Premature babies are subject to a host of threats that can result in fetal/neonatal disease. In a study published in the January 2008 issue of the American Journal of Obstetrics & Gynecology, researchers from the University of AlabamaBirmingham Medical School and the Drexel University College of Medicine found that genital mycoplasmas are a frequent cause of congenital fetal infection. 23% of neonates born between 23 and 32 weeks of gestation have positive umbilical blood cultures for two genital mycoplasmas (bacteria lacking cell walls): Ureaplasma urealyticum and Mycoplasma hominis.
Although Ureaplasma urealyticum and Mycoplasma hominis are found in 80% of vaginal and cervical fluids, infants are not generally screened for these bacterial infections. The finding that about one-quarter of early preterm infants is already infected at birth is important in reducing adverse outcomes. These newborns had a higher incidence of neonatal systemic inflammatory response syndrome (SIRS), higher incidence of bronchopulmonary dysplasia (BPD), higher serum concentrations of interleukin (IL)-6 and more evidence of placental inflammation than those with negative cultures. The earlier the gestational age at delivery, the higher the rate of a positive umbilical cord blood culture.
The data, derived from the Alabama Preterm Birth Study, included 457 consecutive singleton deliveries of infants born at 23-32 weeks gestation from 1996 to 2001. This study focuses on a subset of 351 women/infant pairs in the population who had umbilical cord blood cultures for U. urealyticum and M. hominis.
Writing in the article, Robert Goldenberg, M.D., Professor, Department of Obstetrics and Gynecology, Drexel University College of Medicine, states, Given the frequency of these infections and their association with SIRS and likely with BPD, it seems reasonable to determine if infants in these categories would benefit from routine culture for Ureaplasma urealyticum and/o
'/>"/>
| Contact: Pamela Poppalardo ajogmedia@elsevier.com 212-633-3944 Elsevier Health Sciences Source:Eurekalert |
Related biology news :
1. Legionnaires bacterial proteins work together to survive
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Small RNA plays parallel roles in bacterial metabolism
4. New drug targets may fight tuberculosis and other bacterial infections in novel way
5. Gamma globulin effective in treating eye infections caused by adenoviruses
6. UCLA/VA partners with ASU to advance biosensor technology for urinary tract infections
7. Nutrient pollution drives frog deformities by ramping up infections, says CU-Boulder study
8. Evidence of a relationship between swimming babies and infections
9. Handbook helps parents deal with childhood infections
10. Gamma interferon could aid fight against fungal infections
11. Best treatment identified to reduce deadly Staph infections
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |