Navigation Links
Bacterium Salmonella enterica regulates virulence according to iron levels found in its surroundings
Date:5/10/2011

Salmonella enterica, one of the main causes of gastrointestinal infections, modulates its virulence gene expression, adapting it to each stage of the infection process, depending on the free iron concentration found in the intestinal epithelium of its host. Researchers at Universitat Autnoma de Barcelona (UAB) have demonstrated for the first time that the pathogen activates these genes through the Fur protein, which acts as a sensor of iron levels in its surroundings.

The research, published online in the journal PLoS ONE and entitled "Fur activates the expression of Salmonella enterica pathogenicity island 1 by directly interacting with the hilD operator in vivo and in vitro", was carried out by the Molecular Microbiology Group of the UAB Department of Genetics and Microbiology and coordinated by Dr Jordi Barb. Dr Juan Carlos Alonso from the National Biotechnology Centre also collaborated in the research group.

Iron is an essential part of the development of almost all living organisms. This is why all organisms have developed an iron uptake system which guarantees that they can acquire it from their external environment. However, too much iron in the cell interior can have harmful effects and organisms have systems to control this as well.

In vertebrates, this control produces a first defence barrier known as nutritional immunity which limits the amount of free iron found in biological fluids and prevents the development of pathogens. Only the upper intestinal track, given its anaerobic condition, presents appreciable levels of free iron. In the majority of gram-negative bacteria, such as Salmonella enterica, the control of iron levels is carried out by the Fur protein (Ferric Uptake Regulator), which interacts with the DNA and adjusts the production of uptake and storage systems of this element to the cell's cytoplasm.

Salmonella enterica is one of the most common bacterial pathogens
'/>"/>

Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
2. Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii
3. UTSA biology researchers demystify elusive war zone bacterium
4. Bacterium helps formation of gold
5. Brand new species of bacterium found in the Gullmarsfjord north of Gothenburg
6. Student research team sequences genome of bacterium discovered in Virginia Tech garden
7. Overcoming anthrax bacteriums natural defenses could hold key to new treatments
8. Biosensors reveal how single bacterium gets the message to split into a swimming and a stay-put cell
9. Native-like spider silk produced in metabolically engineered bacterium
10. Cancer-causing bacterium targets tumor-suppressor protein
11. Hot-bunking bacterium recycles iron to boost ocean metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report to ... for Hand Geometry in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and ...
(Date:3/19/2015)... 19, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, announces its biometric payment technology, ... that aired this week on Washington DC,s ... In a segment "The Next Great Thing", host Laura ... to pay, and ,a really big breakthrough in mobile payment.,  ...
(Date:3/17/2015)... 17, 2015 Emotient, the leader in ... announced general availability of Emotient Analytics , ... analysis of facial expressions. The system analyzes videos ... products and services. It delivers audience response metrics ... - as derived from facial evidence of emotional ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... of Tissue Engineering asked 24 leaders in the field what ... critical success by the year 2021 and published their findings ... Engineering is a peer-reviewed journal published by Mary Ann Liebert, ... A survey of the journals editorial boardcomprising leaders in ...
... Researchers at the University of Illinois have developed a ... will fundamentally transform the understanding of how plants and ... The new model takes into account the role of ... to climate change and rising atmospheric carbon dioxide. ...
... Ind. - As the United Nations climate negotiations proceed ... toward quantifying the "socioclimatic" exposure of different countries to ... University and the Abdus Salam International Centre for Theoretical ... the United States - major greenhouse gas-emitting nations that ...
Cached Biology News:Setting a course for the future of tissue engineering 2New model revises estimates of terrestrial carbon dioxide uptake 2New model revises estimates of terrestrial carbon dioxide uptake 3Scientists develop new measure of 'socioclimactic' risk 2Scientists develop new measure of 'socioclimactic' risk 3Scientists develop new measure of 'socioclimactic' risk 4
(Date:3/29/2015)... Whitehouse, NJ (PRWEB) March 29, 2015 ... strict deadlines often required by our pharmaceutical manufacturing clients, ... renewed its sponsorship of the Berkenstock Race Team for ... track requires not only speed, but a strong sense ... same principles that lead to success in the quality ...
(Date:3/27/2015)... Mich. , March 27, 2015  Neogen Corporation ... LLC, has adopted a prearranged trading plan in accordance ... Herbert , Chairman and CEO of Neogen Corporation, is ... of Neogen Corporation common stock. Herbert does ... disclosure was appropriate. The filing is only for a ...
(Date:3/27/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the global pharmaceutical, biotechnology, ... Investigational New Drug (IND) application for WuXi MedImmune,s ... been accepted for review by the China Food ... September 2012, MedImmune, the global biologics research and ...
(Date:3/26/2015)... PRC Clinical, a Silicon-Valley based contract ... executive appointments effective immediately. , Mike Catelani will assume ... of the Board of Directors. Daniel Head is appointed ... will assume the position of Senior Director of Clinical ... (COO), has been appointed to the position of President ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2Neogen CEO adopts 10b5-1 Trading Plan 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3
... the spawning ground for the next wave of high-growth investments, ... market, a diversified range of opportunities await later-stage institutional investors. ... Center for Venture Research at the University ... nearly 11 percent in 2006, with total investments of $25.6 ...
... Gov. Jim Doyle has announced new investments ... engineers in Milwaukee. , ,The investments include an additional $10 ... of Wisconsin and other area institutions, plus $3 million ... University of Wisconsin-Milwaukee , and $500,000 to help design the ...
... - Alfalight , a manufacturer of high-power ... contract worth $1.7 million from the U.S. Army ... develop pump modules suitable for pumping high-power, fiber-laser systems, ... applications and new commercial products. , ,Manoj Kanskar, vice ...
Cached Biology Technology:National angel investment grew 11 percent in `06 2National angel investment grew 11 percent in `06 3Doyle outlines spending for Medical College, UWM 2
Cells are grown in triple flasks, roller bottles, or NUNC Factory. Viability and growth curves are generated from a parallel representative culture....
NovaScreen offers cell biology, cell culture and molecular biology services for companies who lack a cell culture facility....
... effective cell culture services for the production ... at a reasonable price is our primary ... commercial product, we strive toward customer satisfaction. ... bottles, hollow fiber, and bioreactor technologies, Affinity ...
Standard and modified oligonucleotides up to 150 nt-long at any scale for broad applications. Price starts from 30p/base (10 nmole scale)....
Biology Products: