Navigation Links
Bacterial attack strategy uses special delivery of toxic proteins
Date:7/21/2011

When competing for food and resources, bacteria employ elaborate strategies to keep rival cells at bay. Scientists have now identified a pathway that allows disease-causing bacteria to attack other bacterial cells by breaking down their cell wall.

Pseudomonas aeruginosa is a type of bacteria readily found in everyday environments. It easily forms colonies in a wide variety of settings, including medical devices, body organs and skin wounds. This allows it to cause disease and act as a major pathogen, particularly in hospitals.

Research led by Joseph Mougous, assistant professor of microbiology at the University of Washington in Seattle, provides new insight into how P. aeruginosa acts as a master colonizer and maintains a competitive advantage over other bacteria. The study, which will be published in the July 21 issue of the journal Nature, describes how P. aeruginosa uses a specialized secretion system--the type VI secretion system--to deliver toxic proteins to recipient opponent bacteria. These proteins break down a structural protein known as peptoglycan, which the authors describe as "an Achilles heel of bacteria." Degrading this target in turn causes the breakdown of the protective cell wall of competitor bacteria. Furthermore, P. aeruginosa protects itself from this attack by using specific, strategically localized immunity proteins that counteract the effects of the toxic proteins it secretes.

This discovery not only sheds light on P. aeruginosa's pathogenic success, but is also interesting from an evolutionary perspective as it highlights the functional similarity between the bacterial type VI secretion system and viruses that infect bacteria, or bacteriophages.


'/>"/>

Contact: Nicole Garbarini
ngarbari@nsf.gov
703-292-8463
National Science Foundation
Source:Eurekalert  

Page: 1

Related biology news :

1. New contrast agents detect bacterial infections with high sensitivity and specificity
2. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
3. Bacterial roundabouts determine cell shape
4. Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
5. Understanding a bacterial immune system 1 step at a time
6. Could bacterial hitchhikers influence formation of new host species?
7. Bacterial genome may hold answers to mercury mystery
8. Bacterial wipes research study
9. Asthma tied to bacterial communities in the airway
10. New method attacks bacterial infections on contact lenses
11. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial attack strategy uses special delivery of toxic proteins
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/18/2016)... --> --> Competitive Landscape ... Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which is ... & security companies in the border security market and ...
(Date:3/15/2016)... March 15, 2016 Yissum Research Development ... technology-transfer company of the Hebrew University, announced today the ... sensing technology of various human biological indicators. Neteera Technologies ... million from private investors. ... the detection of electromagnetic emissions from sweat ducts, enables ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of ... board-certified in surgery and surgery of the hand by the National Board of ... to going above and beyond in his pursuit of providing the most comprehensive, ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority ... announced that Charles W. Stellar has been named by the WEDI Board of Directors ... 2016. As an executive leader with more than 35 years of experience in healthcare, ...
(Date:5/24/2016)... Mass. (PRWEB) , ... May 24, 2016 , ... ... heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester ... cells into engines of wound healing and tissue regeneration. , The novel method, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Media ... The new Media Cybernetics corporate branding reflects a results-driven revitalization for a company ... analysis. The re-branding components include a crisp, refreshed logo and a new web ...
Breaking Biology Technology: