Navigation Links
Bacteria possible cause of preterm births
Date:1/27/2011

The type of bacteria that colonize the placenta during pregnancy could be associated with preterm birth and other developmental problems in newborns according to research published in the current issue of the online journal mBio.

"The fetal inflammatory response appears to contribute to the onset of preterm labor, fetal injury and complications, underlying lifetime health challenges facing these children," say the researchers from Harvard Medical School, Brigham and Women's Hospital and Children's Hospital of Boston. "Our data suggest that placental colonization by specific groups of organisms can increase or decrease the risk of a systemic inflammatory condition."

Preterm birth occurs in nearly a half million pregnancies in the United States alone. Despite improved care, preterm and especially extremely low-gestational-age newborns continue to be at a considerably higher risk of morbidity, mortality and developmental problems. Much of this risk is attributable to imbalanced inflammatory responses of the fetus and newborn.

The systemic fetal inflammatory response to intrauterine exposures, especially intrauterine infections, is regarded as an important contributor to the onset and often lifelong consequences of preterm labor, fetal injury and early organ damage. Approximately half of all placentas delivered before the second trimester and 41% of those delivered by Caesarean section harbor microorganisms detectable by culture techniques.

In order to better understand what role, these microorganisms could play in the extremely preterm inflammatory response the researchers analyzed protein biomarkers in dry blood spots obtained from 527 newborns delivered by Caesarean section and cultured and identified the bacteria from their respective placentas.

Placentas colonized primarily by microorganisms commonly associated with the condition know as bacterial vaginosis (BV) were found to be associated with elevated levels of proinflammatory protein in newborns. In contrast, colonization by Lactobacillus species of bacteria (often found in decreased concentrations during BV) were associated with lower levels of proinflammatory proteins.

"Our study supports the concept that the placental colonization with vaginal microorganisms can induce a systemic inflammatory response in the fetus and newborn and that the dominating molecular feature of this response can be dependent on the type of bacteria," says Andrew Onderdonk of Harvard Medical School and Brigham and Women's Hospital, one of the authors of the study. "Our data suggest that the targeting of placental colonization by specific drugs or probiotics during early pregnancy may hold promise for preventing not only preterm birth but also the devastating and far-reaching inflammatory consequences in premature newborns."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Food-borne bacteria causes potentially fatal heart infection
2. New method attacks bacterial infections on contact lenses
3. The genius of bacteria
4. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
5. Defense mechanism against bacteria and fungi deciphered
6. The good, the bad and the green -- harnessing the potential of bacteria
7. A pesky bacterial slime reveals its survival secrets
8. Probiotics, prebiotics and biofuel-producing bacteria
9. Pitt study finds green water treatments may not kill bacteria in large building cooling systems
10. UCSF team develops logic gates to program bacteria as computers
11. Eutrophication makes toxic cyanobacteria more toxic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... NEW YORK , April 20, 2017 ... industry that focuses on novel drug development and clinical research ... morning are: Biostage Inc. (NASDAQ: BSTG), Keryx Biopharmaceuticals Inc. (NASDAQ: ... (NASDAQ: ZIOP ). You can access our complimentary ... ...
(Date:4/19/2017)... ... April 18, 2017 , ... Alisa Wright, founder and ... Awards from the Purdue College of Pharmacy in Lafayette, Indiana. , The Distinguished ... for achievements in their careers and other scientific endeavors. , Wright began her ...
(Date:4/19/2017)... ... April 19, 2017 , ... ... financing round. This event adds to several other early achievements at ThermaGenix, including ... Scientific Teams. , ThermaGenix will use proceeds from the Series A-1 ...
(Date:4/19/2017)... and PUNE, India , April 19, 2017 ... Microfiltration Market: Global Opportunity Analysis and Industry Forecast, 2014-2022 ," the global market ... million by 2022, registering a CAGR of 9.6% from 2016 to 2022. ... ... ...
Breaking Biology Technology: