Navigation Links
Bacterial gut biome may guide colon cancer progression
Date:4/4/2014

human innate immune system to promote healing and prevent the spread of infection.

In these studies, Rauscher and his colleagues injected anti-inflammatory proteins produced by EPEC (Enteropathogenic Escherichia coli) bacteria into colon epithelial cells. One of these proteins, NLEE, is an enzyme that targets TAB2, a human scaffolding protein involved in the transduction of chemical signals in the NF-κB pathway. Targeting TAB2 results in the inactivation of numerous inflammatory activities in the gut.

Rauscher and colleagues looked for other human proteins that could be targeted by NLEE. Remarkably, they found that NLEE also has the capability of shutting off a protein, ZRANB3 involved in DNA repair. If bacterially infected colon cells can no longer repair damage to their DNA, mutations will accumulate, which will promote cancer growth.

In addition, along with collaborators in the laboratory of Feng Shao, Ph.D., at the National Institute of Biological Sciences in Beijing, China, they demonstrated that NLEE proteins attack TAB2 and ZRANB3 by methlylating these proteinsessentially adding a single methyl moleculewhich unfolds the target proteins. NLEE appear to specifically attack a structure on TAB2 and ZRANB3 known as a "zinc finger," which is a common structural motif used in many other proteins. When the researchers determined the structure of NLEE, they found a deep cleft on the protein specific to a certain zinc finger pattern. A survey of EPEC-infected colon cells showed that this zinc finger pattern was common to at least three DNA repair enzymes, suggesting that NLEE has the capability of having widespread influence on mechanisms in the colon that typically prevent cancer growth.

"Our results suggest that some infective intestinal bacteria, which normally can simply cause gastric distress, have the capability of inducing genetic changes (by limiting repair) in our intestinal cells which could lead t
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bacterial reporters that get the scoop
2. Spread of antibiotic resistance understood by unravelling bacterial secretion system
3. Bacterial fibers critical to human and avian infection
4. £4 million to tackle spread of bacterial infections
5. Puzzling question in bacterial immune system answered
6. Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
7. Gut microbes affect MicroRNA response to bacterial infection
8. In surprise finding, blood clots absorb bacterial toxin
9. New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome
10. Structure of bacterial nanowire protein hints at secrets of conduction
11. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... in the September 2007 issue of the Journal ... ARTICLE HIGHLIGHTS Renal transplant recipients genetic ... chemicals New anti-inflammatory compound discovered Thematic Review: Understanding how ... Renal transplant recipients genetic makeup does not negatively impact ...
... Pennsylvania researchers have designed a nanoscale system to ... external forces. By combining microfabricated cantilevers ... sensors, the study showed that cells respond to ... between cells and their environment. The study also ...
... new light on the health effects of exposure to dust ... Center disaster on September 11, 2001. The data, drawn from ... the 25,000 rescue and recovery workers enrolled in the Registry ... is 12 times what would be normally expected for the ...
Cached Biology News:Story ideas from the Journal of Lipid Research 2Story ideas from the Journal of Lipid Research 3Story ideas from the Journal of Lipid Research 4Story ideas from the Journal of Lipid Research 5Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 3
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... Early ... 2008 -, ... products company, announced today that it,has received a "positive opinion" recommending European ... chronic,renal failure and chemotherapy-induced anemia. Retacrit is a similar,biologic -- often referred ...
... WALNUT CREEK, CA It is better to be looked over ... of wisdom for genome data-miners of today. Data that ... to the discerning eye. Such is the case of a ... Institute (DOE JGI) of the massive backlog of microbial genome ...
... delicious when cooked in a white wine broth, but ... put in a pot: they stick to virtually all ... tenacity. , Northwestern University biomedical engineer Phillip B. Messersmith ... of the bonds; now he has produced a versatile ...
Cached Biology Technology:Hospira's Biosimilar Epoetin Retacrit(TM) Receives Positive Opinion Recommending EU Approval 2Hospira's Biosimilar Epoetin Retacrit(TM) Receives Positive Opinion Recommending EU Approval 3Massive reanalysis of genome data solves case of the lethal genes 2Sticky mussels inspire biomedical engineer yet again 2Sticky mussels inspire biomedical engineer yet again 3
... StabilCoat Immunoassay Stabilizer is an aqueous ... and other non-toxic chemicals in a PBS ... 7.4. This product does not contain ... the conformation and activity of dried protein ...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
Rabbit polyclonal antibody to NMDA NR2B [Tyr1336]...
... tetrasodium bromide), 50mg/vial. MTT is a pale ... cells to yield a dark blue formazan ... even freshly dead cells do not cleave ... a component of Chemicons MTT assay kit, ...
Biology Products: