Navigation Links
Bacterial genes tell the tale of an outbreak's evolution
Date:11/13/2011

ms Biology. When Michel and Lieberman, who share credit as first authors on the Nature Genetics paper, crunched the numbers on their B. dolosa samples, the dN/dS ratio was 1.0. Across the genomes of their entire sample set, the changes appeared perfectly random.

"It wasn't a small effect," Lieberman said. "It was no effect." But the finding defied previous observations and common sensebacteria face pressure from antibiotics, pressure from the immune system, pressure from one another. Even in test tubes, bacteria evolve.

Maybe, Lieberman suggested, they were asking the wrong question. What if the genome-wide dN/dS ratio was a red herring, when what they really wanted to know was what was happening to specific genes? "Tami had the key insight," said Kishony. If a mutation has any effect, it's typically harmful. Randomly tune your car, and you're apt to get a broken car. In a gene pool, purifying selection weeds out those harmful changes even as positive selection spreads helpful ones. Average those positive and negative effects, and both might disappear.

Sure enough, when Lieberman and Michel analyzed the same data another wayseparating genes that had mutated in multiple patients from those that had mutated just oncemost genes registered a dN/dS of slightly less than one, evidence of widespread purifying selection. Seventeen genes scored much higher, strong evidence of positive selection. Tellingly, bacteria from different patients showed pressure on the same genes, which evolved in similar ways.

"These data told us what the pathogen experiences as its main challenges," Kishony said. Some of those challenges were expected: Genes linked to antibiotic resistance, adhesion and immune response faced pressure to adapt.

One of the most striking findings among such genes was a stop codon, seen in about 70 percent of the strains, in a previously unstudied enzyme linked to genes involved in the synthesis of lipopolysaccharide (
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Texas A&M center confronts antibiotic crisis with potential new bacterial treatment
2. Researchers generate first complete 3-D structures of bacterial chromosome
3. University of California Santa Barbara study reveals how gas, temperature controlled bacterial response to Deepwater Horizon spill
4. UTHealth student earns fellowships to research major source of bacterial infections
5. Bacterial attack strategy uses special delivery of toxic proteins
6. New contrast agents detect bacterial infections with high sensitivity and specificity
7. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
8. Bacterial roundabouts determine cell shape
9. Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
10. Understanding a bacterial immune system 1 step at a time
11. Could bacterial hitchhikers influence formation of new host species?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Roald Amundsen became the first man to reach the ... years later, an international team of scientists led by ... proven that air pollution from industrial activities arrived long ... from widely spaced locations around the Antarctic continent, including ... and precise reconstruction to date of lead pollution over ...
(Date:7/27/2014)... new species of mayfly in the southern Western Ghats, a ... this is the first time that any mayfly belonging to ... India. , The new species, called Labiobaetis soldani , ... substantial contribution to the understanding of the Ephemeroptera of Palaearctic ... that describes the new mayfly in the Journal of ...
(Date:7/27/2014)... single computer cannot always find the solution a user ... cluster of computers that analyze a massive data set ... history to present you with targeted ads, and how ... movie. But big data is about more than just ... are generating unprecedented quantities of information. That data may ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... one equal one. But biological engineer Chang Lu has ... to electrically fuse cells - a vital technology for ... , "The only current method for electrofusion requires ... Lu, a professor of agricultural and biological engineering at ...
... failed experiment turned out to be anything but for bacteriologist ... should have been a routine procedure wouldn't work, he made ... biological tool for destroying bacterial pathogens - one that doesn't ... led to the startup of a promising new biotechnology firm ...
... of protein crucial for the growth of brain cells ... formation of long-term memories, according to researchers at UC ... of, and treatments for, cognitive decline associated with normal ... findings appear in the early online edition of the ...
Cached Biology News:The power of one: A simpler, cheaper method for cell fusion 2The power of one: A simpler, cheaper method for cell fusion 3'Failed' experiment yields a biocontrol agent that doesn't trigger antibiotic resistance 2'Failed' experiment yields a biocontrol agent that doesn't trigger antibiotic resistance 3Proteins necessary for brain development found to be critical for long-term memory 2
(Date:7/28/2014)... 2014 Research and Markets has announced ... 2014-2018" report to their offering. ... a technique used to determine the size of a particle ... crucial to analyze the size of particles as it can ... is performed to determine the behavior and nature of a ...
(Date:7/25/2014)... Trillions of bacteria live in each person,s digestive tract. ... food and stave off harmful infections, but their role ... help shed light on the role of these bacteria, ... Eric Alm recently tracked fluctuations in the bacterial populations ... findings, described in the July 25 issue of the ...
(Date:7/25/2014)... 25, 2014 The Conferee Networking committee ... for Conferee Networking. These two-hour sessions provide a unique ... and resolve problems, discuss new techniques, or brainstorm new ... submit a topic for consideration is August 31, 2014, ... The Conferee Networking committee will review the topics, and ...
(Date:7/25/2014)... , July 25, 2014 Sinovac Biotech Ltd. ... products in China , today announced that ... quarter ended June 30, 2014, after market close on Thursday, ... call prior to the market opening on Friday, August 15, ... 8:00 p.m. China Standard Time) to review the Company,s financial ...
Breaking Biology Technology:Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... May 22 Amarin Corporation plc,(NASDAQ: AMRN ) ... first,tranche of its previously announced $60 million private placement. ... placement agents, fees,and estimated offering expenses, will be approximately ... has appointed to its Board,representatives of the four largest ...
... Nektar,Therapeutics (Nasdaq: NKTR ) announced today that ... Chief Operating Officer and Head of the,PEGylation Business ... of the PEGylation Business Unit, including research,and manufacturing, ... will also,serve as Chairman of Nektar India Pvt., ...
... (Nasdaq and SWX: BMRN) will host a Research ... June 5, 2008 from,7:30 a.m. to 11:30 a.m. ... York City. Members,of BioMarin,s senior management team will ... information about advancements in the,research and development pipeline ...
Cached Biology Technology:Amarin Announces Completion of the First Tranche of $60 Million Private Placement 2Amarin Announces Completion of the First Tranche of $60 Million Private Placement 3Amarin Announces Completion of the First Tranche of $60 Million Private Placement 4Amarin Announces Completion of the First Tranche of $60 Million Private Placement 5Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 2Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 3BioMarin to Host Research and Development Day June 5th 2
... The Jouan RCT series of refrigerated ... suited to trapping of low volatility/aqueous solvents ... with RC10 and other vacuum concentrators/centrifugal evaporators. ... in cooling systems such as used in ...
Black 96 Well Plate EB, RE Bottom...
... high durability and capacity with unequalled ease ... prevents vibration, allowing the unit to run ... part, from the large rubber block vibration ... platform is designed to last through years ...
...
Biology Products: