Navigation Links
Bacterial gut biome may guide colon cancer progression
Date:4/4/2014

human innate immune system to promote healing and prevent the spread of infection.

In these studies, Rauscher and his colleagues injected anti-inflammatory proteins produced by EPEC (Enteropathogenic Escherichia coli) bacteria into colon epithelial cells. One of these proteins, NLEE, is an enzyme that targets TAB2, a human scaffolding protein involved in the transduction of chemical signals in the NF-κB pathway. Targeting TAB2 results in the inactivation of numerous inflammatory activities in the gut.

Rauscher and colleagues looked for other human proteins that could be targeted by NLEE. Remarkably, they found that NLEE also has the capability of shutting off a protein, ZRANB3 involved in DNA repair. If bacterially infected colon cells can no longer repair damage to their DNA, mutations will accumulate, which will promote cancer growth.

In addition, along with collaborators in the laboratory of Feng Shao, Ph.D., at the National Institute of Biological Sciences in Beijing, China, they demonstrated that NLEE proteins attack TAB2 and ZRANB3 by methlylating these proteinsessentially adding a single methyl moleculewhich unfolds the target proteins. NLEE appear to specifically attack a structure on TAB2 and ZRANB3 known as a "zinc finger," which is a common structural motif used in many other proteins. When the researchers determined the structure of NLEE, they found a deep cleft on the protein specific to a certain zinc finger pattern. A survey of EPEC-infected colon cells showed that this zinc finger pattern was common to at least three DNA repair enzymes, suggesting that NLEE has the capability of having widespread influence on mechanisms in the colon that typically prevent cancer growth.

"Our results suggest that some infective intestinal bacteria, which normally can simply cause gastric distress, have the capability of inducing genetic changes (by limiting repair) in our intestinal cells which could lead t
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bacterial reporters that get the scoop
2. Spread of antibiotic resistance understood by unravelling bacterial secretion system
3. Bacterial fibers critical to human and avian infection
4. £4 million to tackle spread of bacterial infections
5. Puzzling question in bacterial immune system answered
6. Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
7. Gut microbes affect MicroRNA response to bacterial infection
8. In surprise finding, blood clots absorb bacterial toxin
9. New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome
10. Structure of bacterial nanowire protein hints at secrets of conduction
11. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... like houses, need building materials for their walls. And as ... at just the right moment to protect and allow the ... of the global Ludwig Institute for Cancer Research (LICR) has ... but has also conducted proof-of-principle studies that indicate taking away ...
... coloured males because they are easier to see and ... following her study of fish speciation in the East ... preference and eventually to speciation. , Evolutionary theory ... different characteristics in males. Yet females often pay attention ...
... word pollen to most people and it triggers thoughts of ... Alberta researcher has found an important spin-off for this fine ... from the Department of Biological Sciences at the U of ... pollen on boreal lakes. Rich in nutrients, pollen is an ...
Cached Biology News:Choosy females make colourful males 2
(Date:11/26/2014)... SoundConnect , an award winning ... announce that Darren Suders has joined the team as ... drive the partner program through innovative offerings, ... , Darren brings more than 10-years of channel telecommunication ... channel operations, from policy development, to partner education and ...
(Date:11/26/2014)... /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio il lancio ... di Hi Europe 2014 (dal 2 al 4 dicembre, ... della curcumina con la maggiore biodisponibilità di sempre, con ... approvati dalle norme europee. La curcumina è ... ( Curcuma longa ) che è stata associata con ...
(Date:11/24/2014)... , Belgium , Nov. 24, 2014 ... sciences company focused on developing diagnostic tests for cancer and ... cancer study will be presented at the Science for Business ... Belgium . The data come from VolitionRx,s ... at the Pneumology department of the Centre Hospitalier Universitaire (CHU) ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 2014 ... Dihydrazide Industry is a professional and in-depth research ... Adipic Dihydrazide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3
... , , , BOULDER, ... LENA Autism Screen (LAS) to 91 percent for children 24 to 48 ... is now as accurate or more accurate than other autism screens currently ... http://www.newscom.com/cgi-bin/prnh/20090210/LA69114 ) , , "We,re thrilled with this leap ...
... , , , ... NGSX ), a biopharmaceutical company focused on developing and ... and Chief Executive Officer, is scheduled to present at two upcoming ... Healthcare Conference, to be held September 9 - 11th, 2009, and ...
... , , , ... in vivo imaging from research through medicine, announced today the ... measuring and monitoring apoptosis and cell death in vivo . ... established Annexin labeling standard in in vitro research. It is ...
Cached Biology Technology:Advancement Made in Automatic Autism Screen Increases Accuracy to 91%, Scheduled for Release This Month 2Advancement Made in Automatic Autism Screen Increases Accuracy to 91%, Scheduled for Release This Month 3NeurogesX to Present at Upcoming Fall Conferences 2NeurogesX to Present at Upcoming Fall Conferences 3NeurogesX to Present at Upcoming Fall Conferences 4VisEn Launches New Annexin-Vivo 750 Fluorescence Molecular Imaging Agent 2VisEn Launches New Annexin-Vivo 750 Fluorescence Molecular Imaging Agent 3
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
PlusOne Acrylamide PAGE, 1 kg. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Biology Products: