Navigation Links
Bad proteins branch out
Date:11/25/2013

HOUSTON (Nov. 25, 2013) A method by Rice University researchers to model the way proteins fold and sometimes misfold has revealed branching behavior that may have implications for Alzheimer's and other aggregation diseases.

Results from the research will appear online this week in the Proceedings of the National Academy of Sciences.

In an earlier study of the muscle protein titin, Rice chemist Peter Wolynes and his colleagues analyzed the likelihood of misfolding in proteins, in which domains discrete sections of a protein with independent folding characteristics become entangled with like sequences on nearby chains. They found the resulting molecular complexes called "dimers" were often unable to perform their functions and could become part of amyloid fibers.

This time, Wolynes and his co-authors, Rice postdoctoral researcher Weihua Zheng and graduate student Nicholas Schafer, modeled constructs containing two, three or four identical titin domains. They discovered that rather than creating the linear connections others had studied in detail, these proteins aggregated by branching; the proteins created structures that cross-linked with neighboring proteins and formed gel-like networks that resemble those that imbue spider silk with its remarkable flexibility and strength.

"We're asking with this investigation, What happens after that first sticky contact forms?" Wolynes said. "What happens if we add more sticky molecules? Does it continue to build up further structure out of that first contact?

"It turned out this protein we've been investigating has two amyloidogenic segments that allow for branch structures. That was a surprise," he said.

The researchers used their AWSEM (Associative memory, Water-mediated Structure and Energy Model) program to analyze how computer models of muscle proteins interact with each other, particularly in various temperatures that determine when a protein is
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. 2-way traffic enable proteins to get where needed, avoid disease
2. New look identifies crucial clumping of diabetes-causing proteins
3. Newly identified proteins make promising targets for blocking graft-vs.-host disease
4. Proteins in one of the worlds main biodiesel plants have been mapped -- and it does not look good
5. Researchers capture images of open channel that moves proteins across cell membranes
6. The yin and yang in the life of proteins
7. Zinc, proteins, and an essential cellular balancing act
8. Erratic proteins: New insights into a transport mechanism
9. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
10. Scientists decipher cellular roadmap of disease-related proteins
11. Toronto team IDs proteins key in stem cell production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bad proteins branch out
(Date:10/15/2014)... 44th Rosenstiel Award for Distinguished Work in Biomedical Science ... mechanisms of genomic instability and its implications for the ... alumnus to win the Rosenstiel Award; the first, Rod ... is the Charles A. Janeway Professor of Pediatrics and ... investigator at the Howard Hughes Medical Institute at Boston ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
(Date:10/14/2014)... questions is how to produce enough food to feed ... and Agriculture Organization of the United Nations predicts that ... years to feed a growing global population, and plants ... food production. Plants—grains, cereals, fruits, vegetables, and more—feed ... research must tap into our knowledge of how plants ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Northern Arizona University and the National Center for Ecological ... circuit theory to predict gene flow across landscapes. Their ... the best spots for wildlife corridors, which are crucial ... similarities between circuit theory and ecological connectivity, said Brad ...
... and Post-It Notes Three things that started out as obscure ... will the next idea to stick with modern society look ... a humble lizard, according to a University of Calgary biologist ... to virtually any surface, including glass., Unlike most creatures, geckos ...
... University of the Basque Country (UPV/EHU), an in vitro culture ... reproduce the gene regulation that is expressed in these cancer ... patients. This in vitro culture model provides a simple tool ... factors regulating this expression, as well as a simple form ...
Cached Biology News:Model connects circuit theory to wildlife corridors 2Sticky questions tackled in gecko research 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 3
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... PARK, Calif. , Oct. 20, 2014 /PRNewswire/ ... today that the Company has signed a Notice ... of Regenerative Medicine (CIRM), effective October 1, 2014.  ... Clinical Development payments and the release of additional ... million CIRM grant award for clinical development of ...
(Date:10/20/2014)... 20, 2014  GenVec, Inc. (NASDAQ: GNVC ) ... Ph.D., from its board of directors effective on October 24, ... and served as its chairman from June 2006 to November ... and Corporate Governance and Audit Committees of the board.  ... decade of dedicated service to GenVec, and its stockholders," said ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... Syngenta today announced that it has acquired Georgia-based ... protection technology to the company,s portfolio. Circle One Global ... a toxin that can develop in crops such as corn ... , "The acquisition of this technology adds an important ...
... ... Biotechnology Laboratory, and support US and European power supplies. , ... Williamstown, NJ (PRWEB) June 11, 2009 -- ... box. The CS230000 and CS230001 both are new Biotechnology kits from A-WIT Technologies. Choose ...
... ... financial services offerings to further meet the needs of emerging businesses. ... on Demand - NSS partners with their clients acting as an outsourced ... Solutions team equips its clients with multiple game plans; a blue print ...
Cached Biology Technology:Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 2Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 3A-WIT Technologies Releases World's First Low Cost C Stamp(TM) Based Biotechnology Laboratory in a Box 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 3
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
...
...
... the 9, 10, 12, and 13 positions. It ... for the quantification of 9(S)-HODE by GC- or ... of linoleic acid in both plants and animals. ... an esterified component of membrane phospholipids and in ...
Biology Products: