Navigation Links
Bacterial plasmids -- the freeloading and the heavy-lifters -- balance the high price of disease
Date:2/1/2012

BLOOMINGTON, Ind. -- Studying self-replicating genetic units, called plasmids, found in one of the world's widest-ranging pathogenic soil bacteria -- the crown-gall-disease-causing microorganism Agrobacterium tumefaciens -- Indiana University biologists are showing how freeloading, mutant derivatives of these plasmids benefit while the virulent, disease-causing plasmids do the heavy-lifting of initiating infection in plant hosts. The research confirms that the ability of bacteria to cause disease comes at a significant cost that is only counterbalanced by the benefits they experience from infected host organisms.

A. tumefaciens is widely studied for its remarkable biology not only because it causes disease in over 140 genera of broadleaf plants, including fruit trees, grapes, roses and walnut trees, but also because it is considered one of the most important tools for plant biotechnology: It is the only organism known to routinely engage in inter-kingdom lateral gene transfer. A. tumefaciens infects host plants by transferring a portion of its own DNA into plant cells, and this integrated bacterial DNA is expressed in the plant cells, leading diseased plants to develop tumors and produce resources that benefit the pathogen.

"We've identified two types of costs the plant pathogen A. tumefaciens pays for traits conferred by genes carried on plasmids," said lead author Thomas G. Platt, a postdoctoral researcher in the IU Bloomington College of Arts and Sciences' Department of Biology. "There is a relatively low cost of maintaining the tumor-inducing virulence plasmid, but there is also a dramatically large cost of expressing the genes that are required to infect plants."

Plants with crown gall disease can also benefit a second type of plasmid that can be found in A. tumefaciens: Nonpathogenic plasmids that lack the genes required to infect plants, yet are still able to benefit from the breakdown of nu
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene against bacterial attack unravelled
2. Predatory bacterial swarm uses rippling motion to reach prey
3. Nature study demonstrates that bacterial clotting depends on clustering
4. Shifts in soil bacterial populations linked to wetland restoration success
5. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
6. Scientists present moving theory behind bacterial decision-making
7. Scientists build roach motel for nasty bugs of the bacterial variety
8. Bacterial biofilms as fossil makers
9. Winter brings flu, summer brings bacterial infections
10. Computation and genomics data drive bacterial research into new golden age
11. New research lights up chronic bacterial infection inside bone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial plasmids -- the freeloading and the heavy-lifters -- balance the high price of disease
(Date:10/15/2014)... , Oct. 15, 2014 Sandata ... for home and community-based care, today announced it ... implementing Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™) ... is a home health company founded in 1996 ... . The study details ...
(Date:10/15/2014)... linked increased resistance to bacterial pneumonia in female mice ... estrogen. , Females are naturally more resistant to respiratory ... has shown that increased resistance to bacterial pneumonia in ... synthase 3 (NOS3). They also show that this enzyme ... sex hormone estrogen. , The team, lead by Professor ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to inhibit ... development of skin cancers by turning on an enzyme ... cells. , Previously considered protective, SIRT6 is part of ... regulate genomic stability and prevent some of the genetic ... which can lead to cancer. This study, in the ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... of light for more than a billion people in developing ... overlooked in greenhouse gas estimates, according to a new study ... the University of Illinois. Results from field and ... kerosene in wick lamps used for light in 250-300 ...
... varieties with higher yields and enhanced nutritional content, researchers ... with scientists at nine other institutions in an attempt ... endeavor, led by researchers at the U.K.-based Biotechnology and ... in the journal Nature . "This work ...
... white blood cells has a surprising second role in protecting ... researchers report. The molecule, microRNA-223, affects how cells respond to ... and thus the cells, likelihood of suffering permanent damage. ... very specific effects in the brain, one that could be ...
Cached Biology News:Study IDs kerosene lamps as big source of black carbon 2UC Davis researchers aid effort to sequence the complex wheat genome 2Double duty: Immune system regulator found to protect brain from effects of stroke 2
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market report defines ... with analysis and forecast of revenue. , Browse ... Market report, to get an idea of the ... of the segmentation in the Americas inorganic refrigerants ... figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html , Inorganic ...
(Date:10/22/2014)... 2014 Involution Studios , a ... a new infographic, Understanding Ebola . The ... designed, easy to follow informative tool for anyone wanting ... symptoms and prevention. , "As the news has spread ... Ebola outbreak represents not only a healthcare crisis with ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
(Date:10/22/2014)... , Oct. 22, 2014   Synthetic Biologics, Inc. ... pathogen-specific therapies for serious infections and diseases, announced today ... a Notice of Allowance for a composition of matter ... C. difficile program, SYN-004. This is Synthetic Biologics, ... the U.S. and adds to the Company,s extensive ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4
... Joshua Hare to Chair the Board LA JOLLA, Calif., ... CDXP) announced today the formation of a Medical Advisory ... program of CDP-1050 for the treatment of heart failure.The ... in the design and oversight of the planned CDP-1050 ...
... /PRNewswire-Asia-FirstCall/ -- China Biologic,Products, Inc. (OTC ... the,Company,), one of the leading plasma-based ... China (,PRC,), today announced that the ... Products Co.,Ltd. (,Shandong Taibang,) has been ...
... Pain IndicationsLA JOLLA, Calif., Feb. 11 TorreyPines ... announced that oral administration of NGX426, an AMPA/kainate-type ... healthy male and female subjects when dosed once ... this Phase I trial demonstrating the safety and ...
Cached Biology Technology:Cordex Pharma Forms Heart Failure Medical Advisory Board 2Cordex Pharma Forms Heart Failure Medical Advisory Board 3Cordex Pharma Forms Heart Failure Medical Advisory Board 4Cordex Pharma Forms Heart Failure Medical Advisory Board 5China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 2China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 3First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 2First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 3First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 4
... of next-generation features into a small-footprint design, ... flexible laboratory solutions. It puts every aspect ... dispensing, and integrations into a single, ... as it is efficient and economical. The ...
... The mini incubation trays are ... to screen antigens that have ... Each tray has eight 10.5 ... that accommodate strips cut from ...
... The GenomeLab GeXP Genetic Analysis System ... scalable, multiplexed PCR*. The systems patented ... standard multiplexed PCR analysis to just a ... GeXP delivers more genes per reaction and ...
... Kit is a simple high performance method ... Removes detergents without significant dilution of protein ... on the Detergent-OUT Spin column and collect ... are suitable for removing detergent from a ...
Biology Products: