Navigation Links
Baculovirus-recognizing human cell receptor identified for the first time
Date:9/27/2013

The receptor used by baculovirus to enter and interact with human cells has been identified. This syndecan-1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyvskyl in Finland. The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer. According to the researchers, the identification of the syndecan-1 receptor helps in understanding the ways baculovirus interacts with human cells and sheds further light on the mechanisms the virus uses in human cells.

The study also focused on the role of the syndecan-1 receptor in the cell penetration of baculovirus.

The study was published in the prestigious Journal of Virology. The article was featured in the Spotlight section of the journal, which is reserved for especially interesting and distinguished publications.

Used in drugs and vaccines

Baculovirus is an insect-infecting virus, which is largely utilised in biotechnology applications. Baculoviruses are used, for example, in the manufacturing of Glybera, the first gene therapy of the Western world, and in the manufacturing of the cancer vaccines Cervarix and Provenge, and the influenza vaccine Flublok. The technology is approved by the U.S. Food and Drug Administration, FDA, and the European Medicines Agency, EMA.

Baculovirus is not harmful to human cells, and this is why baculoviruses have become subjects of intensive research also with regard to gene therapy. In gene therapy, DNA to correct genetic errors is transported into cells using a variety of methods. Earlier studies have not been able to identify the receptor that recognises the virus, despite the fact that baculovirus has been studied intensively for decades.


'/>"/>

Contact: Kari Airenne
kari.airenne@uef.fi
358-403-553-131
University of Eastern Finland
Source:Eurekalert

Page: 1

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
4. A birds song may teach us about human speech disorders
5. Scientists produce eye structures from human blood-derived stem cells
6. Human noise has ripple effects on plants
7. Did climate change shape human evolution?
8. Harmless human virus may be able to boost the effects of chemotherapy
9. Study resolves debate on human cell shut-down process
10. Fine-scale analysis of the human brain yields insight into its distinctive composition
11. Bartonella infection associated with rheumatoid illnesses in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014  The second annual Biometrics UnPlugged Executive ... Tampa, Florida on September 15, 2014, ... Technology and Strategy at Samsung, and Philippe de ... of this year,s event is Mobility at the ... "Biometrics UnPlugged: Mobility at the Crossroads of Commerce ...
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... purchased at retail seafood counters in 10 different ... expose consumers to unexpectedly high levels of mercury, ... present a fish of the same species, but ... mislabeling offense, according to new research by University ... of seafood is essential to allow consumers to ...
Breaking Biology News(10 mins):Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3
... Infection control experts at The Johns Hopkins Hospital have ... a bleaching agent into the air and then detoxify ... preventing the spread of multiple-drug-resistant bacteria, or so-called hospital ... hydrogen peroxide vaporizers -- first deployed in several Singapore ...
... West China, Myanmar and Northern Vietnam contain one of the ... area are thousands of caves and gorges. It is only ... plants. This exploration is yielding many new species new to ... study was published in the open access journal ...
... Geosphere articles include additions to several special issues ... Change Offshore New Jersey"; "The ANDRILL McMurdo Ice Shelf (MIS) ... Sea and Beyond: Contributions to Marine Geology in Honor of ... the Colorado River System II." Topics include, 1. ...
Cached Biology News:Hydrogen peroxide vapor enhances hospital disinfection of superbugs 2Hydrogen peroxide vapor enhances hospital disinfection of superbugs 3Hydrogen peroxide vapor enhances hospital disinfection of superbugs 4Cave dwelling nettle discovered in China 2Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 2Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 3Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 4Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 5Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 6Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 7Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 8
(Date:8/19/2014)... Aug. 19, 2014   Synthetic Biologics, Inc. ... novel anti-infective biologic and drug programs targeting specific ... today that its novel C. difficile ... th Interscience Conference on Antimicrobial Agents and ... D.C. Synthetic Biologics, Senior ...
(Date:8/19/2014)... August 19, 2014 Sales Horizons, a ... its online sales skills training course to ... , MedTech clinical staff spend the majority of their ... standalone medical center, or physician practice – providing support ... why stop there? Sales Horizons believes clinical staff are ...
(Date:8/18/2014)... (Aug. 18, 2014) -- A new therapy developed ... (USF) Morsani College of Medicine and Columbia University ... complications of interventional cardiovascular disease treatment. , ... the novel molecular therapy could selectively inhibit blood ... a medical procedure using a balloon catheter to ...
(Date:8/18/2014)... Md. , Aug. 18, 2014 /PRNewswire/ ... maker of advanced consumer medical devices said ... was interviewed by CEOLIVE.TV as part ... The entire interview is available at ... Dr. Kotak explains to investors the unique ...
Breaking Biology Technology:Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3
... work 25 hours a day. So several speakers at the ... drive home the point that "work smarter, not harder" is ... of the University of Wisconsin-Madison School of Business, summed it ... Knetter said. To him, producing more by working more hours ...
... the possibility - make that probability - of data breaches are ... the CEO's top technologist doesn't mind consulting with the legal team, ... the message of attorney Erik Phelps, a partner in the law ... 2007 gathering that since e-mail is now discoverable in court, and ...
... sort - from the globally familiar to the local ... and venerated with a speed never seen before. The ... for brand commentary, both positive and negative, and these ... political brand managers. They now must proactively protect brand ...
Cached Biology Technology:Fusion 2007: Innovation drives productivity in post 24x7 world 2Fusion 2007: In e-legalities, CIOs and lawyers combine to provide business value 2Fusion 2007: In e-legalities, CIOs and lawyers combine to provide business value 3Brand protection in the age of customer engagement 2Brand protection in the age of customer engagement 3Brand protection in the age of customer engagement 4Brand protection in the age of customer engagement 5Brand protection in the age of customer engagement 6
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: