Navigation Links
Bacteria that cause urinary tract infections invade bladder cells
Date:12/17/2007

St. Louis, Dec. 17, 2007 Scientists at Washington University School of Medicine in St. Louis have found definitive proof that some of the bacteria that plague women with urinary tract infections (UTIs) are entrenched inside human bladder cells.

The finding confirms a controversial revision of scientists' model of how bacteria cause UTIs. Previously, most researchers assumed that the bacteria responsible for infections get into the bladder but do not invade the individual cells that line the interior of the bladder.

"Our animal model of UTIs has allowed us to make a number of predictions about human UTIs, but at the end of the day, we felt it was critical to show this in humans, and now we've done just that," says senior author Scott J. Hultgren, Ph.D., the Helen L. Stoever Professor of Molecular Microbiology at the School of Medicine.

The results appear in the December issue of Public Library of Science Medicine.

Fully understanding what bacteria do in the bladder is critical to developing better diagnoses and treatments for UTIs, Hultgren says. The bacterium Escherchia coli is thought to be responsible for 80 percent to 90 percent of UTIs, which occur mainly in women and are one of the most common bacterial infections in the United States. Scientists estimate that more than half of all women will experience a UTI in their lifetimes, and recurrent UTIs will affect 20 percent to 40 percent of those patients.

"Recurrence is one of the biggest problems of UTIs," says Hultgren. "Even though we have treatments that eliminate the acute symptoms, the fact that the disease keeps recurring in so many women tells me that we need to develop better treatments."

Prior to the work of Hultgren and his colleagues, most microbiologists and urologists believed for a variety of reasons that E. coli wasn't getting into bladder cells.

"For example, there is a barrier in the bladder that prevents toxins and other things
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Shuttle brings space-grown strep bacteria back for study
2. The worlds oldest bacteria
3. Bacteria from sponges make new pharmaceuticals
4. Boston University biomedical engineers find chink in bacterias armor
5. University of Leicester scientists discover technique to help friendly bacteria
6. Spaceflight shown to alter ability of bacteria to cause disease
7. A tiny pinch from a z-ring helps bacteria cells divide
8. Legionnaires bacterial proteins work together to survive
9. Scripps research team blocks bacterial communication system to prevent deadly staph infections
10. NSF awards Stevens team $1 million for research on smart, bacteria-repellent nanohydrogels
11. Chemical compound present in detergents produce bacteria alterations in agricultural soils
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... The Microbial Diversity Course at the Marine Biological ... a Milestones in Microbiology site by the American ... in Microbiology program recognizes institutions and the scientists ... toward advancing the science of microbiology. A ... site is scheduled for Saturday, June 22, 2013, ...
(Date:6/19/2013)... , June 19, 2013 MedNet Solutions ... clinical study management systems, is pleased to announce its ... held June 23-27 in Boston . ... a recognized leader in cloud-based eClinical solutions, has exhibited ... be showcasing iMedNet™ EDC , MedNet,s ...
(Date:6/19/2013)... 19, 2013  New York College of Health Professions ... Patent and Trademark Office for detecting biometric changes through ... guards have been injured, attacked or killed. ... the Intellectual Properties Agreements of New York College of ... of New York College says, ...
Breaking Biology News(10 mins):Microbial diversity course designated as a 'Milestones in Microbiology' site 2MedNet Solutions To Spotlight iMedNet EDC At The 49th DIA Annual Meeting 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 3New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 4
... from Huntsman Cancer Institute (HCI) at the University ... to identify cancer-causing rearrangements of genetic material called ... of the method and the research results appear ... Molecular Medicine journal. Many cancers result from ...
... diseases might soon have another warrior to contend with, thanks ... of Illinois. The new antibiotic, an analog of the widely ... boon to the dairy industry as a treatment for bovine ... product of bacteria resident in the cow,s udder. It helps ...
... may have discovered how memories are encoded in ... strengthened synaptic connections among neurons. However components of ... while memories can last a lifetime. Based ... lead researcher Jack Tuszynski, his graduate student Travis ...
Cached Biology News:Beyond the microscope: Identifying specific cancers using molecular analysis 2New antibiotic could make food safer and cows healthier 2New antibiotic could make food safer and cows healthier 3
(Date:6/19/2013)... Bellevue city councilmember John Stokes will ... for people with disabilities on Friday, June 21 ... , The exhibit hall, which is free and ... will feature leading manufacturers and suppliers of assistive ... technologies, computer applications, and home modification equipment. Local ...
(Date:6/19/2013)... , June 19, 2013  U.S. Secretary of ... ceremony at which distinguished Syngenta  scientist Mary-Dell ... prestigious 2013 World Food Prize. The prize is the ... development by improving the quality, quantity or availability of ... two other laureates were recognized for "revolutionary biotechnology discoveries ...
(Date:6/19/2013)... Clinverse, Inc. , a ... trials, today announced it will be exhibiting and ... in Boston, June 24-26, 2013. Clinverse’s eClinical ... fully configurable, cloud-based clinical financial lifecycle system. , ... Clinverse’s eClinical Commerce Network, automates site contract set-up ...
(Date:6/19/2013)... , June 19, 2013 MO BIO ... and other challenging microbial nucleic acid purification, announces ... Kit, for extraction of pure protein from all ... coincides with the 20 th anniversary of ... capabilities. (Photo: http://photos.prnewswire.com/prnh/20130619/LA32633 ) ...
Breaking Biology Technology:City of Bellevue, Wash., Welcomes Assistive Technology Exhibit Hall 2Syngenta's Mary-Dell Chilton named 2013 World Food Prize laureate 2Clinverse, Inc. Exhibiting and Showcasing Its Technology at DIA 2013 2MO BIO Laboratories, Inc. launches the first kit for protein extraction from soil 2
... K. H. Valkonen*, N. Marttinen*, H.-L. Malinen*, V.-P. Jaakola** and , ... , * Biotechnology Laboratory, REDEC of Kajaani, University ... ** Department of Biological and Environmental Science, University of Jyvskyl, , ... , Introduction , ...
... Contributed by Philip W Miller, Waltraud I Dunn, and Robert R Schmidt, , ... FL 32611 USA , ... , Introduction , ... elucidate the pre- , and posttranslational mechanisms that regulate ...
... Introduction , ... or probes in genetic analysis. Quality control of these preparations ... electrophoresis or HPLC, but these , methods may ... not provide desired quantitative precision or automation. Capillary electrophorsis , ...
Cached Biology Technology:Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 2Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 3Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 4Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 5Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 6Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 7Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 8Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 9Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 10Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 11Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 12Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B 2Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B 3Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B 4Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B 5Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B 6Oligonucleotide Purity Analysis by Capillary Electrophoresis 2Oligonucleotide Purity Analysis by Capillary Electrophoresis 3
Purified anti-PXR...
Request Info...
Mouse monoclonal [2991] to C3a / C3a des Arg ( Abpromise for all tested applications). SwissProtID: P01024...
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Biology Products: