Navigation Links
Bacteria possible cause of preterm births
Date:1/27/2011

The type of bacteria that colonize the placenta during pregnancy could be associated with preterm birth and other developmental problems in newborns according to research published in the current issue of the online journal mBio.

"The fetal inflammatory response appears to contribute to the onset of preterm labor, fetal injury and complications, underlying lifetime health challenges facing these children," say the researchers from Harvard Medical School, Brigham and Women's Hospital and Children's Hospital of Boston. "Our data suggest that placental colonization by specific groups of organisms can increase or decrease the risk of a systemic inflammatory condition."

Preterm birth occurs in nearly a half million pregnancies in the United States alone. Despite improved care, preterm and especially extremely low-gestational-age newborns continue to be at a considerably higher risk of morbidity, mortality and developmental problems. Much of this risk is attributable to imbalanced inflammatory responses of the fetus and newborn.

The systemic fetal inflammatory response to intrauterine exposures, especially intrauterine infections, is regarded as an important contributor to the onset and often lifelong consequences of preterm labor, fetal injury and early organ damage. Approximately half of all placentas delivered before the second trimester and 41% of those delivered by Caesarean section harbor microorganisms detectable by culture techniques.

In order to better understand what role, these microorganisms could play in the extremely preterm inflammatory response the researchers analyzed protein biomarkers in dry blood spots obtained from 527 newborns delivered by Caesarean section and cultured and identified the bacteria from their respective placentas.

Placentas colonized primarily by microorganisms commonly associated with the condition know as bacterial vaginosis (BV) were found to be associated with elevated levels of proinflammatory protein in newborns. In contrast, colonization by Lactobacillus species of bacteria (often found in decreased concentrations during BV) were associated with lower levels of proinflammatory proteins.

"Our study supports the concept that the placental colonization with vaginal microorganisms can induce a systemic inflammatory response in the fetus and newborn and that the dominating molecular feature of this response can be dependent on the type of bacteria," says Andrew Onderdonk of Harvard Medical School and Brigham and Women's Hospital, one of the authors of the study. "Our data suggest that the targeting of placental colonization by specific drugs or probiotics during early pregnancy may hold promise for preventing not only preterm birth but also the devastating and far-reaching inflammatory consequences in premature newborns."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Food-borne bacteria causes potentially fatal heart infection
2. New method attacks bacterial infections on contact lenses
3. The genius of bacteria
4. 2 bacterial enzymes confer resistanceto common herbicide, say MU researchers
5. Defense mechanism against bacteria and fungi deciphered
6. The good, the bad and the green -- harnessing the potential of bacteria
7. A pesky bacterial slime reveals its survival secrets
8. Probiotics, prebiotics and biofuel-producing bacteria
9. Pitt study finds green water treatments may not kill bacteria in large building cooling systems
10. UCSF team develops logic gates to program bacteria as computers
11. Eutrophication makes toxic cyanobacteria more toxic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking ... Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity as ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
(Date:6/23/2016)... , June 23, 2016 ... market research report to its pharmaceuticals section with ... product details and much more. Complete ... across 151 pages, profiling 15 companies and supported ... at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The ...
Breaking Biology Technology: