Navigation Links
Bacteria use lethal cytotoxins to evade antibiotic treatment
Date:11/18/2013

In spite of the fact that the first antibiotics were discovered almost a century ago, infectious diseases such as tuberculosis, encephalitis and meningitis are still serious diseases for humans in the twenty-first century. The World Health Organization (WHO) estimates that there are more than 8 million new cases of tuberculosis per year on a global scale, and that more than 300,000 of these are due to multidrug-resistant strains that are not only difficult to treat, but are also emerging rapidly in regions such as Eastern Europe.

Bacterial tolerance is not just due to resistance, but also to the formation of persistent cells that have gone into a dormant state where they are no longer sensitive to antibiotics. On the molecular level, this process is controlled by a number of advanced cytotoxins produced by the bacteria themselves in order to survive. In Mycobacterium tuberculosis the organism that causes tuberculosis there are no fewer than 88 such toxins, all of which presumably help the organism to survive.

In a new article in the renowned journal Nature Communications, an international team of researchers with the participation of the Department of Molecular Biology and Genetics, Aarhus University, has revealed the mechanism behind one of these toxins VapC20. It turns out that when the toxin is activated, it destroys the tuberculosis bacteria's own protein 'factory' (the ribosome) by cleavage. The bacteria are thereby unable to produce proteins in the short term, and thus avoid the effect of antibiotics that also often attack the ribosome.

When treatment with antibiotics is completed, the pathogenic bacteria 'wake up' and are ready to synthesise new ribosomes. Surprisingly, it appears that the location in the ribosome that is cleaved by VapC20 is the same place that is destroyed by the strong cytotoxins α-sarcin and ricin, which are found in plants such as castor beans and are twice as venomous as cobra snake poi
'/>"/>

Contact: Ditlev E. Brodersen
deb@mb.au.dk
45-21-66-90-01
Aarhus University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacteria use lethal cytotoxins to evade antibiotic treatment
(Date:11/18/2014)... --  News Highlights: , ... Partners Data Lake, an agile data and analytics ... allow researcher and clinicians to explore and develop ... of patients , The Partners Data Lake ... Partners system, breaking down physical barriers for collaboration ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a leading ... its U.are.U ® fingerprint readers have been deployed ... Central Mexico . The bakery chain ... eliminate payroll issues caused by employees clocking in for ... U.are.U fingerprint readers, Montparnasse relied on paper timecards and ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... a chronic swelling condition that can appear after ... million breast cancer survivors. Although lymphedema can cause ... chest, there is no national standard of diagnosis ... leading the American Lymphedema Framework Project (ALFP), a ...
... On the first anniversary of the American Recovery ... the nation,s research universities today provided nearly 100 examples ... is paying outsize short- and long-term dividends for the ... ARRA, $21.5 billion is allocated for research and science ...
... State University graduate students teaching introductory biology labs are ... engage their students in critical thinking, and even craft ... a Graduate Teacher Training Program supported by a portion ... university has received. The training program is operated by ...
Cached Biology News:Researchers develop standard of care for breast cancer survivors with lymphedema 2Universities highlight benefits of stimulus research funding 2Universities highlight benefits of stimulus research funding 3Oregon State trains graduate students to be better TAs 2Oregon State trains graduate students to be better TAs 3Oregon State trains graduate students to be better TAs 4
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... centers, announced today that applications for AccelerateBaltimore™ (AB) ... “Do you have a big idea?,” asked ETC’s ... know about it. AccelerateBaltimore helps you and your ... just 13 weeks.” Interested game changers with ...
(Date:11/26/2014)... November 25, 2014 SonaCare Medical, ... Ultrasound (HIFU) devices, recently participated in the American ... Mass 360° .” Key opinion leaders in urology ... related to small renal masses while attendees had ... ablative technologies in hands-on labs. Attendees at the ...
(Date:11/26/2014)... The Pittcon marketing department is pleased to announce ... app, Pittcon 2015 . The ... for iOS and Android devices and the Kindle Fire, ... after the event. It acts as an all-inclusive real-time ... Conferee Networking sessions and short courses. , The Pittcon ...
(Date:11/26/2014)... 26, 2014 SoundConnect , an ... proud to announce that Darren Suders has joined the ... Darren will drive the partner program through ... , Darren brings more than 10-years of ... roles in channel operations, from policy development, to partner ...
Breaking Biology Technology:AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2SoundConnect Appoints Director of Channel Development & Sales 2
... April 2 SPO Medical Inc. (OTC: SPOM),a leading ... monitoring devices, announced today that it has filed its ... 31, 2008. , Gross revenues ... revenues,reflect initial sales of SPO Medical,s finger oximeter PulseOx ...
... Biovista Inc. today,announced that BVA-101, its drug targeting ... the MOG-induced Experimental Allergic,Encephalomyelitis (EAE) murine model of ... MS and is aimed at neuroprotection, was shown ... toxic effects in this well,established model of MS. ...
... April 2 Chimerix, Inc., a biotechnology company ... the Company has joined the Medicines for Malaria ... to discover, develop and facilitate the delivery of ... will screen Chimerix, chemical library to identify activity ...
Cached Biology Technology:SPO Medical Files Annual Report for Fiscal 2008 2SPO Medical Files Annual Report for Fiscal 2008 3Biovista Inc. Announces Positive Efficacy Results in a Pre-Clinical Trial of its BVA-101 Repositioned Drug for Multiple Sclerosis 2Chimerix Joins International Network of Organizations to Cure Malaria 2Chimerix Joins International Network of Organizations to Cure Malaria 3
Cells are grown in triple flasks or roller bottles. Viability and growth data are generated from a parallel representative culture....
... Human Genetic Cell Bank Service The ... based on Epstein-Barr Virus (EBV) immortalisation of ... the production of lymphoblastoid cell lines (LCLs). ... a renewable and expandable source of genomic ...
... are optimized for maximum packaging efficiencies of ... efficiency extracts (> 109 pfu/g with control ... library containing at least 5 107 ... are made from a specially designed phage ...
... has 20 years of expertise in the ... still offers the most powerful systems on ... to 40 000 in-microplate tests requiring incubation ... of different modules (such as worktable shaker ...
Biology Products: