible growth, organization, and flexibility, as fresh neural connections are created, broken, and remade. A better understanding of how things can go wrong in that critical period could ultimately improve the chances that things will go right."


'/>"/>

Contact: Carmelle Malkovich
cmalkovich@chw.edu
602-406-3319
St. Joseph's Hospital and Medical Center
Source:Eurekalert

Related biology news :

1. Barrow scientists uncover clues on inflammation in central nervous system
2. Barrow scientist leads insula research
3. Barrow scientist receives $450K MDA grant
4. New era of pain drugs advanced by Barrow researcher
5. Barrow researcher finds natural hydrogel helps heal spinal cord
6. Barrow scientist awarded $400,000 grant to study cell associated with intuition and autism
7. Barrow scientists solve 200-year-old scientific debate involving visual illusions
8. President to honor high achieving, early career NOAA scientists
9. Scientists model the pathways of pain-blocking meds
10. Scientists lay out plans for efficient harvesting of solar energy
11. Scientists probe Indian Ocean for clues to worldwide weather patterns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/11/2016)... 2016 --> ... "Image Recognition Market by Technology (Pattern Recognition), by Component ... Deployment Type (On-Premises and Cloud), by Industry Vertical and ... MarketsandMarkets, the global market is expected to grow from ... by 2020, at a CAGR of 19.1%. ...
(Date:3/9/2016)... GARDENS, Fla. , March 9, 2016 /PRNewswire/ ... management authentication and enrollment solutions, today announced the ... DigitalPersona ® Altus multi-factor authentication platform. ... and InfoSec managers to step-up security where it,s ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... , May 26, 2016 Despite ... see value in this space. Today,s pre-market research on ActiveWallSt.com ... Radius Health Inc. (NASDAQ: RDUS ), Cerus Corp. ... ARWR ), and Five Prime Therapeutics Inc. (NASDAQ: ... technical briefings at: http://www.activewallst.com/ ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot for ... one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm ... and intimate team-building experience. , Each event kicks off with an olive oil and ...
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics Association ... the National Coordinator for Health IT (ONC) outlining a measurement approach to interoperability ... available when and where it was needed. The organization of health informatics professionals ...
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven ... Administration (FDA) has granted the company’s orphan drug designation request covering BHV-4157 for ... designation granted by the FDA. , Spinocerebellar ataxia is a rare, debilitating ...
Breaking Biology Technology: