Navigation Links
Bacterium Salmonella enterica regulates virulence according to iron levels found in its surroundings
Date:5/10/2011

associated with food-borne illnesses and is responsible for a number of diseases, from gastroenteritis to systemic infections affecting a wide variety of animals, including humans. During the first stages of infection, the bacterium enters the host through the intestinal epithelium thanks to the presence of a complex system of proteins called T3SS. The activation of T3SS however requires a large amount of energy and therefore depends on many systems to control and make sure its expression is produced just at the right moment.

The study published by UAB researchers indicates that one of the external signals controlling T3SS activation is the level of free iron of the host and that this control is carried out by the Fur protein. Thus, thanks to the Fur protein, when the bacterium detects that levels are high it interacts with its DNA and activates T3SS expression which allows it to invade the epithelium. Once it penetrates the epithelial barrier, however, the levels of free iron reduce drastically due to all of the iron secretion systems the host has at its disposal. In this case T3SS remains silent and thus avoids an unnecessary expenditure of energy.

The study demonstrates for the first time that Fur not only acts as an iron level sensor and regulator of this element in the cell's interior, but also helps the pathogen detect its location during the infection process, acting as a direct activator for the invasion. The research reinforces the idea that Fur is capable of modulating gene expression, adapting it to the needs of each stage of the infection.

The results obtained demonstrate that delving deeper into the study at molecular level of the interactions between host - pathogen in relation to iron must lead in the future to the development of new strategies in the design of vaccines, as well as discover new targets for antibacterial action to fight against infectious diseases. In fact, the Molecular Microbiology Group of the UAB Depar
'/>"/>

Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
2. Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii
3. UTSA biology researchers demystify elusive war zone bacterium
4. Bacterium helps formation of gold
5. Brand new species of bacterium found in the Gullmarsfjord north of Gothenburg
6. Student research team sequences genome of bacterium discovered in Virginia Tech garden
7. Overcoming anthrax bacteriums natural defenses could hold key to new treatments
8. Biosensors reveal how single bacterium gets the message to split into a swimming and a stay-put cell
9. Native-like spider silk produced in metabolically engineered bacterium
10. Cancer-causing bacterium targets tumor-suppressor protein
11. Hot-bunking bacterium recycles iron to boost ocean metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... Techniques used by researchers from the Department of Energy,s ... and its resident bacteria could accelerate efforts to understand more ... In a paper published in the Proceedings of ... analyzed the proteins found in a marine worm known as ...
... The rapid shift from nomadic life to modern-day ... to significant indoor air quality risks that can lead ... the University of North Carolina at Chapel Hill. ... agencies have not performed the research required to pinpoint ...
... University of California, San Diego Jacobs School of ... Challenges Explorations winner, an initiative funded by the ... Todd Coleman, in collaboration with Materials Science and ... of Illinois at Urbana-Champaign, will pursue an innovative ...
Cached Biology News:ORNL protein analysis investigates marine worm community 2Culturally sensitive research in United Arab Emirates pinpoints indoor air quality risks 2Tattoo-like devices for wireless pregnancy monitoring 2Tattoo-like devices for wireless pregnancy monitoring 3
(Date:8/3/2015)... MARIETTA, Ga. , Aug. 3, 2015  MiMedx ... medicine company utilizing human amniotic tissue and patent-protected processes ... the Wound Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic ... will present at the 35 th Annual Canaccord|Genuity ...  Parker H. "Pete" Petit, Chairman and CEO, William ...
(Date:8/3/2015)... ... , ... Nine field days to promote practices that improve soil health will ... Health Partnership , the field days will demonstrate how changing certain practices, such as ... income. , Brent Bible has practiced no-till farming and planted cover crops on his ...
(Date:8/3/2015)... --  Intrexon Corporation (NYSE: XON ) today ... 2015 financial results after the market closes on Monday, ... a conference call at 5:30 PM ET to discuss ... The conference call may be accessed by dialing ... join the "Intrexon Corporation Call."  Participants may also access ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... pumps to its comprehensive line of analytical laboratory equipment. With optimized features, such ... pumps provide a chemically resistant and maintenance-free solution for a broad range of ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2Sterlitech Launches New Line of Vacuum Pumps 2
... Fully Automated, Portable Solution for In-Clinic and Out-Reach Influenza ... ... England, October 3 Enigma Diagnostics, the,life sciences company developing rapid ... European Commission,Framework 7 programme to the RANGER consortium. The award will ...
... progress research from academic settings to ... and therapeutics -, BOSTON, Oct. 2 The ... broader than most might think,including not only the longer-term ... and test therapeutics for,multiple diseases, including diabetes, according to ...
... Foundation for,Biomedical Research (FBR) congratulates Congress for today ... civilian honor it can bestow, the,Congressional Gold Medal. ... improved the health of millions of American citizens ... a surgeon, inventor, educator and,medical statesman make him ...
Cached Biology Technology:Enigma Diagnostics Announces a European Commission Award of EUR3 Million to Fund the Development of a Point of Care Platform for the Rapid Diagnosis of Influenza Infections 2Stem Cell Science Holds Opportunities as Important Tool for Diabetes Research Beyond Cell-Based Treatments 2Stem Cell Science Holds Opportunities as Important Tool for Diabetes Research Beyond Cell-Based Treatments 3Foundation for Biomedical Research Board Chairman Awarded Congressional Gold Medal 2
...
Template and primers for preparation of internal control spots...
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: