Navigation Links
Bacterial plasmids -- the freeloading and the heavy-lifters -- balance the high price of disease
Date:2/1/2012

BLOOMINGTON, Ind. -- Studying self-replicating genetic units, called plasmids, found in one of the world's widest-ranging pathogenic soil bacteria -- the crown-gall-disease-causing microorganism Agrobacterium tumefaciens -- Indiana University biologists are showing how freeloading, mutant derivatives of these plasmids benefit while the virulent, disease-causing plasmids do the heavy-lifting of initiating infection in plant hosts. The research confirms that the ability of bacteria to cause disease comes at a significant cost that is only counterbalanced by the benefits they experience from infected host organisms.

A. tumefaciens is widely studied for its remarkable biology not only because it causes disease in over 140 genera of broadleaf plants, including fruit trees, grapes, roses and walnut trees, but also because it is considered one of the most important tools for plant biotechnology: It is the only organism known to routinely engage in inter-kingdom lateral gene transfer. A. tumefaciens infects host plants by transferring a portion of its own DNA into plant cells, and this integrated bacterial DNA is expressed in the plant cells, leading diseased plants to develop tumors and produce resources that benefit the pathogen.

"We've identified two types of costs the plant pathogen A. tumefaciens pays for traits conferred by genes carried on plasmids," said lead author Thomas G. Platt, a postdoctoral researcher in the IU Bloomington College of Arts and Sciences' Department of Biology. "There is a relatively low cost of maintaining the tumor-inducing virulence plasmid, but there is also a dramatically large cost of expressing the genes that are required to infect plants."

Plants with crown gall disease can also benefit a second type of plasmid that can be found in A. tumefaciens: Nonpathogenic plasmids that lack the genes required to infect plants, yet are still able to benefit from the breakdown of nu
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene against bacterial attack unravelled
2. Predatory bacterial swarm uses rippling motion to reach prey
3. Nature study demonstrates that bacterial clotting depends on clustering
4. Shifts in soil bacterial populations linked to wetland restoration success
5. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
6. Scientists present moving theory behind bacterial decision-making
7. Scientists build roach motel for nasty bugs of the bacterial variety
8. Bacterial biofilms as fossil makers
9. Winter brings flu, summer brings bacterial infections
10. Computation and genomics data drive bacterial research into new golden age
11. New research lights up chronic bacterial infection inside bone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial plasmids -- the freeloading and the heavy-lifters -- balance the high price of disease
(Date:4/17/2014)... that devastate honeybees in Europe, Asia and the United ... appear to be impacting native honeybee populations at this ... invasive pests include including Nosema microsporidia and ... to be resilient to these invasive pests, which suggests ... in Europe, Asia and the United States currently are ...
(Date:4/17/2014)... warning on the possible effects of gases such as ... that of carbon dioxide. Now a team of Swiss-German ... regenerable electron acceptors which helps explain why large amount ... released to the atmosphere. However, there are worries that ... a vicious cycle to release large amounts of methane ...
(Date:4/17/2014)... of Texas Medical Branch at Galveston are the ... radiation for cervical cancer should begin colorectal cancer ... UTMB researchers, finding a high incidence of secondary ... radiation, offer new recommendations that the younger women ... eight years after their initial cervical cancer diagnosis ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Methane climate change risk suggested by proof of redox cycling of humic substances 2Radiation therapy for cervical cancer increases risk for colorectal cancer 2
... Aquaculture production of seafood will probably remain the ... according to an assessment published in the January 2009 ... S. Diana of the University of Michigan at Ann ... harmful effects of aquaculture, the technique may, when practiced ...
... Yan Liu imagine and assemble intricate structures on a ... DNA molecule, a versatile building material offering near limitless ... issue of Science , Yan and Liu, researchers ... of Chemistry and Biochemistry, reveal for the first time ...
... Hopkins neuroscientists has worked out how some newly discovered ... with the brain. The report appears online this week ... are a small number of nerve cells in the ... in the retinarods and conesmelanopsin-containing cells are not used ...
Cached Biology News:Aquaculture's growth seen as continuing 2The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes 2The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes 3Bright lights, not-so-big pupils 2Bright lights, not-so-big pupils 3
(Date:1/15/2014)... "The interface is the device," Nobel laureate Herbert ... to be found at the junctures where layers ... of nanotechnology, the interfaces between layers of metal ... such high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics ...
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
Breaking Biology Technology:A deeper look at interfaces 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... Technologies Inc. , a provider of medical imaging devices and ... has received a notice from the staff of the ... to delisting after missing another opportunity to file financial reports. ... the quarter ended June 30 would serve as an additional ...
... - A new biofuels company spun out of Lucigen Corp. ... presented with the second of two state grants. , ,C5-6, ... will receive a $115,000 grant as part of the Bio-Based ... was on hand to announce the grant, which is part of ...
... Madison, Wis. - Wisconsin-based high-tech startup and ... far-flung investors. The most recent example of this ... that is developing laboratory tools for analysis of ... of protein targets, quantitative microarrays, and related products, ...
Cached Biology Technology:Madison business receives $115,000 of new state biofuels funding 2Wisconsin start up Primorigen Biosciences corrals out-of-state investment 2