Navigation Links
Bad mitochondria may actually be good for you
Date:7/22/2009

Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower rate and live longer than normal mice.

Mitochondrial oxidative stress is a popular theory explaining the aging process; over time, reactive oxygen species produced by mitochondria while they make energy slowly accumulate and begin damaging cells, including the mitochondria. Several recent studies have begun to question this theory, though, and to get some more direct answers, Siegfried Hekimi and colleagues at McGill University examined the mitochondria of MCLK1-defective mice, a strain known for its longevity, at various ages.

What they found was that in young (3 month old) MCLK1-defective mice, mitochondria were quite energy inefficient and produced a lot of harmful oxygen radicals; yet surprisingly, when these mice were 23 months old, their mitochondria were working better than normal mice. So, despite the oxidative stress, these mice experienced less deterioration than normal.

To confirm whether MCLK1-defiency could be somehow protective, the researchers crossed MCLK1-defective mice with those lacking SOD2, a major protein antioxidant. Normally, SOD2-defective mice accumulate cellular damage quickly, yet when combined with MCLK1-defiency, they exhibited less damage and oxidative stress.

In explaining this seeming paradox, Hekimi and colleagues suggest that while MCLK1-defective mice produce more oxygen radicals from their mitochondria, their overall inefficiency results in less energy and fewer oxygen radicals being produced in other parts of a cell. Thus while these mice may have some higher risks of damage while young, they accumulate less damage as they age a finding that seems to indicate the mitochondrial stress theory may not be correct.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. How mitochondria get their membranes bent
2. Protein regulates movement of mitochondria in brain cells
3. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
4. A link between mitochondria and tumor formation in stem cells
5. Large reservoir of mitochondrial DNA mutations identified in humans
6. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
7. Hebrew University develops novel approach for treating mitochondrial disorders
8. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
9. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
10. Zebrafish to shed light on human mitochondrial diseases
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/17/2016)... INDUSTRY, Calif. , Nov. 17, 2016  AIC announces that it has just ... servers in organizations that require high-performance scale-out plus high speed data transfer storage solutions. ... ... ... Setting up a ...
(Date:11/15/2016)... 15, 2016  Synthetic Biologics, Inc. (NYSE MKT: ... on the gut microbiome, today announced the pricing ... of its common stock and warrants to purchase ... price to the public of $1.00 per share ... from the offering, excluding the proceeds, if any ...
(Date:11/14/2016)... 2016  xG Technology, Inc. ("xG" or the "Company") ... communications for use in challenging operating environments, announced its ... Management will hold a conference call to discuss these ... Time (details below). Key Recent Accomplishments ... binding agreement to acquire Vislink Communication Systems. The purchase ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... ... , ... There’s a winning streak at Voxx Analytics: the tech company has ... the award last year as well. Employees nominate their companies for the honor, and ... to the tech company’s upbeat environment as a reason. “We don’t answer to Wall ...
(Date:12/9/2016)... ALBANY, New York , December 9, 2016 /PRNewswire/ ... Research states that the top five players in the  ... of 62.7% in the overall market in 2015. Players ... and Perkin Elmer have remained dominant in the global ... persistent efforts to ensure product innovation. Product upgrades and ...
(Date:12/9/2016)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company") ... announce that Biohaven has issued today the following press ... (PRWEB) Dec 9, 2016 - Biohaven Pharmaceutical Holding ... the U.S. Food and Drug Administration ("FDA") has granted ... candidate BHV-0223, an orally dissolving tablet being developed for ...
(Date:12/8/2016)... LONDON , Dec. 8, 2016 This report ... following Product Segments: Acid Based (Humic, Amino, & Fulvic), Extract ... by the following Crop Types: Ornamental & Turf, Row Crops, ... US, Canada , Japan ... , Latin America , and Rest of ...
Breaking Biology Technology: