Navigation Links
Bacterial slime helps cause serious disease
Date:5/4/2008

Leptospirosis is a serious but neglected emerging disease that infects humans through contaminated water. Now research published in the May issue of the journal Microbiology shows for the first time how bacteria that cause the disease survive in the environment.

Leptospirosis is a major public health problem in South East Asia and South America, with over 500,000 severe cases every year. Between 5% and 20% of these cases are fatal. Rats and other mammals carry the disease-causing pathogen Leptospira interrogans in their kidneys. When they urinate, they contaminate surface water with the bacteria, which can survive in the environment for long periods.

This led us to see if the bacteria build a protective casing around themselves for protection, said Professor Mathieu Picardeau from the Institut Pasteur in Paris, France. Previously, scientists believed the bacteria were planktonic, living freely in the water. But Professor Picardeau and his team have shown that L. interrogans can make biofilms, which could be one of the main factors controlling survival and disease transmission.

Many different bacteria make biofilms, which protect them against harsh conditions and make them more resistant to antibiotics. They do this by producing a slime, in which the colony can grow unharmed. 90% of the species of Leptospira we tested could form biofilms. It takes L. interrogans an average of 20 days to make a biofilm, said Professor Picardeau.

This ability may contribute to the long-term survival of the bacteria in environmental water and even help them cause disease in humans. Biofilm formation might also play an important role in keeping the bacteria alive in the kidneys of animals such as rats without causing disease.

This finding is a step forward in our understanding of Leptospirosis. We now need to study the mechanism of biofilm formation in both fresh water and renal tubules in animal kidneys, said Professor Picardeau. We hope our research will lead to the identification of new strategies to diagnose and prevent this neglected emerging disease.


'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Tomato pathogen genome may offer clues about bacterial evolution
2. Biologists surprised to find parochial bacterial viruses
3. Biochemists reveal details of mysterious bacterial microcompartments
4. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
5. Bacterial infections in premature babies more common than previously realized
6. New drug targets may fight tuberculosis and other bacterial infections in novel way
7. Small RNA plays parallel roles in bacterial metabolism
8. Scripps research team blocks bacterial communication system to prevent deadly staph infections
9. Legionnaires bacterial proteins work together to survive
10. Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
11. Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: