Navigation Links
Bad proteins branch out
Date:11/25/2013

HOUSTON (Nov. 25, 2013) A method by Rice University researchers to model the way proteins fold and sometimes misfold has revealed branching behavior that may have implications for Alzheimer's and other aggregation diseases.

Results from the research will appear online this week in the Proceedings of the National Academy of Sciences.

In an earlier study of the muscle protein titin, Rice chemist Peter Wolynes and his colleagues analyzed the likelihood of misfolding in proteins, in which domains discrete sections of a protein with independent folding characteristics become entangled with like sequences on nearby chains. They found the resulting molecular complexes called "dimers" were often unable to perform their functions and could become part of amyloid fibers.

This time, Wolynes and his co-authors, Rice postdoctoral researcher Weihua Zheng and graduate student Nicholas Schafer, modeled constructs containing two, three or four identical titin domains. They discovered that rather than creating the linear connections others had studied in detail, these proteins aggregated by branching; the proteins created structures that cross-linked with neighboring proteins and formed gel-like networks that resemble those that imbue spider silk with its remarkable flexibility and strength.

"We're asking with this investigation, What happens after that first sticky contact forms?" Wolynes said. "What happens if we add more sticky molecules? Does it continue to build up further structure out of that first contact?

"It turned out this protein we've been investigating has two amyloidogenic segments that allow for branch structures. That was a surprise," he said.

The researchers used their AWSEM (Associative memory, Water-mediated Structure and Energy Model) program to analyze how computer models of muscle proteins interact with each other, particularly in various temperatures that determine when a protein is
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. 2-way traffic enable proteins to get where needed, avoid disease
2. New look identifies crucial clumping of diabetes-causing proteins
3. Newly identified proteins make promising targets for blocking graft-vs.-host disease
4. Proteins in one of the worlds main biodiesel plants have been mapped -- and it does not look good
5. Researchers capture images of open channel that moves proteins across cell membranes
6. The yin and yang in the life of proteins
7. Zinc, proteins, and an essential cellular balancing act
8. Erratic proteins: New insights into a transport mechanism
9. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
10. Scientists decipher cellular roadmap of disease-related proteins
11. Toronto team IDs proteins key in stem cell production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bad proteins branch out
(Date:7/31/2014)... Hibiscus flowers- they are an iconic symbol of ... in the landscape. Some, like Hawaii,s State Flower- ... Only a relatively few botanists and Hawaiian conservation ... and intriguing related group of plants known as ... Brother of Hibiscus species are in fact highly ...
(Date:7/31/2014)... NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication company ... and consumers wanting to learn more about its  ... on-air today, July 31 st . ... featured in a segment of NewsWatch, a weekly ... the History Channel, FYI Network today. ...
(Date:7/30/2014)... uses reversible epigenetic processes to regulate its genes, and ... a picture of the genome regulation taking place in ... Genome Biology and illustrates how the truffle ... genes,. The authors say this may shed light on ... Black truffles (Tuber melanosporum), also known as Prigord truffles, ...
Breaking Biology News(10 mins):Brother of Hibiscus is found alive and well on Maui 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3How black truffles deal with the jumpers in their genome 2
... tiny luminescent particles made of semiconductors, hold promise ... doctors were to use them in humans, quantum ... and possible toxicity. Scientists at Emory University ... a way around those limitations by exploiting a ...
... Calif.) The apparent success of a case in which ... marrow transplant comes as no surprise to Gerhard Bauer, a ... more than 10 years on a similar cure for AIDS ... patient with stem cells that have been engineered to resist ...
... discovered that management efforts intended to assist migrations of ... fish populations. Juveniles that are transported downstream on boats ... breeding grounds, reducing their survivorship and altering adaptations in ... place for over three decades to improve the survival ...
Cached Biology News:'Strained' quantum dots show new optical properties 2UC Davis researchers exploring gene therapy to fight AIDS 2UC Davis researchers exploring gene therapy to fight AIDS 3Transporting juvenile salmon hinders adult migration 2Transporting juvenile salmon hinders adult migration 3
(Date:7/31/2014)... SHENZHEN, China , July 31, 2014 ... an Irys™System by BGI , the ... enable comprehensive exploration of human structural variation (SV) and ... interest, including those where no reference exists. In addition, ... methods for multiplexing on the Irys System, enabling significantly ...
(Date:7/31/2014)... Toronto, Canada (PRWEB) July 31, 2014 ... with some of the first transcriptome-wide analyses appearing ... a standard assay for RNA measurement. In the ... high throughput, more specific, work with smaller input ... special tissues (eg, blood samples). On the bioinformatics ...
(Date:7/31/2014)... The Kidney Cancer Association (KCA) has established a CNN iReport ... News. , Bill Bro, KCA CEO, says, “We’re pleased ... international news organization. When we began using iReport last month, ... program highlights news of an enzyme that is lost in ... Kidney Cancer News also presents a report on outcomes from ...
(Date:7/30/2014)... PARIS , July 30, 2014  Regeneron ... NYSE: SNY) today announced that the Companies intend to ... pediatric disease priority review voucher in connection with the ... review voucher entitles the holder to designate a BLA ... review from the filing date instead of the standard ...
Breaking Biology Technology:BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6
... most conductive material, discovered in 2004 at the University ... Novoselov, has the potential to revolutionize material science. , ... scientists the Nobel Prize for Physics last year and ... plans for a 50m graphene research hub to be ...
... Novelda AS announced today two new antennas for its CMOS Impulse ... on a Sinuous Antenna geometry. The antenna itself consists of two ... the antenna itself; the lower PCB is a balancing network. The ... can be lowered by attaching a lens. This lens is built ...
... AlloSource, ( www.allosource.org ) a leading developer, ... use in surgical procedures around the world, is among ... Denver Business Journal,s inaugural awards program. With concerns ... employee benefits, the Denver Business Journal sought ...
Cached Biology Technology:Graphene's 'Big Mac' creates next generation of chips 2Wideband Antenna for Novelda Nanoscale Impulse Radar 2AlloSource Named One of Denver's Healthiest Employers 2AlloSource Named One of Denver's Healthiest Employers 3
... Platypus Contact Printing Kit contains choice ... with series of 100 / 200 micron ... or 200 um x 10 mm lines, ... 20, 40 or 60 nm and pitch ...
Request Info...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
... are supplied as 10X concentrated solutions. REact Buffer ... of the REact buffers and one 250 microl ... four 1 ml vials of REact 1 Buffer ... four 1 ml vials of REact 3 Buffer ...
Biology Products: