Navigation Links
Bacteria 'launch a shield' to resist attack
Date:11/1/2009

Researchers from the University of Copenhagen and the Technical University of Denmark along with other collaborators in Denmark and the US found that the bacterium Pseudomonas aeruginosa can 'switch on' production of molecules that kill white blood cells preventing the bacteria being eliminated by the body's immune system.

P. aeruginosa is responsible for many hospital-acquired infections and also causes chronic infections in those with pre-existing medical conditions such as cystic fibrosis (CF). The bacteria cause persistent lung infections by clumping together to form a biofilm, which spreads over the lungs like a slime. Such biofilms are generally resistant to antibiotics as well as the host immune response.

The study showed that P. aeruginosa uses a well-studied communication system called quorum sensing (QS) to detect approaching white blood cells and warn other bacteria in the biofilm. In response to this signal, the bacteria increase their production of molecules called rhamnolipids. These molecules sit on the biofilm surface to form a shield that destroys any white blood cells that encounter it. Interrupting quorum sensing to halt the "launch a shield" response could be a way of treating these bacteria that can resist antibiotics as well as the host immune system.

Professor Michael Givskov from the University of Copenhagen who led the study believes there are significant clinical benefits to this research. "The ultimate goal [of this research] is to eradicate the present day's antibiotic-resistant bacteria that are involved in the bulk of chronic infections," he says. "Antibiotic resistance is one of the most serious emerging health problems in the world today. More than 70% of the disease-causing bacteria are resistant to at least one of the currently available antibiotics. Studying interactions between P. aeruginosa and the innate and adaptive immune response will provide valuable information for the design of novel antimicrobials".


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Boston University scientists first to see RNA network in live bacterial cells
2. Eating right, not supplements, is best at keeping your good bacteria healthy, dietitian says
3. Researchers discover RNA repair system in bacteria
4. Team finds a better way to watch bacteria swim
5. UT Knoxville and ORNL researchers reveal key to how bacteria clear mercury pollution
6. Taking sharper aim at stomach ulcer bacteria
7. Light, photosynthesis help bacteria invade fresh produce
8. Comprehensive understanding of bacteria could lead to new insights into many organisms
9. Yale engineers track bacterias kayak paddle-like motion for first time
10. Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells
11. U of C alumnus finds high numbers of heat-loving bacteria in cold Arctic Ocean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:4/24/2017)... April 24, 2017 Janice Kephart ... with  Identity Strategy Partners, LLP (IdSP) , today ... without President Trump,s March 6, 2017 Executive ... , refugee vetting can be instilled with greater confidence, ... now, all refugee applications are suspended by until ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... event entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, ... was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... providing advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience ... application consulting, Nanoscience Analytical offers a broad range of contract analysis services ...
Breaking Biology Technology: