Navigation Links
Bacteria use lethal cytotoxins to evade antibiotic treatment
Date:11/18/2013

In spite of the fact that the first antibiotics were discovered almost a century ago, infectious diseases such as tuberculosis, encephalitis and meningitis are still serious diseases for humans in the twenty-first century. The World Health Organization (WHO) estimates that there are more than 8 million new cases of tuberculosis per year on a global scale, and that more than 300,000 of these are due to multidrug-resistant strains that are not only difficult to treat, but are also emerging rapidly in regions such as Eastern Europe.

Bacterial tolerance is not just due to resistance, but also to the formation of persistent cells that have gone into a dormant state where they are no longer sensitive to antibiotics. On the molecular level, this process is controlled by a number of advanced cytotoxins produced by the bacteria themselves in order to survive. In Mycobacterium tuberculosis the organism that causes tuberculosis there are no fewer than 88 such toxins, all of which presumably help the organism to survive.

In a new article in the renowned journal Nature Communications, an international team of researchers with the participation of the Department of Molecular Biology and Genetics, Aarhus University, has revealed the mechanism behind one of these toxins VapC20. It turns out that when the toxin is activated, it destroys the tuberculosis bacteria's own protein 'factory' (the ribosome) by cleavage. The bacteria are thereby unable to produce proteins in the short term, and thus avoid the effect of antibiotics that also often attack the ribosome.

When treatment with antibiotics is completed, the pathogenic bacteria 'wake up' and are ready to synthesise new ribosomes. Surprisingly, it appears that the location in the ribosome that is cleaved by VapC20 is the same place that is destroyed by the strong cytotoxins α-sarcin and ricin, which are found in plants such as castor beans and are twice as venomous as cobra snake poi
'/>"/>

Contact: Ditlev E. Brodersen
deb@mb.au.dk
45-21-66-90-01
Aarhus University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacteria use lethal cytotoxins to evade antibiotic treatment
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. ... human interface solutions, today announced that four of ... Match-in-Sensor solution, have officially been named FIDO Certified™ ... part of the certification, Synaptics, Natural ID™ fingerprint ... Universal Authentication Framework (UAF) standard and are interoperable ...
(Date:8/6/2015)... and TELTOW, Germany , ... 2015 Siggraph Conference, SensoMotoric Instruments (SMI) shows ... reality , based on Epson,s Moverio BT-200 ... tracking platform. With this new solution, unprecedented quality and ... hands-free interaction with context-sensitive displays. For the first time, ...
(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
Breaking Biology News(10 mins):Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... Walter Leal, professor of entomology at the University ... a major award from the Entomological Society of ... Biochemistry and Toxicology. Leal, former chair of ... his innovative and creative research involving insect communication. ...
... and metal rods to complex virtual humans made of muscle, ... evolving and researchers at Wake Forest University School of Medicine ... new generation of human body models will represent live humans ... The models will contain detailed representation of the bones and ...
... be smarter than we thought. Faced with a dire shortage ... may be able to cross-breed with certain other coral species ... This finding, released by scientists at the ARC Centre ... the ability of the world,s corals to withstand the rigors ...
Cached Biology News:UC Davis chemical ecologist wins major award 2Wake Forest plays integral role in effort to revolutionize vehicle safety 2Wake Forest plays integral role in effort to revolutionize vehicle safety 3Rare corals breed their way out of trouble 2
(Date:8/31/2015)... , Aug. 31, 2015 FLX Bio, ... development of novel cancer immunotherapies, announced today that it ... Chief Executive Officer and William Ho , M.D., ... join an experienced management team led by veterans of ... , Ph.D., Chief Scientific Officer; Jay Powers , ...
(Date:8/31/2015)... ... 2015 , ... There’s a new treatment option for excessive menstrual bleeding – ... FDA approved system in the last 14 years, and the only endometrial ablation product ... rate of 66%, the high Patient Satisfaction rate of 98%, and the fastest procedure ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... Medicine, presented two studies at the International Spine Intervention Society’ s ... 2015 through to August 1st, 2015. With a focus on evidence-based research and ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... for venture capital funds, investment firms and animal health companies to hear from ... raised $160 million. Several have also received licensing agreements or distribution contracts. ...
Breaking Biology Technology:FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3
... Royalty LP 2 (DRC) announced,today the purchase of ... in PEG-INTRON for $92.5M. DRC will also provide ... recognition levels be met.,PEG-INTRON (peginterferon alpha-2b), is approved ... worldwide by Schering-Plough Corporation (SGP). Speaking on ...
... YORK, Aug. 27 The American Stock Exchange(R),(Amex(R)) ... under the ticker,symbol CUR. Neuralstem, Inc. is ... neural stem cell technology in the field of,regenerative ... American Stock Exchange," said,John McGonegal, Senior Vice President ...
... LANSING, Mich., Aug. 27 Neogen Corporation,(Nasdaq: ... leading manufacturer,and marketer of animal health products. ... products through a,network of more than 200 distributors ... products of exceptional quality, including its,well-regarded AG-TEK(R) veterinary ...
Cached Biology Technology:Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN) 2Neogen Acquires Kane Enterprises 2
... TProfessional Thermocycler combines top performance with exquisite ... high speed and unparalleled temperature uniformity. The ... programming in a spreadsheet or alternatively in ... Lid opens on the push of a ...
Preparation TW--Compatibility: no end cap seals -Hybridization Tube for Hybrigene -Comp Dim: 240 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-15...
... is Tecans state-of-the-art software for all your ... scheduling in a single, scalable software package. ... consistent, simplifying the control of all Freedom ... Freedom EVO 100 with one liquid handling ...
... Vesicles Isolation Kit provides all the ... synaptic vesicle fraction. The isolation procedure ... the synaptosomes, and differential centrifugation followed ... kit also contains an antibody specific ...
Biology Products: