Navigation Links
Bacterial DNA may integrate into human genome more readily in tumor tissue
Date:6/20/2013

Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, according to a new study from the University of Maryland School of Medicine's Institute for Genome Sciences. Researchers analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas (TCGA). They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in the absence of sex.

Scientists have already shown that bacteria can transfer DNA to the genome of an animal. The researchers at the University of Maryland Institute for Genome Sciences found evidence that lateral gene transfer is possible from bacteria to the cells of the human body, known as human somatic cells. They found the bacterial DNA was more likely to integrate in the genome in tumor samples than in normal, healthy somatic cells. The phenomenon might play a role in cancer and other diseases associated with DNA damage. The paper was published in PLOS Computational Biology on June 20.

"LGT from bacteria to animals was only described recently, and it is exciting to find that such transfers can be found in the genome of human somatic cells and particularly in cancer genomes," says Julie C. Dunning Hotopp, Ph.D., Assistant Professor of Microbiology and Immunology at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine and lead author on the paper. Dr. Hotopp also is a research scientist with the University of Maryland Marlene and Stewart Greenebaum Cancer Center. "Studies applying this approach to additional cancer genome projects could be fruitful, leading us to a better understanding of the mechanisms of cancer."

In the research, a team of interdisciplinary scientists and bioinformatics researchers found that while only 63.5% of TCGA samples analyzed were from tumors, the tumor samples contained 99.9% of reads supp
'/>"/>

Contact: Karen Robinson
karobinson@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bacterial shock to recapture essential phosphate
2. Researchers develop rapid test strips for bacterial contamination in swimming water
3. The activity of a bacterial effector protein seen in molecular detail
4. More than 1 way to be healthy: Map of bacterial makeup of humans reveals microbial rare biosphere
5. Consortium of scientists maps the human bodys bacterial ecosystem
6. Normal bacterial makeup has huge implications for health, says CU professor
7. Programmable DNA scissors found for bacterial immune system
8. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
9. Innate immune system protein provides a new target in war against bacterial infections
10. Toward an alternative for antibiotics to fight bacterial infections?
11. Cystic fibrosis makes airways more acidic, reduces bacterial killing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... HILDEN, Germany , June 17, 2015 /PRNewswire/ ... Prime Standard: QIA) today launched new Investigator ® STR ... in the United States . The new ... multiple key genomic markers (short tandem repeats or STRs) for ... to evaluate the quality of DNA in each sample, a ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - handyem ... centralized around the incorporation of handyem,s HPC-150 portable ... laboratory, the Mo-POD™. This unprecedented model of mobile ... Conference at the Pennsylvania ... June 15 th to 18 th ...
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... communicated that it will amount to at least 340 MSEK ... to the rapid increase in market growth and orders received ... communicated guidance that revenue for 2015 will exceed 1,500 MSEK ... to approximately 2,200 MSEK. Due to receipt of ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... new and notable article entitled Passage Times for ... Volume 94, Issue 5, of the Biophysical Journal, which ... for Polymer Translocation Pulled through a Narrow Pore ... in membranes, in a process known as translocation, they ...
... London (March 10, 2008) King Abdullah University ... London today announced their partnership in KAUSTs Academic ... research , collaborate in the design of the academic ... chemical engineering and materials science and engineering for the ...
... new light on a novel histone acetyltransferase protein complex ... acetyl functional group into histone proteins, a process by ... findings were posted to the Web site of Nature ... a future print edition of the journal. ...
Cached Biology News:Media highlights for February in Biophysical Journal 2KAUST announces academic excellence alliance partnership with Imperial College London 2Workman Lab characterizes novel regulator of chromosome function 2
(Date:7/1/2015)... ... , ... Apex Therapeutics announced today that company CEO, David Broecker provided a ... The presentation took place on Tuesday, June 16 and provided an update on the ... the treatment of pancreatic cancer. A copy of the company overview can be ...
(Date:7/1/2015)... 1, 2015  UCB, a multinational biopharmaceutical company, ... leader in designing, transforming, and running intelligent business ... recognition of their close collaboration in driving transformation ... business services (GBS) finance organization. The ... that work together effectively to embrace the innovative ...
(Date:6/30/2015)... ... June 30, 2015 , ... Students and ... in the first half of “Integrative Biotechnology,” an applied biotechnology course team-taught by ... 2014, this course combines students from both universities and is taught on both ...
(Date:6/30/2015)... ... June 30, 2015 , ... Park Systems ... advanced scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize ... 'the wonder material of the 21st Century' by the researchers who were awarded ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4
... 2011 To assist U.S. employers in understanding and ... implications of health reform, The Vitality Group , ... paper. The information is publicly available and can be ... (Logo:   http://photos.prnewswire.com/prnh/20110713/CG34519LOGO ) This paper ...
... 2011 Reportlinker.com announces that a new ... catalogue: Industrial Biotechnology China ... In this issue, we ... regulation about biofuel, which include "Instruction for ...
... July 12, 2011 Comprendia, leading developer of ... life sciences, sponsored by molecular biology reagents provider ... online resource that will support epigenetics research. Epigenetics ... for oncology, neurology, metabolism and disease mechanisms.  ,Engaging ...
Cached Biology Technology:The Vitality Group Helps U.S. Businesses Navigate New Legal Environment for Health and Wellness Programs 2Industrial Biotechnology China News 1106 2Industrial Biotechnology China News 1106 3Industrial Biotechnology China News 1106 4Comprendia and New England Biolabs Connect Epigenetics Scientists with New Social Media Application 2Comprendia and New England Biolabs Connect Epigenetics Scientists with New Social Media Application 3
Raised to 5-HIAA coupled to BSA with paraformaldehyde....
Immunofixation Gel Kit, requires IF100 Reactivity: Human Applications: Immunofixation ...
The 50 ml Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: four 50 ml tubes. ,Magnets: Neodymium rare earth permanent magnets....
...
Biology Products: