Navigation Links
Bacterial slime helps cause serious disease
Date:5/4/2008

Leptospirosis is a serious but neglected emerging disease that infects humans through contaminated water. Now research published in the May issue of the journal Microbiology shows for the first time how bacteria that cause the disease survive in the environment.

Leptospirosis is a major public health problem in South East Asia and South America, with over 500,000 severe cases every year. Between 5% and 20% of these cases are fatal. Rats and other mammals carry the disease-causing pathogen Leptospira interrogans in their kidneys. When they urinate, they contaminate surface water with the bacteria, which can survive in the environment for long periods.

This led us to see if the bacteria build a protective casing around themselves for protection, said Professor Mathieu Picardeau from the Institut Pasteur in Paris, France. Previously, scientists believed the bacteria were planktonic, living freely in the water. But Professor Picardeau and his team have shown that L. interrogans can make biofilms, which could be one of the main factors controlling survival and disease transmission.

Many different bacteria make biofilms, which protect them against harsh conditions and make them more resistant to antibiotics. They do this by producing a slime, in which the colony can grow unharmed. 90% of the species of Leptospira we tested could form biofilms. It takes L. interrogans an average of 20 days to make a biofilm, said Professor Picardeau.

This ability may contribute to the long-term survival of the bacteria in environmental water and even help them cause disease in humans. Biofilm formation might also play an important role in keeping the bacteria alive in the kidneys of animals such as rats without causing disease.

This finding is a step forward in our understanding of Leptospirosis. We now need to study the mechanism of biofilm formation in both fresh water and renal tubules in animal kidneys, said Professor Picardeau. We hope our research will lead to the identification of new strategies to diagnose and prevent this neglected emerging disease.


'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Tomato pathogen genome may offer clues about bacterial evolution
2. Biologists surprised to find parochial bacterial viruses
3. Biochemists reveal details of mysterious bacterial microcompartments
4. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
5. Bacterial infections in premature babies more common than previously realized
6. New drug targets may fight tuberculosis and other bacterial infections in novel way
7. Small RNA plays parallel roles in bacterial metabolism
8. Scripps research team blocks bacterial communication system to prevent deadly staph infections
9. Legionnaires bacterial proteins work together to survive
10. Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
11. Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2016)... , 19 de diciembre de 2016  Mosaic Biomedicals SL anunció ... acelerado de MSC-1, un anticuerpo humanizado que se espera comenzar a ... con múltiples sitios previstos a lo largo de Europa y Norteamérica. ... MSC-1 es el ... de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa en ciertos ...
(Date:12/15/2016)... , December 15, 2016 Arvato ... an agreement with NuData Security, an award-winning international ... will enable clients to focus on good customer experience, balancing ... regulation. ... In order to provide a one-stop fraud prevention suite, Arvato ...
(Date:12/15/2016)... Dec. 15, 2016  There is much more to ... starting the engine. Continental will demonstrate the intelligence of ... Vegas . Through the combination of the keyless ... and biometric elements, the international technology company is opening ... and authentication. "The integration of biometric elements ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017  HUYA Bioscience International, (HUYA), ... China,s pharmaceutical innovations, announced today a ... Innovation and Investment Company (referred to as CAS Innovation). ... innovations discovered by leading scientists at CAS to meet ... HUYA is the first company to have recognized ...
(Date:1/17/2017)... ... January 17, 2017 , ... LGC ... to its VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 evaluates ... Each VALIDATE® SP2 kit is prepared using the CLSI recommended “equal delta” method ...
(Date:1/17/2017)... 2017 Roka Bioscience, Inc. (NASDAQ: ROKA ), ... the detection of foodborne pathogens today announced the appointment of ... Paul Thomas , the Company,s President and CEO since 2009, who ... Directors.  The changes are effective today. In addition, Ms. ... ...
(Date:1/17/2017)... , Jan. 17, 2017 Research ... report "Molecular Diagnostics - Technologies, Markets and Companies" ... ... diagnostics has increased remarkably during the past few years. More ... developing molecular diagnostics and 342 of these are profiled in ...
Breaking Biology Technology: