Navigation Links
Bacteria-killing proteins cover blood type blind spot
Date:2/14/2010

A set of proteins found in our intestines can recognize and kill bacteria that have human blood type molecules on their surfaces, scientists at Emory University School of Medicine have discovered.

The results were published online Feb. 14 and are scheduled to appear in the journal Nature Medicine.

Many immune cells have receptors that respond to molecules on the surfaces of bacteria, but these proteins are different because they recognize structures found on our own cells, says senior author Richard D. Cummings, PhD, professor and chair of the Department of Biochemistry. "It's like having a platoon in an army whose sole purpose is to track down enemy soldiers that are wearing the home country's uniforms."

Blood type comes from differences in sugar molecules attached to proteins on red blood cells. If incompatible blood types are mixed, the antibodies from one person will make red blood cells from the other person clump together, with devastating results in an emergency. But someone's immune system usually doesn't make antibodies to the sugar molecules on his or her own red blood cells. That creates a potential blind spot that bacteria could exploit.

For example, a strain of E. coli (O86) has molecules on its surface like those in humans with blood type B. People with blood type B are unable to produce antibodies against E. coli O86. Although O86 is known to infect birds, it's not a major danger like other types of E. coli, some of which can cause severe diarrhea.

Cummings and his colleagues wanted to know why more bacteria haven't adopted the tactics of E. coli O86 to get around the immune system. Searching for proteins that could bind to the sugar molecules characteristic of blood types A and B, graduate students Sean Stowell, PhD, and Connie Arthur identified proteins called galectin-4 and galectin-8.

"These proteins are separate from antibodies and other parts of the immune system," Cummings says.
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
3. Depression, aging, and proteins made by a virus may all play role in heart disease
4. New approach builds better proteins inside a computer
5. Legionnaires bacterial proteins work together to survive
6. Proteins pack tighter in crowded native state
7. MIT IDs proteins key to brain function
8. Cystic fibrosis proteins photographed interacting
9. Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
10. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
11. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... Aware, Inc. (NASDAQ: AWRE ), a leading ... for its second quarter ended June 30, 2015.  ... million, a decrease of 33% compared to $6.8 million in ... quarter of 2015 was $0.3 million, or $0.01 per diluted ... share, in the same period a year ago.  ...
(Date:7/21/2015)... July 21, 2015 Passwords have proven ... in the recent U.S. Office of Personnel Management ... the infosec conundrum, but developers and end-users are ... address this dilemma, Biometrics-as-a-Service provider HYPR Corp. announced ... SDK for third party integration. ...
(Date:7/9/2015)... Calif. , July 9, 2015  Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... Thursday, July 30, 2015 after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... WASHINGTONA single, huge, violent storm that swept across the ... a new study shows. While storms have long ... study is the first to produce an actual body count. ... study,s authors say. This suggests that storms may play a ...
... world championship if we couldn,t distinguish the ball from its ... if your favourite team,s striker could see the movements of ... to flies. The minute brains of these aeronautic acrobats process ... the brain of the fly manages to perceive motion with ...
... 2010 Are online learning modules beneficial to educational ... learning modules to help increase participant understanding of key ... researchers found that participants both visited the sites on ... knowledge. Researchers at the University of Arizona, led ...
Cached Biology News:Staggering tree loss from 2005 Amazon storm 2Staggering tree loss from 2005 Amazon storm 3Staggering tree loss from 2005 Amazon storm 4The brain of the fly -- a high-speed computer 2The brain of the fly -- a high-speed computer 3The brain of the fly -- a high-speed computer 4Online learning supplements watershed program 2
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative ... study of its canine osteoarthritis stem cell product, currently under development for FDA ... and will be marketed in the US by Aratana. This product, termed AT-016, ...
(Date:7/30/2015)... , July 30, 2015  With over 60,000 customers across the globe, ISN improves ... 450 hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over ... Headquartered in Dallas, TX ...
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, Inc. ... has received the second $1.0M tranche under a ... (SBIR) grant valued at up to $3.0 million ... KL4 surfactant as a potential medical countermeasure to ... Labs was awarded an initial $1.0 million under ...
(Date:7/29/2015)... PARIS , July 30, 2015 ... leader, reports results for the second quarter of ... the group,s results and its performance in different ... transcript:  http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire ... - Q2 results - Performance drivers ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... Novavax, Inc. (Nasdaq: NVAX ) today announced ... a press release to be issued after 8:00 a.m. local ... investor conference call at 10:00 a.m. The call will be ... Singhvi and other members of senior management. The dial-in number ...
... NEW YORK, March 23, 2011 ... ACCP ), a biopharmaceutical company leveraging its ... oncology, cancer supportive care and diabetes, has ... Care and Market Access.  A 16-year industry veteran, Mottola ...
... made of carbon nanotubes dipped in a polymer solution equal ... cells, a team of Case Western Reserve University engineers has ... to boost the power output and maintain the other advantages ... But already they,ve proved the simple technique can knock ...
Cached Biology Technology:Access Pharmaceuticals Appoints Industry Executive Anthony Mottola as Vice President of Managed Care and Market Access 2Access Pharmaceuticals Appoints Industry Executive Anthony Mottola as Vice President of Managed Care and Market Access 3Cheap catalyst made easy 2
Plasmid expressing Zeocin resistance gene....
...
Hygromycin resistance gene (hph), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... FRT-PGK-gb2-neo-FRT template is designed to allow ... The FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin ... (gb2) for expression of kanamycin resistance in ... (PGK) for expression of neomycin resistance in ...
Biology Products: