Navigation Links
Bacterial security agents go rogue
Date:4/14/2013

CRISPR, a system of genes that bacteria use to defend themselves against viruses, has been found to be involved in helping some bacteria evade the mammalian immune system.

The results are scheduled for publication Sunday, April 14 in Nature.

CRISPR is itself a sort of immune system for bacteria. Its function was discovered by dairy industry researchers seeking to prevent phages, the viruses that infect bacteria, from ruining the cultures used to make cheese and yogurt. Bacteria incorporate small bits of DNA from phages into their CRISPR region and use that information to fight off the phages by chewing up their DNA.

Now scientists at the Division of Infectious Diseases of the Emory University School of Medicine and the Emory Vaccine Center have shown that Francisella novicida, a close relative of the bacterium that causes tularemia, and another bacterium that causes meningitis, need parts of the CRISPR system to stay infectious. F. novicida, which grows inside mammalian cells, employs parts of CRISPR to shut off a bacterial gene that would otherwise trigger detection and destruction of the bacteria by its host.

Because disabling CRISPR creates a weakened bacterial strain that is easily recognized by the immune system, the finding could accelerate vaccine development. But it is also a broader reminder that in biology, defensive tools can be co-opted for purposes of stealth.

"CRISPR systems are bacterial defenses, but we've found that bacteria can use them offensively to hide from the host immune system and cause disease," says David Weiss, PhD, assistant professor of medicine (infectious diseases) at Emory University School of Medicine and Yerkes National Primate Research Center.

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system has attracted recent attention among scientists for its potential uses in genetic engineering and biotechnology, but its roles in g
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Secrets of bacterial slime revealed
2. Sequencing tracks animal-to-human transmission of bacterial pathogens
3. Antibacterial proteins molecular workings revealed
4. New tool for mining bacterial genome for novel drugs
5. Study: Odd biochemistry yields lethal bacterial protein
6. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
7. Stopping smoking reduces risk of bacterial pneumonia in people with HIV
8. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
9. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
10. OU study suggests the bacterial ecology that lives on humans has changed in the last 100 years
11. New edition of Bacterial Genetics text available
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... currently accepted norms of biofuel production. A commentary published ... of greenhouse gas (GHGs) emissions from bioenergy production are ... of the benefits of biofuels compared to fossil fuels. ... Analysis models of bioenergy production. Life Cycle Analysis (LCA) ...
... be as common as initial HIV infection and is ... study led by researchers at the Johns Hopkins Bloomberg ... Allergy and Infectious Diseases (NIAID). In the first large-scale ... researchers examined the rate of superinfection among a community ...
... with discarded plastics, scientists have been working to produce ... Tel Aviv University researcher is giving the quest for ... making them tougher than ever before. Prof. ... a super-strength polypropylene one of the world,s most ...
Cached Biology News:Environmental benefit of biofuels is overestimated, new study reveals 2New data suggests HIV superinfection rate comparable to initial HIV infection 2New data suggests HIV superinfection rate comparable to initial HIV infection 3Steel-strength plastics -- and green, too! 2Steel-strength plastics -- and green, too! 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... , , , ... cord blood banks, today announced that Shannon Miller , a 7-time ... and will appear in a series of advertising and public awareness campaigns ... ) , , Considered "The Most Decorated American ...
... 24 Boston Scientific Corporation (NYSE: BSX ) will ... trial on Tuesday, September 1, at 8:00 a.m. ET / 2:00 ... call will be hosted by Ray Elliott, President and Chief Executive ... Management; and Arthur Moss, M.D., Professor of Medicine at the University ...
... BOZEN, Italy, August 24 ... its recent partnership announcement with McKesson, it,has received ... North American,customers in just a few days since ... policies prevent them from publicly,commenting on industry events, ...
Cached Biology Technology:7-Time Olympic Medalist Shannon Miller Endorses StemCyte 2Boston Scientific to Webcast Conference Call Discussing Results of Landmark MADIT-CRT Trial 2Health Robotics Receives Overwhelming Support from its Customers for its McKesson-CytoCare Partnership 2Health Robotics Receives Overwhelming Support from its Customers for its McKesson-CytoCare Partnership 3Health Robotics Receives Overwhelming Support from its Customers for its McKesson-CytoCare Partnership 4
... protein A media yield highly purified ... to analysis of other immunoglobulin classes, ... purification. Protein A binds to the ... from mammalian species. This ready-to-use, bottled ...
... bis- (3-D-Gluconamidopropyl)deoxycholamide White solid. HYGROSCOPIC. ... CHAPSO. Has reduced electrostatic interactions that do ... DEAE-cellulose. Aggregation number: 8-16. Purity: ≥95% ... O. Aggregation number 8 - 16, CMC ...
Goat Anti-Horse IgG(T) Antibody, Unconjugated...
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Biology Products: