Navigation Links
Baffling blood problem explained
Date:3/20/2013

In the early 1950's, a 66-year-old woman, sick with colon cancer, received a blood transfusion. Then, unexpectedly, she suffered a severe rejection of the transfused blood. Reporting on her case, the French medical journal Revue D'Hmatologie identified her as, simply, "Patient Vel."

After a previous transfusion, it turns out, Mrs. Vel had developed a potent antibody against some unknown molecule found on the red blood cells of most people in the worldbut not found on her own red blood cells.

But what was this molecule? Nobody could find it. A blood mystery began, and, from her case, a new blood type, "Vel-negative," was described in 1952.

Soon it was discovered that Mrs. Vel was not alone. Though rare, it is estimated now that over 200,000 people in Europe and a similar number in North America are Vel-negative, about 1 in 2,500.

For these people, successive blood transfusions could easily turn to kidney failure and death. So, for sixty years, doctors and researchers have huntedunsuccessfullyfor the underlying cause of this blood type.

But now a team of scientists from the University of Vermont and France has found the missing moleculea tiny protein called SMIM1and the mystery is solved.

Reporting in the journal EMBO Molecular Medicine, UVM's Bryan Ballif, Lionel Arnaud of the French National Institute of Blood Transfusion, and their colleagues explain how they uncovered the biochemical and genetic basis of Vel-negative blood.

"Our findings promise to provide immediate assistance to health-care professionals should they encounter this rare but vexing blood type," says Ballif.

The pre-publication results were presented online, March 18, 2013, and the finalized report will be published, as an open-access article, in the next edition of the journal.

(Last year, Ballif and Arnaud identified the proteins responsible for two other rare blood types, Junior and Langeris, moving t
'/>"/>

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Third-party blood stem cell transplantation as a factor to impact on poor graft function
2. White blood cells found to play key role in controlling red blood cell levels
3. Prenatal exposure to pesticide DDT linked to adult high blood pressure
4. Temp-controlled nanopores may allow detailed blood analysis
5. Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
6. Stressed proteins can cause blood clots for hours
7. Study uncovers enzymes double life, critical role in cancer blood supply
8. Manchester patients take part in pioneering heart attack blood test trial
9. Blood vessels sniff gut microbes to regulate blood pressure
10. Childhood blood lead levels rise and fall with exposure to airborne dust in urban areas
11. Blood is thicker than water -- and blood plasma is, too
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Baffling blood problem explained
(Date:8/24/2015)... 2015  Based on its recent analysis of the biometric ... African Biometrics Company of the Year Award. DERMALOG is the ... in Africa . It has particularly gained ... implemented one of the largest biometric mass applications in the ... Central Bank of Nigeria with its ...
(Date:8/20/2015)... OXFORD, CT ., Aug. 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... wallet, announces it has joined The Smart Card Alliance ... the Smart Card Alliance and the Smart Card Alliance ... and visibility to industry peers and thought leaders promoting ...
(Date:8/18/2015)... DUBLIN , Aug. 17, 2015 ... the addition of the "Global Biometric Authentication ... Application - Estimation & Forecast, 2015-2020" report ... biometric authentication and identification systems market is expected ... from 2015 to 2020 and generate over $25 ...
Breaking Biology News(10 mins):Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... when cosmetics, shampoos, skin creams, and other personal care ... to plant-derived extracts and other natural ingredients government ... the silicone-based ingredients long used in these products. That,s ... of Chemical & Engineering News (C&EN), ACS, weekly newsmagazine. ...
... Weizmann Institute scientists have added another piece to the obesity ... active in a small part of the brain contributes to ... . Prof. Ari Elson and his team in ... with female mice that were genetically engineered to lack this ...
... A group of 12 biology educators at ... argues in the May issue of BioScience ... and teaching of ecology conducted at these institutions. ... dedicated to continental-scale observations, argues that better coordination ...
Cached Biology News:Weizmann Institute scientists discover: A protein that contributes to obesity 2
(Date:8/27/2015)... ... August 27, 2015 , ... ... venture capital funds, investment firms and animal health companies to hear from animal ... $160 million. Several have also received licensing agreements or distribution contracts. This ...
(Date:8/27/2015)... TORONTO , Aug. 27, 2015 /PRNewswire/ - ... Securities Exchange: PBT.U), and Biohaven Pharmaceutical Holding Company ... in a Phase I study of BHV-0223, a ... application (IND) regarding BHV-0223 and recently obtained clearance ... to proceed with human testing. Portage holds 54% ...
(Date:8/27/2015)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced its ... Biorem,s complete second quarter financial statements and MD&A have been filed ... earnings per shareThree-months ended , Six -months endedJune 30 , June ... , 2014 Revenue , 4,709 , 2,459 ... 1,656 , 56 , 3,188 ...
(Date:8/27/2015)... ... , ... Inc. Magazine released its annual list of the 5,000 fastest-growing privately ... for the three years through 2014. Being named to the Inc. 5000 list designates ... country. , “We are thrilled to make the Inc. 5000 list for 2015,” ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3
... University of California, San Diego electrical engineers are building a ... solar energy without using fossil fuels and harvest it for ... the team said nanowires, which are made from abundant natural ... way to deliver hydrogen fuel on a mass scale. ...
... March 7, 2012 Neuralstem, Inc. (NYSE Amex: ... cells in the cervical (upper back) region of the spine ... trial of its spinal cord neural stem cells in amyotrophic ... also the first woman to be treated in the trial. ...
...   Camelot Healthcare Training Institute , a post-secondary nursing ... has been acquired by Medtech College.  Camelot now joins ... College once appropriate state approvals have been obtained. ... campuses offering accredited training in nursing and a number ...
Cached Biology Technology:Nanotrees harvest the sun's energy to turn water into hydrogen fuel 2Fourteenth Patient Dosed in Neuralstem ALS Stem Cell Trial 2Fourteenth Patient Dosed in Neuralstem ALS Stem Cell Trial 3Camelot Healthcare Training Institute Acquired by Medtech 2Camelot Healthcare Training Institute Acquired by Medtech 3