Navigation Links
Bacteria discovery could lead to antibiotics alternatives
Date:5/3/2012

Scientists have discovered an Achilles heel within our cells that bacteria are able to exploit to cause and spread infection.

The researchers say their findings could lead to the development of new anti-infective drugs as alternatives to antibiotics whose overuse has led to resistance.

University of Manchester researchers studied Listeria a potentially deadly group of bacteria that can cause listeriosis in humans when digested and found they are able to spread infection by hitching a ride on a naturally occurring protein called calpain.

"Bacteria produce a number of chemicals that allow them to invade a host and to establish an infection," said lead researcher Dr David Brough, who is based in Manchester's Faculty of Life Sciences.

"The chemicals produced depend upon many factors, such as the species of bacteria, the type of host, and also whether the infection grows inside or outside a cell.

"We have investigated the growth of Listeria, a pathogenic bacterium that grows inside cells. An essential step for its growth, and thus the infection, is the bacteria's ability to move from within one compartment in a cell to another.

"We discovered that in order for this particular type of bacteria to move and to grow some of the host cells biology is exploited, a protein called calpain. Without calpain the bacteria cannot move within the cell and so do not grow.

"This discovery highlights the possibility of using drugs against these host proteins to block infections, potentially reducing the need to use antibiotics."

The study, funded by the Wellcome Trust, is published in the PLoS ONE journal.


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1

Related biology news :

1. Disinfectants can make bacteria resistant to treatment
2. H. Pylori bacteria may help prevent some esophageal cancers
3. Scientists discover bacteria that can cause bone infections
4. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
5. Gene against bacterial attack unravelled
6. Predatory bacterial swarm uses rippling motion to reach prey
7. Bacteria manage perfume oil production from grass
8. Nature study demonstrates that bacterial clotting depends on clustering
9. Battling bacteria in the blood: Researchers tackle deadly infections
10. Shifts in soil bacterial populations linked to wetland restoration success
11. New bacteria discovered in raw milk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... 2016   Veridium , a leader in ... new CEO James Stickland . Stickland, a ... experience, has served in senior executive roles for ... in expanding a pipeline of venture capital and ... recently served as managing director of U.K.-based fintech ...
(Date:12/5/2016)... Dec. 5, 2016  The Office of Justice ... "Can CT Scans Enhance or Replace Medico Legal ... of supporting or replacing forensic autopsies with postmortem ... In response to recommendations made by ... using CT scans as a potential component of ...
(Date:11/30/2016)... 2016  higi SH llc (higi) announced today ... national brands, industry thought-leaders and celebrity influencers looking ... for taking steps to live healthier, more active ... higi has built the largest self-screening health station ... people who have conducted over 185 million biometric ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 8, 2016 Eurofins announces the appointment of Sean ... Eurofins Scientific Inc. (ESI). Mr. Murray will bring ... and entrepreneurial experience in leading international business teams. As the National ... market to uphold Eurofins, status as the global leader in bio-analytical ... , , ...
(Date:12/8/2016)... Dec. 8, 2016  Anaconda BioMed S.L., a pre-clinical ... the next generation neuro-thrombectomy system for the treatment of ... G. Jovin, MD to join its Scientific Advisory Board ... strategic network of scientific and clinical experts to Anaconda ... the ANCD BRAIN ® to its clinical phase. ...
(Date:12/8/2016)... 2016  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or ... developing and commercializing products to treat rare diseases ... today the long-term follow-up data from its Phase ... Innate Defense Regulator (IDR), in the treatment of ... patients undergoing chemoradiation therapy (CRT).  The additional 12-month ...
(Date:12/8/2016)... 2016  Partnering to fuel Philadelphia,s ... of Southeastern Pennsylvania (" Ben ... of Independence Blue Cross; and Safeguard Scientifics ("Safeguard") (NYSE: ... a $6 million funding initiative over a four year ... Responding to a burgeoning economic vitality in digital health, ...
Breaking Biology Technology: