Navigation Links
Bacterial DNA may integrate into human genome more readily in tumor tissue
Date:6/20/2013

Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, according to a new study from the University of Maryland School of Medicine's Institute for Genome Sciences. Researchers analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas (TCGA). They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in the absence of sex.

Scientists have already shown that bacteria can transfer DNA to the genome of an animal. The researchers at the University of Maryland Institute for Genome Sciences found evidence that lateral gene transfer is possible from bacteria to the cells of the human body, known as human somatic cells. They found the bacterial DNA was more likely to integrate in the genome in tumor samples than in normal, healthy somatic cells. The phenomenon might play a role in cancer and other diseases associated with DNA damage. The paper was published in PLOS Computational Biology on June 20.

"LGT from bacteria to animals was only described recently, and it is exciting to find that such transfers can be found in the genome of human somatic cells and particularly in cancer genomes," says Julie C. Dunning Hotopp, Ph.D., Assistant Professor of Microbiology and Immunology at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine and lead author on the paper. Dr. Hotopp also is a research scientist with the University of Maryland Marlene and Stewart Greenebaum Cancer Center. "Studies applying this approach to additional cancer genome projects could be fruitful, leading us to a better understanding of the mechanisms of cancer."

In the research, a team of interdisciplinary scientists and bioinformatics researchers found that while only 63.5% of TCGA samples analyzed were from tumors, the tumor samples contained 99.9% of reads supp
'/>"/>

Contact: Karen Robinson
karobinson@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bacterial shock to recapture essential phosphate
2. Researchers develop rapid test strips for bacterial contamination in swimming water
3. The activity of a bacterial effector protein seen in molecular detail
4. More than 1 way to be healthy: Map of bacterial makeup of humans reveals microbial rare biosphere
5. Consortium of scientists maps the human bodys bacterial ecosystem
6. Normal bacterial makeup has huge implications for health, says CU professor
7. Programmable DNA scissors found for bacterial immune system
8. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
9. Innate immune system protein provides a new target in war against bacterial infections
10. Toward an alternative for antibiotics to fight bacterial infections?
11. Cystic fibrosis makes airways more acidic, reduces bacterial killing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a ... Funding for this $50 million capital project is part ... launched next summer. The medical education ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in ... plans to be ready to welcome medical students in ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... a unique vulnerability that can be exploited to make ... Washington University School of Medicine in St. Louis report. ... that tumors have a built-in mechanism that protects them ... benefit of hyperthermia and radiation as a combined therapy. ...
... way to rejuvenate dead nerve endings and a device ... among this years nine winners at NJITs annual provosts ... I walk through this showcase is the sophisticated array ... undergraduate students, said NJIT Provost Priscilla P. Nelson. ...
... the US, many people believe that the recent proliferation of ... people aim to significantly reduce the amount of saturated fats ... healthier, and happier. However, many leading researchers in the medical ... In FAT: ITS NOT WHAT YOU THINK (Prometheus, $15.95), technical ...
Cached Biology News:Researchers find way to make tumor cells easier to destroy 2NJIT applauds students for studies on brain injury, glaucoma and more 2Fat: Its not what you think! 2
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
(Date:12/22/2014)... 2014  Alternative Energy & Environmental Solutions, Inc., ... a letter of intent to acquire BioTechPharma Corporation, ... a nanotechnology-based development platform used to create drug ... on-site collection and testing to identify infectious disease, ... an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... 2014 ITRA Global, one of the ... commercial real estate, has further expanded its global reach ... and Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman ... ITRA Global / ACORPP (Australian Corporate Property and Projects) ... providing property services to a wide range of clients ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... 19 The 2009 Frost & Sullivan European ... Xenometrix AG in recognition of its active role ... cytotoxicity assays. (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )These test ... drug discovery, improve the effectiveness of drug discovery ...
... sail to Baltic, Black and Mediterranean Seas, sampling ... local San Diego supporters Beyster Family Foundation Fund ... DIEGO, March 18, The J. Craig Venter ... new Sorcerer II Expedition--the J. Robert Beyster and ...
... Pharmatech Oncology has been selected by the Fitzsimons ... Colorado Science + Technology Park at Fitzsimons. The ... companies. The majority of the companies are in ... expanding their research on commercial products. Pharmatech Oncology ...
Cached Biology Technology:Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 2Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 2Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 4Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 5The Fitzsimons Redevelopment Authority Selects Pharmatech Oncology as Preferred Vendor 2
... 384 Round Well ... Thermo Labsystems wide range ... ideal for high-throughput screening ... miniaturization of assays and ...
HLA-DRbeta (DA2)...
...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Biology Products: