Navigation Links
Bacteria play role in preventing spread of malaria
Date:5/8/2009

Bacteria in the gut of the Anopheles gambiae mosquito inhibit infection of the insect with Plasmodium falciparum, the parasite that causes malaria in humans, according to researchers at the Johns Hopkins Bloomberg School of Public Health. Scientists with the Bloomberg School's Malaria Research Institute found that removing these bacteria, or microbial flora, with antibiotics made the mosquitoes more susceptible to Plasmodium infection because of a lack of immune stimulation. Their study is published in the May 8, 2009, edition of the journal PLoS Pathogens.

As part of the malaria transmission cycle, a mosquito acquires the malaria-causing parasite when it feeds on blood from an infected person. The parasite develops within the mosquito and can then be transmitted to another human when the mosquito feeds again.

"Our study suggests that the microbial flora of mosquitoes is stimulating immune activity that protects the mosquito from Plasmodium infection. The same immune factors that are needed to control the mosquito's infection from the microbes are also defending against the malaria parasite Plasmodium," said George Dimopoulos, PhD, senior author of the study and associate professor with Johns Hopkins Malaria Research Institute. "The interplay between bacteria and the mosquito's immune system may have significant implications for the transmission of malaria in the field where mosquitoes may be exposed to different types of bacteria in different regions. Theoretically, these bacteria could be introduced to the mosquitoes to boost their immunity to the malaria parasite and make them resistant and incapable of spreading the disease. Our current research aims at identifying those bacteria that trigger the strongest mosquito immune defense against the malaria parasite."

As part of the study, the Johns Hopkins researcher treated mosquitoes with antibiotics to kill the gut bacteria. Treated mosquitoes were more susceptible to infection by Plasmodium when feeding on infected blood compared to mosquitoes that were not treated with antibiotics. To further verify the results, bacteria-free mosquitoes were infected with bacteria to determine if they were less susceptible to Plasmodium infection.

In addition, the researchers determined that mosquitoes infected with bacteria died earlier than mosquitoes without bacteria when infected with Plasmodium; 60 percent of the mosquitoes with gut-bacteria died compared to 40 percent of those free of bacteriaeven with Plasmodium levels five times higher than those with bacteria.

"The malaria parasite must live in the mosquito for about two weeks in order to complete its life cycle and be transmitted to a person. The fact that these bacteria shorten the mosquito's life span is additional good news," said Dimopoulos.

Malaria kills over one million people worldwide each year; the majority of deaths are among children living in Africa.


'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Related biology news :

1. Tufted bacteria cause infection in premature babies
2. New study overturns orthodoxy on how macrophages kill bacteria
3. Details of bacterial injection system revealed
4. Sugar on bacteria surface serves as base for a web of resistance
5. Study finds multidrug-resistant gram-negative bacteria high in long-term care
6. Orientation of antenna protein in photosynthetic bacteria described
7. Researchers examine bacterial rice diseases, search for genetic solutions
8. Bad mix of bacterial remnants and genetics leads to arthritis
9. Corrosion-inhibiting coatings containing good bacteria
10. Genes that make bacteria make up their minds
11. Evolutionary origin of bacterial chromosomes revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016   Unisys Corporation (NYSE: ... John F. Kennedy (JFK) International Airport, New York City ... (CBP) identify imposters attempting to enter the United States ... to them. pilot testing of the system at ... three terminals at JFK during January 2016. --> pilot ...
(Date:1/22/2016)... Jan. 22, 2016 ... of the "Global Biometrics Market in ... offering. --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ...
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... significant achievements are the result of the company,s laser ... iMedNet eClinical , it,s comprehensive, easy-to-use and highly ... --> Key MedNet growth achievements in 2015 ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... 2016 Amarantus BioScience Holdings, Inc. ... on developing products for Regenerative Medicine, Neurology and Orphan ... Designation (RPDD) from the US Food and Drug Administration ... was previously granted orphan drug designation (ODD) by the ... BioScience Holdings, Inc. (OTCQB: AMBS), a ...
(Date:2/4/2016)... , Feb. 4, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... announced today that Edward Lanphier , Sangamo,s president ... the progress of Sangamo,s ZFP Therapeutic ® development ... at 2:40 pm ET on Thursday, February 11, 2016, ... Healthcare Conference. The conference is being held in ...
(Date:2/4/2016)... , Feb. 4, 2016  CytoSorbents Corporation (NASDAQ: ... commercializing its flagship CytoSorb® blood filter to treat ... around the world, announced that CEO Dr. ... the Source Capital Group,s 2016 Disruptive Growth & ... the company.  Conference Presentation Details: ...
(Date:2/4/2016)... BETHESDA, Md. , Feb. 4, 2016  Spherix ... committed to the fostering and monetization of intellectual property, ... VTech and Uniden in the Northern District of ... are moving forward.  Inter Partes ... the U.S. Patent Office.  The IPR was initiated on ...
Breaking Biology Technology: