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Bacteria hijack plentiful iron supply source to flourish
Date:7/9/2014

ian siderophore sources. That means that bacteria get the most iron."

Case Western Reserve researchers also demonstrated that the absence of mitochondrial siderophore in a mammal can enhance its ability to resist infection. When investigators exposed mice deficient for mitochondrial siderophore to systemic infection by E. coli, the animals resisted infection. The reason? E. coli bacteria had less iron to access from mitochondrial siderophore-deficient mice.

Additionally, mammals are not entirely defenseless from a bacteria raid on mitochondrial siderophore iron supplies. In another phase of their investigation, scientists found that normal mice secrete the protein lipocalin 24p3, which isolates bacterial siderophore and suppresses synthesis of mammalian siderophore.

"The action of lipocalin significantly reduced the mortality of the mice from the E. coli infection, and some mice actually recovered," Devireddy said. "That kind of delay in bacterial proliferation gave the immune system time to identify and then neutralize the microbe."

These findings highlight the potential of developing effective therapeutics to reverse bacterial infection.

"Any approach that would suppress either bacterial or mitochondrial siderophore and activate lipocalin-2 would likely slow infection, allowing the host's immune system to respond," Devireddy said. "Such novel approaches would also provide a much-needed alternative to treat those infections that have become antibiotics resistant."


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Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University
Source:Eurekalert

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